Rab7b RAB7B, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab7bprovided by MGI
Official Full Name: RAB7B, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:2442295
See related: Ensembl:ENSMUSG00000052688 AllianceGenome:MGI:2442295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5430435G22Rik
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of toll-like receptor 4 signaling pathway and negative regulation of toll-like receptor 9 signaling pathway. Acts upstream of or within cellular response to type II interferon. Located in late endosome; lysosome; and phagocytic vesicle. Orthologous to human RAB7B (RAB7B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 5.7), mammary gland adult (RPKM 3.8) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.18 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131616412..131646288)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131688681..131715443)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes.
Title: Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in late endosome to Golgi transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ras-related protein Rab-7b

NP_001298025.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NP_663484.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_006529491.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_006529492.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_006529493.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_006529494.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_006529496.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_036019822.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_036019826.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_036019827.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311096.1 → NP_001298025.1 ras-related protein Rab-7b isoform 2

See identical proteins and their annotated locations for NP_001298025.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK030688, AK036056, AK163610

Consensus CDS

CCDS78677.1

UniProtKB/TrEMBL

J9UUF7

Related

ENSMUSP00000066452.4, ENSMUST00000064664.10

Conserved Domains (1) summary

cd00154
Location:9 → 132

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
NM_145509.3 → NP_663484.1 ras-related protein Rab-7b isoform 1

See identical proteins and their annotated locations for NP_663484.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC138277, AK030688, AK163610

Consensus CDS

CCDS15272.1

UniProtKB/Swiss-Prot

Q0PD09, Q8BJT0, Q8BZB1, Q8VEA8

Related

ENSMUSP00000065456.3, ENSMUST00000064679.9

Conserved Domains (1) summary

cd00154
Location:9 → 169

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

131616412..131646288

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163929.1 → XP_036019822.1 ras-related protein Rab-7b isoform X2

Conserved Domains (1) summary

cd00154
Location:67 → 227

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
XM_006529429.4 → XP_006529492.1 ras-related protein Rab-7b isoform X3

Conserved Domains (1) summary

cd00154
Location:67 → 190

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
XM_006529431.4 → XP_006529494.1 ras-related protein Rab-7b isoform X6

Conserved Domains (1) summary

cl38936
Location:67 → 155

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006529428.5 → XP_006529491.1 ras-related protein Rab-7b isoform X1

Conserved Domains (1) summary

cd00154
Location:67 → 227

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
XM_006529433.4 → XP_006529496.1 ras-related protein Rab-7b isoform X8

UniProtKB/TrEMBL

D3YZQ6

Conserved Domains (1) summary

cl38936
Location:9 → 97

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036163933.1 → XP_036019826.1 ras-related protein Rab-7b isoform X4

Conserved Domains (1) summary

cd00154
Location:21 → 181

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
XM_036163934.1 → XP_036019827.1 ras-related protein Rab-7b isoform X7

UniProtKB/TrEMBL

J9UUF7

Conserved Domains (1) summary

cd00154
Location:9 → 132

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
XM_006529430.3 → XP_006529493.1 ras-related protein Rab-7b isoform X5

See identical proteins and their annotated locations for XP_006529493.1

UniProtKB/Swiss-Prot

Q0PD09, Q8BJT0, Q8BZB1, Q8VEA8

Conserved Domains (1) summary

cd00154
Location:9 → 169

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)