U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Klhl20 kelch-like 20 [ Mus musculus (house mouse) ]

Gene ID: 226541, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Klhl20provided by MGI
Official Full Name
kelch-like 20provided by MGI
Primary source
MGI:MGI:2444855
See related
Ensembl:ENSMUSG00000026705 AllianceGenome:MGI:2444855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kleip; mKIAA4210; D930050H05Rik
Summary
Predicted to enable type II interferon binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Golgi to endosome transport; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K33-linked ubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in PML body and trans-Golgi network. Is expressed in cranial ganglion; dorsal root ganglion; hindbrain; and thymus primordium. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 5.6), limb E14.5 (RPKM 5.3) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Klhl20 in Genome Data Viewer
Location:
1 H2.1; 1 69.75 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160915945..160959078, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161088375..161131508, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene aspartyl-tRNA synthetase 2 (mitochondrial) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163000837-163001115 Neighboring gene STARR-positive B cell enhancer ABC_E11097 Neighboring gene centromere protein L Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163061431-163061751 Neighboring gene STARR-seq mESC enhancer starr_02813 Neighboring gene STARR-seq mESC enhancer starr_02814 Neighboring gene STARR-seq mESC enhancer starr_02815 Neighboring gene ankyrin repeat domain 45 Neighboring gene STARR-seq mESC enhancer starr_02817 Neighboring gene testis expressed 50 Neighboring gene predicted gene, 51252

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Angiopoietin-1 is regulated by miR-204 and contributes to corneal neovascularization in KLEIP-deficient mice. Kather JN, et al. Invest Ophthalmol Vis Sci, 2014 Jun 10. PMID 24917145
  2. Kelch-like ECT2-interacting protein KLEIP regulates late-stage pulmonary maturation via Hif-2α in mice. Woik N, et al. Dis Model Mech, 2014 Jun. PMID 24785085, Free PMC Article
  3. KLEIP deficiency in mice causes progressive corneal neovascular dystrophy. Hahn N, et al. Invest Ophthalmol Vis Sci, 2012 May 31. PMID 22511632
  4. Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. Liu CC, et al. Mol Cell, 2016 Jan 7. PMID 26687681
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Transgenic (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA4210, MGC28950

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables type II interferon binding ISO
Inferred from Sequence Orthology
more info
  
enables type II interferon binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi to endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K33-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K33-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kelch-like protein 20
Names
Kelch-like ECT2 interacting protein
kelch-like ECT2-interacting protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039482.1 → NP_001034571.1  kelch-like protein 20

    See identical proteins and their annotated locations for NP_001034571.1

    Status: VALIDATED

    Source sequence(s)
    AC138640, AK050964, AK220547, BY020135
    Consensus CDS
    CCDS35748.1
    UniProtKB/Swiss-Prot
    Q5DTH3, Q8BWA2, Q8VCK5
    Related
    ENSMUSP00000107238.2, ENSMUST00000111611.8
    Conserved Domains (3) summary
    PHA03098
    Location:58 → 581
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:350 → 394
    Kelch; KELCH repeat [structural motif]
    cd18249
    Location:40 → 167
    BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    160915945..160959078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164066.1 → XP_036019959.1  kelch-like protein 20 isoform X1

    Conserved Domains (2) summary
    PHA03098
    Location:27 → 284
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:53 → 97
    Kelch; KELCH repeat [structural motif]

RNA

  1. XR_373601.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144876.2: Suppressed sequence

    Description
    NM_144876.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCK5.2 GenPept UniProtKB/Swiss-Prot:Q8VCK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous