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Suco SUN domain containing ossification factor [ Mus musculus (house mouse) ]

Gene ID: 226551, updated on 2-Nov-2024

Summary

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Official Symbol
Sucoprovided by MGI
Official Full Name
SUN domain containing ossification factorprovided by MGI
Primary source
MGI:MGI:2138346
See related
Ensembl:ENSMUSG00000040297 AllianceGenome:MGI:2138346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Opt; 4732491B11
Summary
Involved in positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; and regulation of bone remodeling. Located in membrane and rough endoplasmic reticulum. Used to study osteogenesis imperfecta type 5. Orthologous to human SUCO (SUN domain containing ossification factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 8.6), bladder adult (RPKM 7.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Suco in Genome Data Viewer
Location:
1 H2.1; 1 69.95 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161643681..161704506, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161816112..161876837, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7765 Neighboring gene STARR-seq mESC enhancer starr_02829 Neighboring gene predicted gene, 31869 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163734643-163734826 Neighboring gene Fas ligand Neighboring gene cyclin-dependent kinase 7 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10050 Neighboring gene STARR-positive B cell enhancer ABC_E2578 Neighboring gene STARR-positive B cell enhancer ABC_E7766 Neighboring gene STARR-seq mESC enhancer starr_02830 Neighboring gene predicted gene, 31925 Neighboring gene RIKEN cDNA 4930558K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4367 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exome sequencing identifies SUCO mutations in mesial temporal lobe epilepsy. Sha Z, et al. Neurosci Lett, 2015 Mar 30. PMID 25668491
  2. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. Sohaskey ML, et al. J Cell Biol, 2010 May 3. PMID 20440000, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. neurons have abnormal development due to lack of SUCO, which may be a generalized-onset epilepsy-related gene
    Title: Exome sequencing identifies SUCO mutations in mesial temporal lobe epilepsy.
  2. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice.
    Title: Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC170004

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of bone remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUN domain-containing ossification factor
Names
SUN-like protein 1
membrane protein CH1
osteopotentia
protein C1orf9 homolog
protein osteopotentia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357401.1 → NP_001344330.1  SUN domain-containing ossification factor isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164414
    Conserved Domains (2) summary
    pfam03938
    Location:936 → 1010
    OmpH; Outer membrane protein (OmpH-like)
    pfam07738
    Location:326 → 455
    Sad1_UNC; Sad1 / UNC-like C-terminal

  2. NM_001357402.1 → NP_001344331.1  SUN domain-containing ossification factor isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164414
    UniProtKB/Swiss-Prot
    Q3TAG8, Q3V3T1, Q8C341, Q8CE34
    Conserved Domains (2) summary
    pfam03938
    Location:932 → 1006
    OmpH; Outer membrane protein (OmpH-like)
    pfam07738
    Location:322 → 451
    Sad1_UNC; Sad1 / UNC-like C-terminal

  3. NM_172645.3 → NP_766233.2  SUN domain-containing ossification factor isoform 1 precursor

    See identical proteins and their annotated locations for NP_766233.2

    Status: VALIDATED

    Source sequence(s)
    AC164414
    Consensus CDS
    CCDS48415.1
    UniProtKB/TrEMBL
    B2RRF3
    Related
    ENSMUSP00000044815.6, ENSMUST00000048377.11
    Conserved Domains (2) summary
    pfam04899
    Location:936 → 1005
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:326 → 455
    Sad1_UNC; Sad1 / UNC-like C-terminal

RNA

  1. NR_151683.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164414

  2. NR_151684.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164414

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    161643681..161704506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496761.4 → XP_006496824.1  SUN domain-containing ossification factor isoform X1

    Conserved Domains (2) summary
    pfam04899
    Location:932 → 1001
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:322 → 451
    Sad1_UNC; Sad1 / UNC-like C-terminal

  2. XM_017320016.3 → XP_017175505.1  SUN domain-containing ossification factor isoform X4

    Conserved Domains (2) summary
    pfam04899
    Location:936 → 1005
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:326 → 455
    Sad1_UNC; Sad1 / UNC-like C-terminal

  3. XM_006496763.4 → XP_006496826.1  SUN domain-containing ossification factor isoform X3

    Conserved Domains (2) summary
    pfam04899
    Location:925 → 994
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:322 → 444
    Sad1_UNC; Sad1 / UNC-like C-terminal

  4. XM_006496762.4 → XP_006496825.1  SUN domain-containing ossification factor isoform X2

    Conserved Domains (2) summary
    pfam04899
    Location:929 → 998
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:326 → 448
    Sad1_UNC; Sad1 / UNC-like C-terminal

  5. XM_006496765.4 → XP_006496828.1  SUN domain-containing ossification factor isoform X5

    Conserved Domains (2) summary
    pfam04899
    Location:936 → 1005
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:326 → 455
    Sad1_UNC; Sad1 / UNC-like C-terminal

RNA

  1. XR_003954894.2 RNA Sequence

  2. XR_003954895.2 RNA Sequence

  3. XR_004941879.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C341.3 GenPept UniProtKB/Swiss-Prot:Q8C341

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