U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rcsd1 RCSD domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 226594, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Rcsd1provided by MGI
Official Full Name
RCSD domain containing 1provided by MGI
Primary source
MGI:MGI:2676394
See related
Ensembl:ENSMUSG00000040723 AllianceGenome:MGI:2676394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CapZIP; Gm19627; A430105K13Rik
Summary
Predicted to enable actin filament binding activity; phosphatidylinositol phosphate binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including cellular hyperosmotic response; protein localization to endosome; and retrograde transport, endosome to Golgi. Predicted to be part of WASH complex. Predicted to be active in early endosome. Is expressed in several structures, including blood; chondrocranium; gut; meninges; and metanephros. Orthologous to human RCSD1 (RCSD domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 43.0), spleen adult (RPKM 17.7) and 15 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rcsd1 in Genome Data Viewer
Location:
1 H2.3; 1 72.99 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165476503..165537632, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165648945..165710063, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1570 Neighboring gene nuclear encoded tRNA proline 2 (anticodon CGG) Neighboring gene translin-associated factor X pseudogene Neighboring gene STARR-seq mESC enhancer starr_02911 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167591001-167591302 Neighboring gene STARR-positive B cell enhancer ABC_E1571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167636283-167636436 Neighboring gene STARR-positive B cell enhancer ABC_E11104 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167648574-167648683 Neighboring gene predicted gene, 51752 Neighboring gene STARR-positive B cell enhancer ABC_E1572 Neighboring gene STARR-positive B cell enhancer ABC_E4374 Neighboring gene cellular repressor of E1A-stimulated genes 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. Hempel A, et al. Dev Biol, 2017 Apr 1. PMID 28237811
  2. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Terami H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286962
  3. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Eyers CE, et al. Biochem J, 2005 Jul 1. PMID 15850461, Free PMC Article
  4. Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. Weiss AC, et al. Development, 2023 Mar 15. PMID 36960826
  5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC32399

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables retromer complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular hyperosmotic response IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
capZ-interacting protein
Names
protein kinase substrate CapZIP

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038846.1 → NP_001033935.1  capZ-interacting protein isoform b

    See identical proteins and their annotated locations for NP_001033935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C- termini compared to isoform a.
    Source sequence(s)
    AK168816, AK171323, BY230131
    Consensus CDS
    CCDS48425.1
    UniProtKB/Swiss-Prot
    Q3UZA1
    Related
    ENSMUSP00000095082.4, ENSMUST00000097474.9
    Conserved Domains (2) summary
    pfam05177
    Location:201 → 285
    RCSD; RCSD region
    pfam15255
    Location:51 → 136
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  2. NM_178593.3 → NP_848708.2  capZ-interacting protein isoform a

    See identical proteins and their annotated locations for NP_848708.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
    Source sequence(s)
    AK133961, AK168816, BY230131
    Consensus CDS
    CCDS48426.1
    UniProtKB/Swiss-Prot
    Q3TAD8, Q3TBC2, Q3TGA5, Q3UZA1, Q8R3A0
    Related
    ENSMUSP00000043724.9, ENSMUST00000040357.11
    Conserved Domains (3) summary
    COG5271
    Location:200 → 376
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:231 → 315
    RCSD; RCSD region
    pfam15255
    Location:90 → 171
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165476503..165537632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496784.2 → XP_006496847.1  capZ-interacting protein isoform X4

    Conserved Domains (3) summary
    COG5271
    Location:185 → 361
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:216 → 300
    RCSD; RCSD region
    pfam15255
    Location:66 → 151
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  2. XM_006496781.2 → XP_006496844.1  capZ-interacting protein isoform X1

    Conserved Domains (3) summary
    COG5271
    Location:215 → 391
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:246 → 330
    RCSD; RCSD region
    pfam15255
    Location:96 → 181
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  3. XM_006496783.3 → XP_006496846.1  capZ-interacting protein isoform X3

    See identical proteins and their annotated locations for XP_006496846.1

    UniProtKB/Swiss-Prot
    Q3TAD8, Q3TBC2, Q3TGA5, Q3UZA1, Q8R3A0
    Conserved Domains (3) summary
    COG5271
    Location:200 → 376
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:231 → 315
    RCSD; RCSD region
    pfam15255
    Location:90 → 171
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  4. XM_011238794.2 → XP_011237096.1  capZ-interacting protein isoform X2

    See identical proteins and their annotated locations for XP_011237096.1

    Conserved Domains (3) summary
    COG5271
    Location:211 → 387
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:242 → 326
    RCSD; RCSD region
    pfam15255
    Location:92 → 177
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UZA1.1 GenPept UniProtKB/Swiss-Prot:Q3UZA1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools