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Wdr26 WD repeat domain 26 [ Mus musculus (house mouse) ]

Gene ID: 226757, updated on 2-Nov-2024

Summary

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Official Symbol
Wdr26provided by MGI
Official Full Name
WD repeat domain 26provided by MGI
Primary source
MGI:MGI:1923825
See related
Ensembl:ENSMUSG00000038733 AllianceGenome:MGI:1923825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gid7; 1600024A01Rik
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of GID complex. Orthologous to human WDR26 (WD repeat domain 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 34.5), liver E14.5 (RPKM 31.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wdr26 in Genome Data Viewer
Location:
1 H4; 1 84.53 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (181000791..181046211, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181173226..181220921, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 3, pseudogene Neighboring gene nuclear VCP-like Neighboring gene STARR-positive B cell enhancer ABC_E2593 Neighboring gene STARR-positive B cell enhancer ABC_E2026 Neighboring gene cornichon family AMPA receptor auxiliary protein 4 Neighboring gene predicted gene, 50602 Neighboring gene predicted gene, 38664 Neighboring gene STARR-positive B cell enhancer ABC_E5875 Neighboring gene ribosomal protein L35A, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E4401 Neighboring gene STARR-seq mESC enhancer starr_03234 Neighboring gene STARR-seq mESC enhancer starr_03237 Neighboring gene HAUS augmin-like complex, subunit 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WDR26 and MTF2 are therapeutic targets in multiple myeloma. Sun F, et al. J Hematol Oncol, 2021 Dec 7. PMID 34876184, Free PMC Article
  2. The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration. Sun Z, et al. J Biol Chem, 2011 Dec 23. PMID 22065575, Free PMC Article
  3. The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. Dell EJ, et al. J Biol Chem, 2002 Dec 20. PMID 12359736
  4. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
  5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR26 and MTF2 are therapeutic targets in multiple myeloma.
    Title: WDR26 and MTF2 are therapeutic targets in multiple myeloma.
  2. WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
    Title: The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403581.1 → NP_001390510.1  WD repeat-containing protein 26 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113084

  2. NM_001403582.1 → NP_001390511.1  WD repeat-containing protein 26 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113084

  3. NM_001403583.1 → NP_001390512.1  WD repeat-containing protein 26 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113084
    UniProtKB/TrEMBL
    E0CYH4
    Related
    ENSMUSP00000124186.2, ENSMUST00000162963.8

  4. NM_001403584.1 → NP_001390513.1  WD repeat-containing protein 26 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113084

  5. NM_001403585.1 → NP_001390514.1  WD repeat-containing protein 26 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113084

  6. NM_001403586.1 → NP_001390515.1  WD repeat-containing protein 26 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC113084

  7. NM_001403587.1 → NP_001390516.1  WD repeat-containing protein 26 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC113084

  8. NM_001403588.1 → NP_001390517.1  WD repeat-containing protein 26 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC113084

  9. NM_001403589.1 → NP_001390518.1  WD repeat-containing protein 26 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC113084

  10. NM_145514.6 → NP_663489.4  WD repeat-containing protein 26 isoform 1

    See identical proteins and their annotated locations for NP_663489.4

    Status: VALIDATED

    Source sequence(s)
    AC113084
    Consensus CDS
    CCDS15583.2
    UniProtKB/Swiss-Prot
    E9PX83, Q3TK81, Q8C4F3, Q8C6G8, Q8VDZ6
    UniProtKB/TrEMBL
    A0A494BB75
    Related
    ENSMUSP00000124592.2, ENSMUST00000162819.9
    Conserved Domains (4) summary
    smart00668
    Location:136 → 211
    CTLH; C-terminal to LisH motif
    COG2319
    Location:326 → 621
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:329 → 621
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:339 → 379
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_175389.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113084

  2. NR_175390.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113084

  3. NR_175391.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113084

  4. NR_175392.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113084

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    181000791..181046211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496816.5 → XP_006496879.1  WD repeat-containing protein 26 isoform X1

    UniProtKB/TrEMBL
    A0A494BB75
    Conserved Domains (4) summary
    smart00668
    Location:136 → 211
    CTLH; C-terminal to LisH motif
    cd00200
    Location:329 → 621
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:339 → 379
    7WD40; WD40 repeat [structural motif]
    pfam17814
    Location:106 → 133
    LisH_TPL; LisH-like dimerisation domain

RNA

  1. XR_004941928.1 RNA Sequence

  2. XR_373606.5 RNA Sequence

  3. XR_003954940.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C6G8.3 GenPept UniProtKB/Swiss-Prot:Q8C6G8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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