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Zfp2 zinc finger protein 2 [ Mus musculus (house mouse) ]

Gene ID: 22678, updated on 14-Nov-2024

Summary

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Official Symbol
Zfp2provided by MGI
Official Full Name
zinc finger protein 2provided by MGI
Primary source
MGI:MGI:99167
See related
Ensembl:ENSMUSG00000049321 AllianceGenome:MGI:99167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKR2; Fnp-2; Zfp-2; mkr-2; mszf87; 9930007F06Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in nucleus. Is expressed in several structures, including nervous system; urinary system; and vertebral pre-cartilage condensation. Orthologous to human ZFP2 (ZFP2 zinc finger protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 2.3), whole brain E14.5 (RPKM 2.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp2 in Genome Data Viewer
Location:
11 B1.3; 11 30.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50788092..50807043, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50897265..50916216, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6979 Neighboring gene glutamate receptor, metabotropic 6 Neighboring gene zinc finger protein 454 Neighboring gene STARR-seq mESC enhancer starr_29409 Neighboring gene zinc finger protein 354B Neighboring gene RIKEN cDNA 4933414I15 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons. Chowdhury K, et al. EMBO J, 1988 May. PMID 3409867, Free PMC Article
  2. A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Chowdhury K, et al. Cell, 1987 Mar 13. PMID 3815523
  3. Zinc finger protein gene complexes on mouse chromosomes 8 and 11. Nadeau JH, et al. Genomics, 1990 Nov. PMID 1981050
  4. ILDR2 stabilization is regulated by its interaction with GRP78. Watanabe K, et al. Sci Rep, 2021 Apr 16. PMID 33863978, Free PMC Article
  5. Zinc finger protein genes in the mouse genome. Ashworth A, et al. Mamm Genome, 1991. PMID 1797234

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107189

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein ZFP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044697.2 → NP_001038162.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_001038162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    AK141471, BC052029, BY107004
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Related
    ENSMUSP00000112079.2, ENSMUST00000116378.8
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001044698.2 → NP_001038163.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_001038163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    AK141471, BC052029, BY107004
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001044700.2 → NP_001038165.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_001038165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    BC052029, BC089506, BY107004
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001294323.1 → NP_001281252.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_001281252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    AL627215, BC052029, BY107004, CJ044064
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Related
    ENSMUSP00000104757.2, ENSMUST00000109129.8
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_178447.3 → NP_848542.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_848542.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    AL627215, BC052029, BY107004
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Related
    ENSMUSP00000104756.2, ENSMUST00000109128.8
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50788092..50807043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314506.2 → XP_017169995.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030245935.2 → XP_030101795.1  zinc finger protein ZFP2 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:131 → 484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:417 → 437
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030245940.1 → XP_030101800.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036156640.1 → XP_036012533.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036156638.1 → XP_036012531.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036156639.1 → XP_036012532.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_030245936.1 → XP_030101796.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_036156637.1 → XP_036012530.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_030245938.1 → XP_030101798.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. XM_030245941.1 → XP_030101801.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. XM_030245937.2 → XP_030101797.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. XM_030245939.2 → XP_030101799.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001044699.1: Suppressed sequence

    Description
    NM_001044699.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  2. NM_009550.1: Suppressed sequence

    Description
    NM_009550.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08043.2 GenPept UniProtKB/Swiss-Prot:P08043

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