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Zfp207 zinc finger protein 207 [ Mus musculus (house mouse) ]

Gene ID: 22680, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp207provided by MGI
Official Full Name
zinc finger protein 207provided by MGI
Primary source
MGI:MGI:1340045
See related
Ensembl:ENSMUSG00000017421 AllianceGenome:MGI:1340045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zep; BuGZ; Znf207; 8430401D15Rik
Summary
Enables heparin binding activity and microtubule binding activity. Involved in mitotic spindle assembly. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and retina. Orthologous to human ZNF207 (zinc finger protein 207). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 25.2), limb E14.5 (RPKM 24.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp207 in Genome Data Viewer
Location:
11 B5; 11 47.83 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80274105..80299387)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80383279..80408561)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:80116169-80116470 Neighboring gene rhomboid like 3 Neighboring gene RIKEN cDNA 5730455P16 gene Neighboring gene STARR-positive B cell enhancer ABC_E7026 Neighboring gene STARR-seq mESC enhancer starr_30146 Neighboring gene STARR-seq mESC enhancer starr_30149 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Neighboring gene cyclin dependent kinase 5, regulatory subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. Malla S, et al. EMBO Rep, 2022 Feb 3. PMID 35037361, Free PMC Article
  2. Zep: A novel zinc finger protein containing a large proline-rich domain. Taguchi E, et al. J Biochem, 1998 Dec 1. PMID 9832628
  3. Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes. Dai XX, et al. Oncotarget, 2016 May 24. PMID 27177335, Free PMC Article
  4. Phase transition of spindle-associated protein regulate spindle apparatus assembly. Jiang H, et al. Cell, 2015 Sep 24. PMID 26388440, Free PMC Article
  5. BCAS2 is involved in alternative splicing and mouse oocyte development. Zhang J, et al. FASEB J, 2022 Feb. PMID 34972250

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle matrix ISO
Inferred from Sequence Orthology
more info
  
located_in spindle matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
BUB3-interacting and GLEBS motif-containing protein ZNF207
Names
49 kDa zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130169.1 → NP_001123641.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 1

    See identical proteins and their annotated locations for NP_001123641.1

    Status: VALIDATED

    Source sequence(s)
    AK146787, BB666896, DV661373
    Consensus CDS
    CCDS48863.1
    UniProtKB/Swiss-Prot
    E9PW12, Q99LA2, Q9JMD0, Q9Z326
    Related
    ENSMUSP00000054168.9, ENSMUST00000053740.15
    Conserved Domains (2) summary
    sd00020
    Location:13 → 34
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:437 → 472
    SMN; Survival motor neuron protein (SMN)

  2. NM_001130170.1 → NP_001123642.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB013357, AK140139, BB666896, DV661373
    Consensus CDS
    CCDS48865.1
    UniProtKB/Swiss-Prot
    Q9JMD0
    Related
    ENSMUSP00000132968.2, ENSMUST00000165565.8
    Conserved Domains (2) summary
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:382 → 456
    SMN; Survival motor neuron protein (SMN)

  3. NM_001130171.1 → NP_001123643.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 3

    See identical proteins and their annotated locations for NP_001123643.1

    Status: VALIDATED

    Source sequence(s)
    AK146787, AK159683, BB666896, DV661373
    Consensus CDS
    CCDS48864.1
    UniProtKB/Swiss-Prot
    Q9JMD0
    Related
    ENSMUSP00000017567.7, ENSMUST00000017567.14
    Conserved Domains (3) summary
    sd00020
    Location:13 → 34
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:406 → 441
    SMN; Survival motor neuron protein (SMN)
    cd20908
    Location:10 → 90
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  4. NM_001362721.1 → NP_001349650.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL591146, DV661373
    Conserved Domains (2) summary
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:390 → 425
    SMN; Survival motor neuron protein (SMN)

  5. NM_011751.3 → NP_035881.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 4

    See identical proteins and their annotated locations for NP_035881.1

    Status: VALIDATED

    Source sequence(s)
    AB013357, BB666896, DV661373
    UniProtKB/Swiss-Prot
    Q9JMD0
    Conserved Domains (2) summary
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:363 → 437
    SMN; Survival motor neuron protein (SMN)

RNA

  1. NR_045038.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK087885, BF464890

  2. NR_156116.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591146, BF464890

  3. NR_156117.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591146, BF464890

  4. NR_156118.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591146, BF464890

  5. NR_156119.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591146, BF464890

  6. NR_156120.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591146, BF464890

  7. NR_156121.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591146, BF464890

  8. NR_156122.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591146, BF464890

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80274105..80299387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533189.4 → XP_006533252.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X1

    See identical proteins and their annotated locations for XP_006533252.1

    UniProtKB/Swiss-Prot
    E9PW12, Q99LA2, Q9JMD0, Q9Z326
    Conserved Domains (2) summary
    sd00020
    Location:13 → 34
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:437 → 472
    SMN; Survival motor neuron protein (SMN)

  2. XM_036156641.1 → XP_036012534.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X2

    Related
    ENSMUSP00000136727.2, ENSMUST00000178665.8
    Conserved Domains (3) summary
    sd00020
    Location:13 → 34
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:406 → 441
    SMN; Survival motor neuron protein (SMN)
    cd20908
    Location:10 → 90
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RNA

  1. XR_001779976.2 RNA Sequence

  2. XR_001779977.3 RNA Sequence

  3. XR_004936936.1 RNA Sequence

  4. XR_001779978.3 RNA Sequence

  5. XR_004936938.1 RNA Sequence

  6. XR_001779985.3 RNA Sequence

  7. XR_388441.5 RNA Sequence

  8. XR_001779983.3 RNA Sequence

  9. XR_003949420.2 RNA Sequence

  10. XR_003949424.2 RNA Sequence

  11. XR_003949422.2 RNA Sequence

  12. XR_001779990.3 RNA Sequence

  13. XR_003949421.2 RNA Sequence

  14. XR_001779989.3 RNA Sequence

  15. XR_004936937.1 RNA Sequence

  16. XR_004936939.1 RNA Sequence

  17. XR_003949418.2 RNA Sequence

  18. XR_003949419.2 RNA Sequence

  19. XR_388432.3 RNA Sequence

  20. XR_004936935.1 RNA Sequence

  21. XR_003949425.2 RNA Sequence

  22. XR_001779986.3 RNA Sequence

  23. XR_001779988.3 RNA Sequence

  24. XR_001779982.3 RNA Sequence

  25. XR_003949417.2 RNA Sequence

  26. XR_001779991.3 RNA Sequence

  27. XR_004936944.1 RNA Sequence

  28. XR_003949430.1 RNA Sequence

  29. XR_001779996.2 RNA Sequence

  30. XR_003949428.1 RNA Sequence

  31. XR_004936941.1 RNA Sequence

  32. XR_004936942.1 RNA Sequence

  33. XR_004936943.1 RNA Sequence

  34. XR_004936940.1 RNA Sequence

  35. XR_003949416.1 RNA Sequence

  36. XR_003949427.1 RNA Sequence

  37. XR_003949426.1 RNA Sequence

  38. XR_004936945.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMD0.1 GenPept UniProtKB/Swiss-Prot:Q9JMD0

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