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Eif5b eukaryotic translation initiation factor 5B [ Mus musculus (house mouse) ]

Gene ID: 226982, updated on 28-Oct-2024

Summary

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Official Symbol
Eif5bprovided by MGI
Official Full Name
eukaryotic translation initiation factor 5Bprovided by MGI
Primary source
MGI:MGI:2441772
See related
Ensembl:ENSMUSG00000026083 AllianceGenome:MGI:2441772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IF2; A030003E17Rik
Summary
Predicted to enable GTP binding activity; GTPase activity; and nucleic acid binding activity. Predicted to be involved in regulation of translational initiation; ribosome assembly; and translational initiation. Is active in synapse. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E11.5 (RPKM 15.1), liver E14 (RPKM 11.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Eif5b in Genome Data Viewer
Location:
1 B; 1 16.4 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38037091..38094660)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37998010..38055579)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00687 Neighboring gene STARR-positive B cell enhancer ABC_E3269 Neighboring gene STARR-positive B cell enhancer ABC_E10006 Neighboring gene lysozyme G-like 1 Neighboring gene STARR-seq mESC enhancer starr_00688 Neighboring gene thioredoxin domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_00689 Neighboring gene predicted gene, 34448 Neighboring gene STARR-seq mESC enhancer starr_00690 Neighboring gene STARR-seq mESC enhancer starr_00691 Neighboring gene REV1, DNA directed polymerase Neighboring gene predicted gene 5099 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene predicted gene 16150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. Lee S, et al. Proc Natl Acad Sci U S A, 2014 Oct 14. PMID 25261552, Free PMC Article
  2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. Bohnsack MT, et al. EMBO J, 2002 Nov 15. PMID 12426392, Free PMC Article
  3. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. Li R, et al. PLoS Genet, 2016 Jun. PMID 27352031, Free PMC Article
  4. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
  5. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. eIF5B overexpression promotes maturation of G0-like immature oocytes and causes cell death, an alternative to G0, in serum-starved THP1 cells.
    Title: Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages.
  2. eIF5B, the homologue of bacterial IF2, is a GTPase implicated in joining the ribosomal subunits.
    Title: Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 5B
Names
eIF-5B
translation initiation factor IF-2
NP_938045.2
XP_036020208.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198303.2 → NP_938045.2  eukaryotic translation initiation factor 5B

    See identical proteins and their annotated locations for NP_938045.2

    Status: VALIDATED

    Source sequence(s)
    AK145732, AK173016, BC103806, CN670500, CN724918
    Consensus CDS
    CCDS35544.1
    UniProtKB/Swiss-Prot
    Q05D44, Q3SYI4, Q3TQJ8, Q3UL37, Q3UM39, Q6PAI0, Q8CFF4, Q8CGD6
    Related
    ENSMUSP00000027252.8, ENSMUST00000027252.8
    Conserved Domains (5) summary
    cd01887
    Location:628 → 841
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    PRK04004
    Location:623 → 1198
    PRK04004; translation initiation factor IF-2; Validated
    pfam11987
    Location:962 → 1063
    IF-2; Translation-initiation factor 2
    cd03703
    Location:851 → 961
    aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
    cd16266
    Location:1088 → 1182
    IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    38037091..38094660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164315.1 → XP_036020208.1  eukaryotic translation initiation factor 5B isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05D44.2 GenPept UniProtKB/Swiss-Prot:Q05D44

Gene LinkOut

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Chemical Information
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