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Zfp52 zinc finger protein 52 [ Mus musculus (house mouse) ]

Gene ID: 22710, updated on 28-Oct-2024

Summary

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Official Symbol
Zfp52provided by MGI
Official Full Name
zinc finger protein 52provided by MGI
Primary source
MGI:MGI:99199
See related
Ensembl:ENSMUSG00000051341 AllianceGenome:MGI:99199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp76; KRAB11; Zfp-52; mszf24; mszf34; mszf75; zfec29; mszf23-2
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and liver. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 1.0), CNS E18 (RPKM 0.8) and 26 other tissues See more
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Genomic context

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See Zfp52 in Genome Data Viewer
Location:
17 A3.2; 17 11.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21755801..21783624)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21533725..21563362)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42008 Neighboring gene STARR-seq mESC enhancer starr_42009 Neighboring gene predicted gene, 52290 Neighboring gene STARR-positive B cell enhancer ABC_E3186 Neighboring gene zinc finger protein 53 Neighboring gene RIKEN cDNA 9330136K24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:21669090-21669243 Neighboring gene STARR-positive B cell enhancer ABC_E9942 Neighboring gene zinc finger protein 948 Neighboring gene predicted gene, 30531 Neighboring gene predicted gene, 41541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A cluster of related zinc finger protein genes is deleted in the mouse embryonic lethal mutation tw18. Crossley PH, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1680234, Free PMC Article
  2. Physical analysis of the region deleted in the tw18 allele of the mouse tcl-4 complementation group. Barclay J, et al. Genomics, 1996 Aug 15. PMID 8812414
  3. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  4. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  5. Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Okada A, et al. Birth Defects Res A Clin Mol Teratol, 2005 Apr. PMID 15799026

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 52
Names
KRAB-zinc finger protein 76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144515.2 → NP_653098.2  zinc finger protein 52

    See identical proteins and their annotated locations for NP_653098.2

    Status: VALIDATED

    Source sequence(s)
    AK032299, BY206348
    Consensus CDS
    CCDS37464.1
    UniProtKB/TrEMBL
    Q8BJ45
    Related
    ENSMUSP00000156662.2, ENSMUST00000233281.2
    Conserved Domains (5) summary
    COG5048
    Location:184 → 615
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440 → 460
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box
    pfam13465
    Location:648 → 673
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:690 → 714
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    21755801..21783624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160580.1 → XP_036016473.1  zinc finger protein 52 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:147 → 578
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:403 → 423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:611 → 636
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036160581.1 → XP_036016474.1  zinc finger protein 52 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:105 → 536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:361 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:569 → 594
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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