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Zfp60 zinc finger protein 60 [ Mus musculus (house mouse) ]

Gene ID: 22718, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp60provided by MGI
Official Full Name
zinc finger protein 60provided by MGI
Primary source
MGI:MGI:99207
See related
Ensembl:ENSMUSG00000037640 AllianceGenome:MGI:99207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mfg3; Mfg-3; 6330516O17Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human ZNF780A (zinc finger protein 780A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 13.6), CNS E14 (RPKM 12.9) and 19 other tissues See more
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Genomic context

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See Zfp60 in Genome Data Viewer
Location:
7 A3; 7 15.97 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27430834..27451114)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27731409..27751689)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18383 Neighboring gene zinc finger protein 607B Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28474189-28474376 Neighboring gene STARR-seq mESC enhancer starr_18384 Neighboring gene PHD finger protein 5B, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28516760-28516943 Neighboring gene STARR-seq mESC enhancer starr_18388 Neighboring gene STARR-seq mESC enhancer starr_18389 Neighboring gene predicted gene 10046 Neighboring gene predicted gene, 29810

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zfp60, a mouse zinc finger gene expressed transiently during in vitro muscle differentiation. Perez M, et al. FEBS Lett, 1996 Jun 3. PMID 8674531
  2. Mouse genes coding for "zinc-finger"-containing proteins: characterization and expression in differentiated cells. Passananti C, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2512579, Free PMC Article
  3. The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation. Ganss B, et al. J Bone Miner Res, 2002 Dec. PMID 12469909
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. role as negative regulator of cartilage differentiation
    Title: The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 60
Names
zfp-60
zinc finger protein Mfg-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009560.2 → NP_033586.2  zinc finger protein 60

    See identical proteins and their annotated locations for NP_033586.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AA718695, AC074312, CAAA01066021, CB526626
    Consensus CDS
    CCDS21030.1
    UniProtKB/TrEMBL
    Q8K0D9
    Related
    ENSMUSP00000036627.8, ENSMUST00000042641.14
    Conserved Domains (5) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:212 → 640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:511 → 531
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:636 → 658
    zf-H2C2_2; Zinc-finger double domain

  2. NM_029531.2 → NP_083807.2  zinc finger protein 60

    See identical proteins and their annotated locations for NP_083807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK149305, CAAA01066021
    Consensus CDS
    CCDS21030.1
    UniProtKB/TrEMBL
    Q8K0D9
    Related
    ENSMUSP00000103973.2, ENSMUST00000108336.8
    Conserved Domains (5) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:212 → 640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:511 → 531
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:636 → 658
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27430834..27451114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16374.2 GenPept UniProtKB/Swiss-Prot:P16374

Gene LinkOut

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