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Zfp92 zinc finger protein 92 [ Mus musculus (house mouse) ]

Gene ID: 22754, updated on 28-Oct-2024

Summary

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Official Symbol
Zfp92provided by MGI
Official Full Name
zinc finger protein 92provided by MGI
Primary source
MGI:MGI:108094
See related
Ensembl:ENSMUSG00000031374 AllianceGenome:MGI:108094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; skin; and thymus. Orthologous to human ZFP92 (ZFP92 zinc finger protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfp92 in Genome Data Viewer
Location:
X A7.3; X 37.31 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72454555..72473980)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73410949..73428382)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 275 Neighboring gene PNMA family member 6E Neighboring gene three prime repair exonuclease 2 Neighboring gene HAUS augmin-like complex, subunit 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes. Osipovich AB, et al. PLoS Genet, 2023 May. PMID 37155670, Free PMC Article
  2. A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28. Levin ML, et al. Genome Res, 1996 Jun. PMID 8828036
  3. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Davies W, et al. Nat Genet, 2005 Jun. PMID 15908950
  4. A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development. Osipovich AB, et al. Development, 2021 Mar 21. PMID 33653874, Free PMC Article
  5. Identification of a cluster of X-linked imprinted genes in mice. Raefski AS, et al. Nat Genet, 2005 Jun. PMID 15908953

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes.
    Title: ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 92
Names
zfp-92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310531.1 → NP_001297460.1  zinc finger protein 92 isoform 2

    See identical proteins and their annotated locations for NP_001297460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL732461, BC096436
    Consensus CDS
    CCDS81135.1
    UniProtKB/TrEMBL
    Q4VAD4
    Related
    ENSMUSP00000083661.3, ENSMUST00000086470.3
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:134 → 299
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_009566.5 → NP_033592.2  zinc finger protein 92 isoform 1

    See identical proteins and their annotated locations for NP_033592.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK141522, AL732461, AW494753
    Consensus CDS
    CCDS30200.1
    UniProtKB/Swiss-Prot
    Q62396, Q9JJR0
    Related
    ENSMUSP00000033740.6, ENSMUST00000033740.12
    Conserved Domains (4) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:134 → 299
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:324 → 348
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72454555..72473980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318463.3 → XP_017173952.1  zinc finger protein 92 isoform X2

    UniProtKB/TrEMBL
    Q4VAD4
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:134 → 299
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006527964.4 → XP_006528027.1  zinc finger protein 92 isoform X1

    See identical proteins and their annotated locations for XP_006528027.1

    UniProtKB/Swiss-Prot
    Q62396, Q9JJR0
    Conserved Domains (4) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:134 → 299
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:324 → 348
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_386920.3 RNA Sequence

  2. XR_004940335.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62396.2 GenPept UniProtKB/Swiss-Prot:Q62396

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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