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Qsox2 quiescin Q6 sulfhydryl oxidase 2 [ Mus musculus (house mouse) ]

Gene ID: 227638, updated on 2-Nov-2024

Summary

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Official Symbol
Qsox2provided by MGI
Official Full Name
quiescin Q6 sulfhydryl oxidase 2provided by MGI
Primary source
MGI:MGI:2387194
See related
Ensembl:ENSMUSG00000036327 AllianceGenome:MGI:2387194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Soxn; Qscn6l1
Summary
This gene encodes a member of the sulfhydryl oxidase protein family. Members of this family catalyze formation of disulfide bonds. A similar protein in humans may sensitize neuroblastoma cells to interferon gamma-induced cell death. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 20.9), ovary adult (RPKM 12.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Qsox2 in Genome Data Viewer
Location:
2 A3; 2 18.45 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26099136..26127411, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26209124..26237399, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35745 Neighboring gene STARR-seq mESC enhancer starr_03976 Neighboring gene LIM homeobox protein 3 Neighboring gene STARR-seq mESC enhancer starr_03977 Neighboring gene STARR-positive B cell enhancer ABC_E10086 Neighboring gene STARR-seq mESC enhancer starr_03978 Neighboring gene predicted gene, 52504 Neighboring gene coiled-coil domain containing 187 Neighboring gene predicted gene, 35807

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cre-LoxP and tamoxifen-induced deletion of ovarian quiescin sulfhydryl oxidase 2 showed disruption of ovulatory activity in mice. Chen SY, et al. J Ovarian Res, 2024 Mar 19. PMID 38504307, Free PMC Article
  2. Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/Quiescin6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. Wittke I, et al. Cancer Res, 2003 Nov 15. PMID 14633699
  3. Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with segment-specific sperm surface associations. Wang TE, et al. Biol Reprod, 2018 Nov 1. PMID 29800099
  4. Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis. Wang TE, et al. Reproduction, 2021 Apr 20. PMID 33784244
  5. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Thorpe C, et al. Arch Biochem Biophys, 2002 Sep 1. PMID 12176051

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31729

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin-dependent sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin-dependent sulfhydryl oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sulfhydryl oxidase 2
Names
quiescin Q6-like 1
NP_001289885.1
NP_705787.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302956.1 → NP_001289885.1  sulfhydryl oxidase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001289885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK140324, AL773595
    UniProtKB/Swiss-Prot
    A2ALE0, A2ALE1, Q3TMX7, Q3TZA5, Q8C9I4, Q8K0M2
    Conserved Domains (2) summary
    cd02992
    Location:55 → 168
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:425 → 522
    Evr1_Alr; Erv1 / Alr family

  2. NM_153559.3 → NP_705787.1  sulfhydryl oxidase 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_705787.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate terminal exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. It encodes isoform 2 which has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK157992, AL773595
    Consensus CDS
    CCDS15798.1
    UniProtKB/Swiss-Prot
    Q3TMX7
    Related
    ENSMUSP00000037128.9, ENSMUST00000036187.9
    Conserved Domains (2) summary
    cd02992
    Location:55 → 168
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:425 → 522
    Evr1_Alr; Erv1 / Alr family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26099136..26127411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TMX7.1 GenPept UniProtKB/Swiss-Prot:Q3TMX7

Gene LinkOut

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