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Gbgt1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 227671, updated on 2-Nov-2024

Summary

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Official Symbol
Gbgt1provided by MGI
Official Full Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1provided by MGI
Primary source
MGI:MGI:2449143
See related
Ensembl:ENSMUSG00000026829 AllianceGenome:MGI:2449143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fs; Fgs
Summary
Enables globoside alpha-N-acetylgalactosaminyltransferase activity. Predicted to be involved in globoside metabolic process and lipid glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and vesicle. Is expressed in intestine; male reproductive gland or organ; nervous system; and stomach. Orthologous to human GBGT1 (globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 2.4), large intestine adult (RPKM 2.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gbgt1 in Genome Data Viewer
Location:
2 A3; 2 19.38 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28369368..28396048)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28479354..28506030)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04020 Neighboring gene piercer of microtubule wall 1 Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene STARR-seq mESC enhancer starr_04022 Neighboring gene STARR-positive B cell enhancer ABC_E10087 Neighboring gene ral guanine nucleotide dissociation stimulator Neighboring gene VISTA enhancer mm337 Neighboring gene carboxyl ester lipase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Forssman synthetase expression results in diminished shiga toxin susceptibility: a role for glycolipids in determining host-microbe interactions. Elliott SP, et al. Infect Immun, 2003 Nov. PMID 14573676, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC123927

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables globoside alpha-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables globoside alpha-N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in globoside metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid glycosylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Names
forssman glycolipid synthase
forssman glycolipid synthetase
NP_001411715.1
NP_631936.2
XP_006497981.1
XP_006497985.1
XP_017172754.1
XP_017172756.1
XP_017172757.1
XP_017172758.1
XP_036016677.1
XP_036016680.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424786.1 → NP_001411715.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL772249

  2. NM_139197.3 → NP_631936.2  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_631936.2

    Status: VALIDATED

    Source sequence(s)
    AL772249
    Consensus CDS
    CCDS15839.1
    UniProtKB/Swiss-Prot
    Q3KPA1, Q8CJF3, Q8VI38
    Related
    ENSMUSP00000127071.2, ENSMUST00000163121.8
    Conserved Domains (1) summary
    pfam03414
    Location:60 → 346
    Glyco_transf_6; Glycosyltransferase family 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28369368..28396048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317269.3 → XP_017172758.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X3

    Conserved Domains (1) summary
    cl11394
    Location:34 → 316
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_017317265.3 → XP_017172754.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam03414
    Location:75 → 361
    Glyco_transf_6; Glycosyltransferase family 6

  3. XM_006497918.4 → XP_006497981.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_006497981.1

    UniProtKB/Swiss-Prot
    Q3KPA1, Q8CJF3, Q8VI38
    Conserved Domains (1) summary
    pfam03414
    Location:60 → 346
    Glyco_transf_6; Glycosyltransferase family 6

  4. XM_036160784.1 → XP_036016677.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam03414
    Location:75 → 361
    Glyco_transf_6; Glycosyltransferase family 6

  5. XM_017317267.3 → XP_017172756.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam03414
    Location:75 → 361
    Glyco_transf_6; Glycosyltransferase family 6

  6. XM_036160787.1 → XP_036016680.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3KPA1, Q8CJF3, Q8VI38
    Conserved Domains (1) summary
    pfam03414
    Location:60 → 346
    Glyco_transf_6; Glycosyltransferase family 6

  7. XM_017317268.2 → XP_017172757.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam03414
    Location:75 → 361
    Glyco_transf_6; Glycosyltransferase family 6

  8. XM_006497922.2 → XP_006497985.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X4

    Conserved Domains (1) summary
    pfam03414
    Location:13 → 299
    Glyco_transf_6; Glycosyltransferase family 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VI38.2 GenPept UniProtKB/Swiss-Prot:Q8VI38

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