U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Coq4 coenzyme Q4 [ Mus musculus (house mouse) ]

Gene ID: 227683, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Coq4provided by MGI
Official Full Name
coenzyme Q4provided by MGI
Primary source
MGI:MGI:1098826
See related
Ensembl:ENSMUSG00000026798 AllianceGenome:MGI:1098826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2Ertd97e
Summary
Predicted to be involved in ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; colon; gonad; heart; and lung. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7 and spastic ataxia. Orthologous to human COQ4 (coenzyme Q4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 15.4), duodenum adult (RPKM 13.3) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Coq4 in Genome Data Viewer
Location:
2 B; 2 20.62 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29677505..29687947)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29787493..29797935)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proline rich transmembrane protein 1B Neighboring gene STARR-seq mESC enhancer starr_04071 Neighboring gene predicted gene 13547 Neighboring gene TruB pseudouridine (psi) synthase family member 2 Neighboring gene STARR-seq mESC enhancer starr_04073 Neighboring gene predicted gene, 52595 Neighboring gene solute carrier family 27 (fatty acid transporter), member 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Spermatogonia-dependent expression of testicular genes in mice. Tanaka K, et al. Dev Biol, 2002 Jun 15. PMID 12051830
  2. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
  3. Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis. Belogrudov GI, et al. Arch Biochem Biophys, 2001 Aug 1. PMID 11469793
  4. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  5. Biochemistry of Mitochondrial Coenzyme Q Biosynthesis. Stefely JA, et al. Trends Biochem Sci, 2017 Oct. PMID 28927698, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • A330041N06

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquinone biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquinone biosynthesis complex IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
Names
coenzyme Q biosynthesis protein 4 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178693.5 → NP_848808.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

    See identical proteins and their annotated locations for NP_848808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK050459, AK163270, AL845323
    Consensus CDS
    CCDS15857.1
    UniProtKB/Swiss-Prot
    Q8BGB8
    UniProtKB/TrEMBL
    B9EID1, Q8BLS2
    Related
    ENSMUSP00000028137.4, ENSMUST00000028137.10
    Conserved Domains (1) summary
    pfam05019
    Location:63 → 259
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

RNA

  1. NR_145503.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice sites in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK163270, AL845323
    Related
    ENSMUST00000143616.8

  2. NR_145504.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK050459, AK163270, AL845323

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29677505..29687947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239076.4 → XP_011237378.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X2

    UniProtKB/TrEMBL
    D6RJJ8
    Related
    ENSMUSP00000135687.2, ENSMUST00000176348.8
    Conserved Domains (1) summary
    cl02093
    Location:63 → 126
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

  2. XM_017317287.3 → XP_017172776.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q8BLS2
    Conserved Domains (1) summary
    pfam05019
    Location:63 → 258
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

RNA

  1. XR_001782055.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGB8.1 GenPept UniProtKB/Swiss-Prot:Q8BGB8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous