U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zer1 zyg-11 related, cell cycle regulator [ Mus musculus (house mouse) ]

Gene ID: 227693, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Zer1provided by MGI
Official Full Name
zyg-11 related, cell cycle regulatorprovided by MGI
Primary source
MGI:MGI:2442511
See related
Ensembl:ENSMUSG00000039686 AllianceGenome:MGI:2442511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zyg11bl; C230075L19Rik
Summary
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 30.7), thymus adult (RPKM 30.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zer1 in Genome Data Viewer
Location:
2 B; 2 21.16 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29987295..30016299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30097283..30126287, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene SET nuclear oncogene Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene protein kinase N3 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873 Neighboring gene STARR-seq mESC enhancer starr_04088 Neighboring gene STARR-positive B cell enhancer ABC_E4427 Neighboring gene TBC1 domain family, member 13 Neighboring gene reactive oxygen species modulator 1 pseudogene Neighboring gene solute carrier family 39 (zinc transporter), member 1, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul2-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein zer-1 homolog
Names
zer-1 homolog
zyg-11 homolog B-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290503.1 → NP_001277432.1  protein zer-1 homolog isoform b

    See identical proteins and their annotated locations for NP_001277432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    BC048924, BC057021, BY749660
    Consensus CDS
    CCDS71017.1
    UniProtKB/TrEMBL
    Q3U297
    Related
    ENSMUSP00000109307.2, ENSMUST00000113677.3
    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  2. NM_178694.4 → NP_848809.2  protein zer-1 homolog isoform a

    See identical proteins and their annotated locations for NP_848809.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC048924, BY749660
    Consensus CDS
    CCDS15870.1
    UniProtKB/Swiss-Prot
    A2BEA2, Q6PGH5, Q80ZJ6, Q8BG38
    Related
    ENSMUSP00000046441.9, ENSMUST00000044751.14
    Conserved Domains (3) summary
    cd00020
    Location:529 → 655
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:575 → 613
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29987295..30016299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317305.3 → XP_017172794.1  protein zer-1 homolog isoform X1

    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  2. XM_036160810.1 → XP_036016703.1  protein zer-1 homolog isoform X3

    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560 → 598
    ARM; armadillo repeat [structural motif]

  3. XM_006497928.5 → XP_006497991.1  protein zer-1 homolog isoform X1

    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  4. XM_036160808.1 → XP_036016701.1  protein zer-1 homolog isoform X2

    UniProtKB/TrEMBL
    Q3U297
    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  5. XM_017317313.3 → XP_017172802.1  protein zer-1 homolog isoform X1

    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  6. XM_017317318.2 → XP_017172807.1  protein zer-1 homolog isoform X4

    Conserved Domains (1) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZJ6.1 GenPept UniProtKB/Swiss-Prot:Q80ZJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools