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Rabepk Rab9 effector protein with kelch motifs [ Mus musculus (house mouse) ]

Gene ID: 227746, updated on 28-Oct-2024

Summary

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Official Symbol
Rabepkprovided by MGI
Official Full Name
Rab9 effector protein with kelch motifsprovided by MGI
Primary source
MGI:MGI:2139530
See related
Ensembl:ENSMUSG00000070953 AllianceGenome:MGI:2139530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab9p40; 8430412M01Rik; 9530020D24Rik
Summary
Predicted to be located in intracellular membrane-bounded organelle. Is expressed in embryo. Orthologous to human RABEPK (Rab9 effector protein with kelch motifs). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 48.4), genital fat pad adult (RPKM 5.2) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Rabepk in Genome Data Viewer
Location:
2 B; 2 22.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34662946..34690200, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34774609..34800196, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34372 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene STARR-seq mESC enhancer starr_04265 Neighboring gene heat shock protein 5 Neighboring gene predicted gene, 53241 Neighboring gene STARR-seq mESC enhancer starr_04266 Neighboring gene STARR-seq mESC enhancer starr_04267 Neighboring gene F-box and WD-40 domain protein 2 Neighboring gene STARR-seq mESC enhancer starr_04268 Neighboring gene beta-1,3-galactosyltransferase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Luo S, et al. Mol Cell Biol, 2006 Aug. PMID 16847323, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rab9 effector protein with kelch motifs
Names
Rab9 effector p40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374669.1 → NP_001361598.1  rab9 effector protein with kelch motifs isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Consensus CDS
    CCDS89479.1
    UniProtKB/TrEMBL
    A2AUF7, B0R0S4
    Related
    ENSMUSP00000113099.2, ENSMUST00000118108.2
    Conserved Domains (4) summary
    PLN02193
    Location:126 → 294
    PLN02193; nitrile-specifier protein
    sd00038
    Location:86 → 135
    Kelch; KELCH repeat [structural motif]
    pfam07646
    Location:30 → 82
    Kelch_2; Kelch motif
    pfam13415
    Location:99 → 147
    Kelch_3; Galactose oxidase, central domain

  2. NM_145522.4 → NP_663497.2  rab9 effector protein with kelch motifs isoform 1

    See identical proteins and their annotated locations for NP_663497.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK035343, AL929106
    Consensus CDS
    CCDS15951.1
    UniProtKB/Swiss-Prot
    Q8BZG7, Q8VCH5
    UniProtKB/TrEMBL
    A2AUF7
    Related
    ENSMUSP00000122360.2, ENSMUST00000145903.8
    Conserved Domains (4) summary
    PLN02193
    Location:134 → 302
    PLN02193; nitrile-specifier protein
    sd00038
    Location:94 → 143
    Kelch; KELCH repeat [structural motif]
    pfam07646
    Location:38 → 90
    Kelch_2; Kelch motif
    pfam13415
    Location:107 → 155
    Kelch_3; Galactose oxidase, central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34662946..34690200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160906.1 → XP_036016799.1  rab9 effector protein with kelch motifs isoform X6

    Conserved Domains (4) summary
    PLN02193
    Location:133 → 283
    PLN02193; nitrile-specifier protein
    sd00038
    Location:94 → 142
    Kelch; KELCH repeat [structural motif]
    pfam07646
    Location:38 → 88
    Kelch_2; Kelch motif
    pfam13415
    Location:107 → 154
    Kelch_3; Galactose oxidase, central domain

  2. XM_017317453.3 → XP_017172942.1  rab9 effector protein with kelch motifs isoform X5

    Conserved Domains (4) summary
    PLN02193
    Location:134 → 284
    PLN02193; nitrile-specifier protein
    sd00038
    Location:94 → 143
    Kelch; KELCH repeat [structural motif]
    pfam07646
    Location:38 → 90
    Kelch_2; Kelch motif
    pfam13415
    Location:107 → 155
    Kelch_3; Galactose oxidase, central domain

  3. XM_036160907.1 → XP_036016800.1  rab9 effector protein with kelch motifs isoform X7

    Conserved Domains (4) summary
    PLN02193
    Location:126 → 276
    PLN02193; nitrile-specifier protein
    sd00038
    Location:86 → 135
    Kelch; KELCH repeat [structural motif]
    pfam07646
    Location:30 → 80
    Kelch_2; Kelch motif
    pfam13415
    Location:99 → 147
    Kelch_3; Galactose oxidase, central domain

  4. XM_030250015.2 → XP_030105875.1  rab9 effector protein with kelch motifs isoform X2

    UniProtKB/TrEMBL
    A2AUF7
    Conserved Domains (4) summary
    PLN02193
    Location:125 → 293
    PLN02193; nitrile-specifier protein
    sd00038
    Location:86 → 134
    Kelch; KELCH repeat [structural motif]
    pfam07646
    Location:30 → 82
    Kelch_2; Kelch motif
    pfam13415
    Location:99 → 146
    Kelch_3; Galactose oxidase, central domain

  5. XM_030250020.2 → XP_030105880.1  rab9 effector protein with kelch motifs isoform X4

    Conserved Domains (3) summary
    PLN02193
    Location:58 → 226
    PLN02193; nitrile-specifier protein
    sd00038
    Location:19 → 67
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:32 → 79
    Kelch_3; Galactose oxidase, central domain

  6. XM_006497987.5 → XP_006498050.1  rab9 effector protein with kelch motifs isoform X3

    See identical proteins and their annotated locations for XP_006498050.1

    Conserved Domains (3) summary
    PLN02193
    Location:59 → 227
    PLN02193; nitrile-specifier protein
    sd00038
    Location:19 → 68
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:32 → 80
    Kelch_3; Galactose oxidase, central domain

  7. XM_006497989.4 → XP_006498052.1  rab9 effector protein with kelch motifs isoform X9

    Conserved Domains (2) summary
    PLN02193
    Location:7 → 175
    PLN02193; nitrile-specifier protein
    sd00038
    Location:20 → 70
    Kelch; KELCH repeat [structural motif]

  8. XM_030250025.2 → XP_030105885.1  rab9 effector protein with kelch motifs isoform X8

    Conserved Domains (2) summary
    PLN02193
    Location:8 → 176
    PLN02193; nitrile-specifier protein
    sd00038
    Location:21 → 72
    Kelch; KELCH repeat [structural motif]

  9. XM_006497984.5 → XP_006498047.1  rab9 effector protein with kelch motifs isoform X1

    UniProtKB/TrEMBL
    A2AUF7
    Conserved Domains (4) summary
    PLN02193
    Location:133 → 301
    PLN02193; nitrile-specifier protein
    sd00038
    Location:94 → 142
    Kelch; KELCH repeat [structural motif]
    pfam07646
    Location:38 → 90
    Kelch_2; Kelch motif
    pfam13415
    Location:107 → 154
    Kelch_3; Galactose oxidase, central domain

  10. XM_030250019.2 → XP_030105879.1  rab9 effector protein with kelch motifs isoform X4

    Conserved Domains (3) summary
    PLN02193
    Location:58 → 226
    PLN02193; nitrile-specifier protein
    sd00038
    Location:19 → 67
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:32 → 79
    Kelch_3; Galactose oxidase, central domain

  11. XM_006497986.4 → XP_006498049.1  rab9 effector protein with kelch motifs isoform X3

    See identical proteins and their annotated locations for XP_006498049.1

    Conserved Domains (3) summary
    PLN02193
    Location:59 → 227
    PLN02193; nitrile-specifier protein
    sd00038
    Location:19 → 68
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:32 → 80
    Kelch_3; Galactose oxidase, central domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCH5.2 GenPept UniProtKB/Swiss-Prot:Q8VCH5

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