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Slc30a3 solute carrier family 30 (zinc transporter), member 3 [ Mus musculus (house mouse) ]

Gene ID: 22784, updated on 2-Nov-2024

Summary

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Official Symbol
Slc30a3provided by MGI
Official Full Name
solute carrier family 30 (zinc transporter), member 3provided by MGI
Primary source
MGI:MGI:1345280
See related
Ensembl:ENSMUSG00000029151 AllianceGenome:MGI:1345280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znt3
Summary
Enables zinc ion transmembrane transporter activity. Involved in zinc ion import into synaptic vesicle. Acts upstream of or within positive regulation of transport. Located in hippocampal mossy fiber. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; microvesicle; and synaptic vesicle membrane. Is expressed in several structures, including brain; metanephros; olfactory nerve; and spinal cord mantle layer. Orthologous to human SLC30A3 (solute carrier family 30 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 97.3), cortex adult (RPKM 39.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Slc30a3 in Genome Data Viewer
Location:
5 B1; 5 16.97 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31243450..31265576, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31086106..31108244, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene predicted gene, 38601 Neighboring gene predicted gene 9924 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene STARR-seq mESC enhancer starr_12766 Neighboring gene tripartite motif-containing 54 Neighboring gene predicted gene 15469

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission. Perez-Rosello T, et al. Neurobiol Dis, 2015 Sep. PMID 25796568, Free PMC Article
  2. SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. Smidt K, et al. PLoS One, 2009 May 25. PMID 19492079, Free PMC Article
  3. Intracellular Zn(2+) Signaling Facilitates Mossy Fiber Input-Induced Heterosynaptic Potentiation of Direct Cortical Inputs in Hippocampal CA3 Pyramidal Cells. Eom K, et al. J Neurosci, 2019 May 15. PMID 30833508, Free PMC Article
  4. Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse. Cole TB, et al. Brain Res, 2001 Feb 9. PMID 11164830
  5. Signaling by Synaptic Zinc is Required for Whisker-Mediated, Fine Texture Discrimination. Patrick Wu HP, et al. Neuroscience, 2018 Jan 15. PMID 29158108

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zinc transporter ZnT3/Slc30a3 has a potential role in zinc ion influx in mouse oocytes.
    Title: Zinc transporter ZnT3/Slc30a3 has a potential role in zinc ion influx in mouse oocytes.
  2. Trans-synaptic Association of Vesicular Zinc Transporter 3 and Shank3 Supports Synapse-Specific Dendritic Spine Structure and Function in the Mouse Auditory Cortex.
    Title: Trans-synaptic Association of Vesicular Zinc Transporter 3 and Shank3 Supports Synapse-Specific Dendritic Spine Structure and Function in the Mouse Auditory Cortex.
  3. Effects of social defeat stress and fluoxetine treatment on neurogenesis and behavior in mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
    Title: Effects of social defeat stress and fluoxetine treatment on neurogenesis and behavior in mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
  4. Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus.
    Title: Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus.
  5. Elevated zinc transporter ZnT3 in the dentate gyrus of mast cell-deficient mice.
    Title: Elevated zinc transporter ZnT3 in the dentate gyrus of mast cell-deficient mice.
  6. Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
    Title: Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
  7. Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome.
    Title: Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome.
  8. RNA-seq analysis showed a marked decrease in baseline levels of Slc30a3 mRNA in Mcoln1(-/-) mice.
    Title: ZnT3 expression levels are down-regulated in the brain of Mcoln1 knockout mice.
  9. ZnT3-/- mice showed reduced colchicine-induced dentate granule cell death.
    Title: ZnT3 Gene Deletion Reduces Colchicine-Induced Dentate Granule Cell Degeneration.
  10. the ZnT3 null state removed synaptic zinc, it rather increased free zinc in the cytosol of brain cells, which appeared to increase MMP-9 activity and BDNF levels. The present results suggest that zinc dyshomeostasis during the critical period of brain development may be a possible contributing mechanism for ASD.
    Title: Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in detoxification of zinc ion TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of zinc ion TAS
Traceable Author Statement
more info
 PubMed 
involved_in zinc ion import into lysosome IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion import into lysosome ISO
Inferred from Sequence Orthology
more info
  
involved_in zinc ion import into synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in zinc ion import into synaptic vesicle IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in zinc ion import into synaptic vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in zinc ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in hippocampal mossy fiber IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microvesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synaptic vesicle membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
probable proton-coupled zinc antiporter SLC30A3
Names
solute carrier family 30 member 3
zinc transporter 3
znT-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347323.2 → NP_001334252.1  probable proton-coupled zinc antiporter SLC30A3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC109608
    Consensus CDS
    CCDS84861.1
    UniProtKB/TrEMBL
    Q3UN07, Q6NZC3, S4R169
    Related
    ENSMUSP00000144566.2, ENSMUST00000202740.4
    Conserved Domains (1) summary
    TIGR01297
    Location:36 → 323
    CDF; cation diffusion facilitator family transporter

  2. NM_001425462.1 → NP_001412391.1  probable proton-coupled zinc antiporter SLC30A3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109608
    UniProtKB/TrEMBL
    S4R169

  3. NM_001425463.1 → NP_001412392.1  probable proton-coupled zinc antiporter SLC30A3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109608
    UniProtKB/TrEMBL
    S4R169

  4. NM_001425464.1 → NP_001412393.1  probable proton-coupled zinc antiporter SLC30A3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109608
    UniProtKB/TrEMBL
    S4R169

  5. NM_011773.4 → NP_035903.2  probable proton-coupled zinc antiporter SLC30A3 isoform 1

    See identical proteins and their annotated locations for NP_035903.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC109608
    Consensus CDS
    CCDS51455.1
    UniProtKB/Swiss-Prot
    P97441, P97511
    UniProtKB/TrEMBL
    Q3TMQ7, Q3UN07, Q6NZC3
    Related
    ENSMUSP00000031037.8, ENSMUST00000031037.14
    Conserved Domains (2) summary
    TIGR01297
    Location:85 → 372
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:85 → 293
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31243450..31265576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97441.1 GenPept UniProtKB/Swiss-Prot:P97441

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