Gca grancalcin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gcaprovided by MGI
Official Full Name: grancalcinprovided by MGI
Primary source: MGI:MGI:1918521
See related: Ensembl:ENSMUSG00000026893 AllianceGenome:MGI:1918521
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5133401E04Rik
Summary: Predicted to enable calcium ion binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be located in cytosol and plasma membrane. Is expressed in cerebral cortex ventricular layer and telencephalon ventricular layer. Orthologous to human GCA (grancalcin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 6.2), frontal lobe adult (RPKM 5.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.3; 2 36.47 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (62494671..62524453)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (62664327..62694109)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation in male mice.
Title: Myeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation in male mice.
Homozygous Gca mutants appeared healthy and reproduced normally. Leukocyte recruitment into the peritoneal cavity upon induction of inflammation was not significantly affected by the absence of grancalcin.
Title: Granulocyte function in grancalcin-deficient mice.
Adhesion to fibronectin of grancalcin-deficient neutrophils was decreased by 60% compared to control cells.
Title: The role of grancalcin in adhesion of neutrophils.
findings suggest that grancalcin plays a key role in leukocyte-specific functions that are responsible for host defense
Title: Characterization of murine grancalcin specifically expressed in leukocytes and its possible role in host defense against bacterial infection.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

AI573844 (e-PCR)
- UniSTS:178629

BB403260 (e-PCR)
- UniSTS:207336

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: grancalcin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145523.3 → NP_663498.1 grancalcin

See identical proteins and their annotated locations for NP_663498.1

Status: PROVISIONAL

Source sequence(s)

AK078915

Consensus CDS

CCDS16069.1

UniProtKB/Swiss-Prot

Q8BL53, Q8K3Z6, Q8VC88

Related

ENSMUSP00000028257.3, ENSMUST00000028257.3

Conserved Domains (3) summary

cd00051
Location:67 → 122

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:128 → 183

EF-hand_7; EF-hand domain pair

cl08302
Location:97 → 152

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...