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ZNF652 zinc finger protein 652 [ Homo sapiens (human) ]

Gene ID: 22834, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF652provided by HGNC
Official Full Name
zinc finger protein 652provided by HGNC
Primary source
HGNC:HGNC:29147
See related
Ensembl:ENSG00000198740 MIM:613907; AllianceGenome:HGNC:29147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in skin (RPKM 5.2), testis (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF652 in Genome Data Viewer
Location:
17q21.32-q21.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49288117..49362473, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50152285..50225479, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47366568..47439835, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904022 Neighboring gene uncharacterized FLJ40194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47338142-47338954 Neighboring gene microRNA 6129 Neighboring gene MPRA-validated peak2884 silencer Neighboring gene U7 small nuclear RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8667 Neighboring gene MPRA-validated peak2885 silencer Neighboring gene MPRA-validated peak2886 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8668 Neighboring gene ZNF652 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12361 Neighboring gene prohibitin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer. Laitinen VH, et al. Int J Cancer, 2015 May 15. PMID 25335771, Free PMC Article
  2. ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666. Ke H, et al. J Immunol Res, 2021. PMID 34926705, Free PMC Article
  3. Genome-wide mapping of ZNF652 promoter binding sites in breast cancer cells. Kumar R, et al. J Cell Biochem, 2011 Oct. PMID 21678463
  4. Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p. Cheng C, et al. Bioengineered, 2021 Dec. PMID 34424826, Free PMC Article
  5. Co-expression of the androgen receptor and the transcription factor ZNF652 is related to prostate cancer outcome. Callen DF, et al. Oncol Rep, 2010 Apr. PMID 20204290

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666.
    Title: ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666.
  2. Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p.
    Title: Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p.
  3. Genetic association studies identify a novel variant in ZNF652 gene suggesting its role in prostate cancer.
    Title: Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer.
  4. De novo motif scanning of the ZNF652 binding sites identified a novel ZNF652 recognition motif that closely resembles the previously characterised in vitro binding site, being a 10 nucleotide core of that 13 nucleotide sequence.
    Title: Genome-wide mapping of ZNF652 promoter binding sites in breast cancer cells.
  5. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study.
  6. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
  7. variation in FGF5 and ZNF652 gene upstream regions with altered susceptibility to hypertension in Han Chinese
    Title: Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese.
  9. High levels of expression of both the androgen receptor and ZNF652 in clinically organ-defined prostate cancer are associated with a statistically increased risk of relapse
    Title: Co-expression of the androgen receptor and the transcription factor ZNF652 is related to prostate cancer outcome.
  10. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association study identifies eight loci associated with blood pressure.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
EBI GWAS Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0924, DKFZp781E2122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 652

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145365.3 → NP_001138837.1  zinc finger protein 652

    See identical proteins and their annotated locations for NP_001138837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004797, AC091180, AK292667, BC152440, DN998934
    Consensus CDS
    CCDS32677.1
    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9
    UniProtKB/TrEMBL
    A8K9F2
    Related
    ENSP00000416305.2, ENST00000430262.3
    Conserved Domains (4) summary
    COG5048
    Location:439 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381 → 464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387 → 407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240 → 304
    UFD1; Ubiquitin fusion degradation protein UFD1

  2. NM_014897.2 → NP_055712.1  zinc finger protein 652

    See identical proteins and their annotated locations for NP_055712.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004797, BC152440
    Consensus CDS
    CCDS32677.1
    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9
    UniProtKB/TrEMBL
    A8K9F2
    Related
    ENSP00000354686.2, ENST00000362063.6
    Conserved Domains (4) summary
    COG5048
    Location:439 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381 → 464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387 → 407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240 → 304
    UFD1; Ubiquitin fusion degradation protein UFD1

RNA

  1. NR_135579.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091180, BC034987, BF763222, BU838341, CN371383, DN998934

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    49288117..49362473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435629.1 → XP_047291585.1  zinc finger protein 652 isoform X2

    UniProtKB/TrEMBL
    D6RF85

  2. XM_047435628.1 → XP_047291584.1  zinc finger protein 652 isoform X2

    UniProtKB/TrEMBL
    D6RF85

  3. XM_047435626.1 → XP_047291582.1  zinc finger protein 652 isoform X1

    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9

  4. XM_024450656.2 → XP_024306424.1  zinc finger protein 652 isoform X2

    UniProtKB/TrEMBL
    D6RF85
    Related
    ENSP00000424848.1, ENST00000508237.5

  5. XM_024450653.2 → XP_024306421.1  zinc finger protein 652 isoform X1

    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9
    UniProtKB/TrEMBL
    A8K9F2
    Conserved Domains (4) summary
    COG5048
    Location:439 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381 → 464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387 → 407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240 → 304
    UFD1; Ubiquitin fusion degradation protein UFD1

  6. XM_047435627.1 → XP_047291583.1  zinc finger protein 652 isoform X1

    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9

  7. XM_024450655.2 → XP_024306423.1  zinc finger protein 652 isoform X1

    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9
    UniProtKB/TrEMBL
    A8K9F2
    Conserved Domains (4) summary
    COG5048
    Location:439 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381 → 464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387 → 407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240 → 304
    UFD1; Ubiquitin fusion degradation protein UFD1

RNA

  1. XR_934423.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    50152285..50225479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315490.1 → XP_054171465.1  zinc finger protein 652 isoform X2

    UniProtKB/TrEMBL
    D6RF85

  2. XM_054315489.1 → XP_054171464.1  zinc finger protein 652 isoform X2

    UniProtKB/TrEMBL
    D6RF85

  3. XM_054315484.1 → XP_054171459.1  zinc finger protein 652 isoform X1

    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9

  4. XM_054315488.1 → XP_054171463.1  zinc finger protein 652 isoform X2

    UniProtKB/TrEMBL
    D6RF85

  5. XM_054315485.1 → XP_054171460.1  zinc finger protein 652 isoform X1

    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9

  6. XM_054315486.1 → XP_054171461.1  zinc finger protein 652 isoform X1

    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9

  7. XM_054315487.1 → XP_054171462.1  zinc finger protein 652 isoform X1

    UniProtKB/Swiss-Prot
    A4QPD9, Q5H9Q0, Q9Y2D9

RNA

  1. XR_008484798.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2D9.3 GenPept UniProtKB/Swiss-Prot:Q9Y2D9

Gene LinkOut

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