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ANKRD6 ankyrin repeat domain 6 [ Homo sapiens (human) ]

Gene ID: 22881, updated on 3-Apr-2024

Summary

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Official Symbol
ANKRD6provided by HGNC
Official Full Name
ankyrin repeat domain 6provided by HGNC
Primary source
HGNC:HGNC:17280
See related
Ensembl:ENSG00000135299 MIM:610583; AllianceGenome:HGNC:17280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of JNK cascade. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 8.1), ovary (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6q15
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (89433152..89633834)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (90642513..90843208)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90142871..90343553)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24824 Neighboring gene Sharpr-MPRA regulatory region 13381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90084816-90085316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90085317-90085817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24828 Neighboring gene Ras related GTP binding D Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17394 Neighboring gene uncharacterized LOC124901360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17395 Neighboring gene MPRA-validated peak5952 silencer Neighboring gene NACA pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 11, pseudogene Neighboring gene uncharacterized LOC105377889 Neighboring gene OCT4 hESC enhancer GRCh37_chr6:90262750-90263251 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:90265242-90265742 Neighboring gene uncharacterized LOC124901359 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:90319101-90319300 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:90347214-90348413 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:90367565-90368764 Neighboring gene MDN1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 852 Neighboring gene LYR motif containing 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:90399309-90399858 Neighboring gene midasin AAA ATPase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90405104-90405604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90405605-90406105 Neighboring gene NANOG hESC enhancer GRCh37_chr6:90430881-90431382 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Diversin upregulates the proliferative ability of colorectal cancer by inducing cell cycle proteins. Luan L, et al. Exp Mol Pathol, 2023 Feb. PMID 36623636
  2. Genetic studies of ANKRD6 as a molecular switch between Wnt signaling pathways in human neural tube defects. Allache R, et al. Birth Defects Res A Clin Mol Teratol, 2015 Jan. PMID 25200652
  3. Diversin is overexpressed in breast cancer and accelerates cell proliferation and invasion. Yu X, et al. PLoS One, 2014. PMID 24858714, Free PMC Article
  4. Diversin is overexpressed in human gliomas and its depletion inhibits proliferation and invasion. Wang M, et al. Tumour Biol, 2014 Aug. PMID 24833088
  5. Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults. Van Deveire KN, et al. J Strength Cond Res, 2012 Jul. PMID 22580979, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diversin upregulates the proliferative ability of colorectal cancer by inducing cell cycle proteins.
    Title: Diversin upregulates the proliferative ability of colorectal cancer by inducing cell cycle proteins.
  2. missense mutations in ANKRD6 are associated with neural tube defects.
    Title: Genetic studies of ANKRD6 as a molecular switch between Wnt signaling pathways in human neural tube defects.
  3. study demonstrated that diversin was overexpressed in human breast cancers. Diversin could contribute to breast cancer cell proliferation and invasion.
    Title: Diversin is overexpressed in breast cancer and accelerates cell proliferation and invasion.
  4. diversin is overexpressed in human glioma and regulates glioma cell proliferation and invasion, possibly through MMP9
    Title: Diversin is overexpressed in human gliomas and its depletion inhibits proliferation and invasion.
  5. ANKRD6 genetic variants were associated with the muscle size and strength response to resistance training and habitual physical activity levels.
    Title: Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults.
  6. Diversin, containing several nuclear localization signals, translocates to the nucleus, where it interacts with the transcription factor AF9.
    Title: The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of ankyrin repeat domain 6 (ANKRD6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12637, FLJ34916

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 6
Names
diego homolog
diversin
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242809.2 → NP_001229738.1  ankyrin repeat domain-containing protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same longest isoform (a).
    Source sequence(s)
    AK295731, AL096678, AL138717, DN999929
    Consensus CDS
    CCDS56441.1
    UniProtKB/Swiss-Prot
    B3KUC3, Q5JUJ4, Q5JUJ5, Q8IUQ8, Q9NU24, Q9UFQ9, Q9Y2G4
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000345767.4, ENST00000339746.9
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:141 → 171
    ANK; ANK repeat [structural motif]
    NF033885
    Location:632 → 724
    conj_TraP_IncI1; conjugal transfer protein TraP

  2. NM_001242811.1 → NP_001229740.1  ankyrin repeat domain-containing protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, and encodes the same isoform a, compared to variant 1.
    Source sequence(s)
    AK295731, AL096678, BC042173, DC317010
    Consensus CDS
    CCDS56441.1
    UniProtKB/Swiss-Prot
    B3KUC3, Q5JUJ4, Q5JUJ5, Q8IUQ8, Q9NU24, Q9UFQ9, Q9Y2G4
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000430985.1, ENST00000522441.5
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:141 → 171
    ANK; ANK repeat [structural motif]
    NF033885
    Location:632 → 724
    conj_TraP_IncI1; conjugal transfer protein TraP

  3. NM_001242813.1 → NP_001229742.1  ankyrin repeat domain-containing protein 6 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AB023174, AK295731, AL096678, DN999929
    Consensus CDS
    CCDS56442.1
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000358416.5, ENST00000369408.9
    Conserved Domains (3) summary
    cd00204
    Location:102 → 227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141 → 171
    ANK; ANK repeat [structural motif]
    cl26072
    Location:190 → 270
    Ank_5; Ankyrin repeats (many copies)

  4. NM_001242814.1 → NP_001229743.1  ankyrin repeat domain-containing protein 6 isoform d

    See identical proteins and their annotated locations for NP_001229743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (d) lacks two internal segments, compared to isoform a.
    Source sequence(s)
    AB023174, AK096867, AL096678
    Consensus CDS
    CCDS56443.1
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000429782.1, ENST00000520793.5
    Conserved Domains (5) summary
    cd00204
    Location:37 → 161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:174 → 205
    Ank; Ankyrin repeat
    pfam12796
    Location:112 → 204
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:14 → 62
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:108 → 138
    ANK; ANK repeat [structural motif]

  5. NM_014942.4 → NP_055757.3  ankyrin repeat domain-containing protein 6 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the coding region, and the open reading frame is retained, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AK295731, AL096678, BC042173, DN999929
    Consensus CDS
    CCDS47460.1
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000396771.2, ENST00000447838.6
    Conserved Domains (3) summary
    cd00204
    Location:102 → 227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141 → 171
    ANK; ANK repeat [structural motif]
    cl26073
    Location:127 → 382
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    89433152..89633834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418408.1 → XP_047274364.1  ankyrin repeat domain-containing protein 6 isoform X34

  2. XM_047418410.1 → XP_047274366.1  ankyrin repeat domain-containing protein 6 isoform X34

  3. XM_047418412.1 → XP_047274368.1  ankyrin repeat domain-containing protein 6 isoform X34

  4. XM_047418413.1 → XP_047274369.1  ankyrin repeat domain-containing protein 6 isoform X34

  5. XM_047418415.1 → XP_047274371.1  ankyrin repeat domain-containing protein 6 isoform X34

  6. XM_005248681.3 → XP_005248738.1  ankyrin repeat domain-containing protein 6 isoform X38

    See identical proteins and their annotated locations for XP_005248738.1

    UniProtKB/Swiss-Prot
    B3KUC3, Q5JUJ4, Q5JUJ5, Q8IUQ8, Q9NU24, Q9UFQ9, Q9Y2G4
    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:141 → 171
    ANK; ANK repeat [structural motif]
    NF033885
    Location:632 → 724
    conj_TraP_IncI1; conjugal transfer protein TraP

  7. XM_047418398.1 → XP_047274354.1  ankyrin repeat domain-containing protein 6 isoform X4

  8. XM_047418401.1 → XP_047274357.1  ankyrin repeat domain-containing protein 6 isoform X11

  9. XM_047418405.1 → XP_047274361.1  ankyrin repeat domain-containing protein 6 isoform X21

  10. XM_017010513.2 → XP_016866002.1  ankyrin repeat domain-containing protein 6 isoform X33

    Conserved Domains (3) summary
    cd00204
    Location:14 → 128
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    cl26073
    Location:42 → 222
    Ank_2; Ankyrin repeats (3 copies)

  11. XM_047418409.1 → XP_047274365.1  ankyrin repeat domain-containing protein 6 isoform X35

  12. XM_047418402.1 → XP_047274358.1  ankyrin repeat domain-containing protein 6 isoform X13

  13. XM_024446357.2 → XP_024302125.1  ankyrin repeat domain-containing protein 6 isoform X4

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (3) summary
    cd00204
    Location:102 → 227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141 → 171
    ANK; ANK repeat [structural motif]
    cl26073
    Location:127 → 382
    Ank_2; Ankyrin repeats (3 copies)

  14. XM_024446359.2 → XP_024302127.1  ankyrin repeat domain-containing protein 6 isoform X14

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (3) summary
    cd00204
    Location:102 → 227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141 → 171
    ANK; ANK repeat [structural motif]
    cl26072
    Location:190 → 270
    Ank_5; Ankyrin repeats (many copies)

  15. XM_024446361.2 → XP_024302129.1  ankyrin repeat domain-containing protein 6 isoform X16

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (3) summary
    cd00204
    Location:102 → 227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141 → 171
    ANK; ANK repeat [structural motif]
    cl26072
    Location:190 → 270
    Ank_5; Ankyrin repeats (many copies)

  16. XM_047418399.1 → XP_047274355.1  ankyrin repeat domain-containing protein 6 isoform X9

  17. XM_047418400.1 → XP_047274356.1  ankyrin repeat domain-containing protein 6 isoform X10

  18. XM_024446358.2 → XP_024302126.1  ankyrin repeat domain-containing protein 6 isoform X11

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (2) summary
    cd00204
    Location:37 → 161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]

  19. XM_024446360.2 → XP_024302128.1  ankyrin repeat domain-containing protein 6 isoform X15

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (2) summary
    cd00204
    Location:37 → 161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]

  20. XM_024446363.2 → XP_024302131.1  ankyrin repeat domain-containing protein 6 isoform X24

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (2) summary
    cd00204
    Location:37 → 161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]

  21. XM_024446362.2 → XP_024302130.1  ankyrin repeat domain-containing protein 6 isoform X21

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (3) summary
    cd00204
    Location:37 → 161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:141 → 193
    Ank_4; Ankyrin repeats (many copies)

  22. XM_024446364.2 → XP_024302132.1  ankyrin repeat domain-containing protein 6 isoform X25

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (3) summary
    cd00204
    Location:37 → 161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:141 → 193
    Ank_4; Ankyrin repeats (many copies)

  23. XM_024446366.2 → XP_024302134.1  ankyrin repeat domain-containing protein 6 isoform X30

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (3) summary
    cd00204
    Location:37 → 161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:141 → 193
    Ank_4; Ankyrin repeats (many copies)

  24. XM_047418407.1 → XP_047274363.1  ankyrin repeat domain-containing protein 6 isoform X28

  25. XM_024446368.2 → XP_024302136.1  ankyrin repeat domain-containing protein 6 isoform X33

    Conserved Domains (3) summary
    cd00204
    Location:14 → 128
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    cl26073
    Location:42 → 222
    Ank_2; Ankyrin repeats (3 copies)

  26. XM_047418404.1 → XP_047274360.1  ankyrin repeat domain-containing protein 6 isoform X20

  27. XM_024446365.2 → XP_024302133.1  ankyrin repeat domain-containing protein 6 isoform X26

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (3) summary
    cd00204
    Location:37 → 161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:141 → 193
    Ank_4; Ankyrin repeats (many copies)

  28. XM_017010496.3 → XP_016865985.1  ankyrin repeat domain-containing protein 6 isoform X12

    UniProtKB/TrEMBL
    B7Z3D2
    Conserved Domains (4) summary
    cd00204
    Location:69 → 194
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:112 → 204
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:14 → 62
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:108 → 138
    ANK; ANK repeat [structural motif]

  29. XM_017010502.3 → XP_016865991.1  ankyrin repeat domain-containing protein 6 isoform X22

    UniProtKB/TrEMBL
    B7Z3D2

  30. XM_017010508.2 → XP_016865997.1  ankyrin repeat domain-containing protein 6 isoform X29

    UniProtKB/TrEMBL
    B7Z3D2

  31. XM_017010511.3 → XP_016866000.1  ankyrin repeat domain-containing protein 6 isoform X31

    UniProtKB/TrEMBL
    B7Z3D2

  32. XM_047418411.1 → XP_047274367.1  ankyrin repeat domain-containing protein 6 isoform X36

  33. XM_017010503.2 → XP_016865992.1  ankyrin repeat domain-containing protein 6 isoform X23

    UniProtKB/TrEMBL
    B7Z3D2

  34. XM_005248679.4 → XP_005248736.1  ankyrin repeat domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0AA34QVS0
    Related
    ENSP00000518190.1, ENST00000710308.1
    Conserved Domains (3) summary
    cd00204
    Location:127 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:170 → 262
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:166 → 196
    ANK; ANK repeat [structural motif]

  35. XM_047418397.1 → XP_047274353.1  ankyrin repeat domain-containing protein 6 isoform X2

  36. XM_017010493.2 → XP_016865982.1  ankyrin repeat domain-containing protein 6 isoform X7

  37. XM_005248682.4 → XP_005248739.1  ankyrin repeat domain-containing protein 6 isoform X3

    Conserved Domains (3) summary
    cd00204
    Location:127 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:170 → 262
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:166 → 196
    ANK; ANK repeat [structural motif]

  38. XM_011535596.3 → XP_011533898.1  ankyrin repeat domain-containing protein 6 isoform X5

    Conserved Domains (4) summary
    cd00204
    Location:127 → 251
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:102 → 153
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:132 → 163
    ANK; ANK repeat [structural motif]

  39. XM_017010494.2 → XP_016865983.1  ankyrin repeat domain-containing protein 6 isoform X8

  40. XM_017010499.2 → XP_016865988.1  ankyrin repeat domain-containing protein 6 isoform X18

  41. XM_005248683.4 → XP_005248740.1  ankyrin repeat domain-containing protein 6 isoform X17

    Conserved Domains (3) summary
    cd00204
    Location:101 → 218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:104 → 196
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:101 → 130
    ANK; ANK repeat [structural motif]

  42. XM_017010500.2 → XP_016865989.1  ankyrin repeat domain-containing protein 6 isoform X19

  43. XM_005248684.4 → XP_005248741.1  ankyrin repeat domain-containing protein 6 isoform X32

    Conserved Domains (3) summary
    cd00204
    Location:101 → 173
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:102 → 153
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:98 → 130
    ANK; ANK repeat [structural motif]

  44. XM_011535597.3 → XP_011533899.1  ankyrin repeat domain-containing protein 6 isoform X6

    Conserved Domains (4) summary
    cd00204
    Location:127 → 251
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:102 → 153
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:133 → 163
    ANK; ANK repeat [structural motif]

  45. XM_047418406.1 → XP_047274362.1  ankyrin repeat domain-containing protein 6 isoform X27

  46. XM_047418414.1 → XP_047274370.1  ankyrin repeat domain-containing protein 6 isoform X37

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    90642513..90843208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354721.1 → XP_054210696.1  ankyrin repeat domain-containing protein 6 isoform X34

  2. XM_054354723.1 → XP_054210698.1  ankyrin repeat domain-containing protein 6 isoform X34

  3. XM_054354725.1 → XP_054210700.1  ankyrin repeat domain-containing protein 6 isoform X34

  4. XM_054354726.1 → XP_054210701.1  ankyrin repeat domain-containing protein 6 isoform X34

  5. XM_054354728.1 → XP_054210703.1  ankyrin repeat domain-containing protein 6 isoform X34

  6. XM_054354691.1 → XP_054210666.1  ankyrin repeat domain-containing protein 6 isoform X4

    UniProtKB/TrEMBL
    A0A384MEC3

  7. XM_054354701.1 → XP_054210676.1  ankyrin repeat domain-containing protein 6 isoform X14

  8. XM_054354703.1 → XP_054210678.1  ankyrin repeat domain-containing protein 6 isoform X16

  9. XM_054354696.1 → XP_054210671.1  ankyrin repeat domain-containing protein 6 isoform X9

  10. XM_054354697.1 → XP_054210672.1  ankyrin repeat domain-containing protein 6 isoform X10

  11. XM_054354698.1 → XP_054210673.1  ankyrin repeat domain-containing protein 6 isoform X11

  12. XM_054354702.1 → XP_054210677.1  ankyrin repeat domain-containing protein 6 isoform X15

  13. XM_054354711.1 → XP_054210686.1  ankyrin repeat domain-containing protein 6 isoform X24

  14. XM_054354708.1 → XP_054210683.1  ankyrin repeat domain-containing protein 6 isoform X21

  15. XM_054354712.1 → XP_054210687.1  ankyrin repeat domain-containing protein 6 isoform X25

  16. XM_054354717.1 → XP_054210692.1  ankyrin repeat domain-containing protein 6 isoform X30

  17. XM_054354715.1 → XP_054210690.1  ankyrin repeat domain-containing protein 6 isoform X28

  18. XM_054354720.1 → XP_054210695.1  ankyrin repeat domain-containing protein 6 isoform X33

  19. XM_054354707.1 → XP_054210682.1  ankyrin repeat domain-containing protein 6 isoform X20

  20. XM_054354713.1 → XP_054210688.1  ankyrin repeat domain-containing protein 6 isoform X26

  21. XM_054354699.1 → XP_054210674.1  ankyrin repeat domain-containing protein 6 isoform X12

  22. XM_054354709.1 → XP_054210684.1  ankyrin repeat domain-containing protein 6 isoform X22

  23. XM_054354716.1 → XP_054210691.1  ankyrin repeat domain-containing protein 6 isoform X29

  24. XM_054354718.1 → XP_054210693.1  ankyrin repeat domain-containing protein 6 isoform X31

  25. XM_054354724.1 → XP_054210699.1  ankyrin repeat domain-containing protein 6 isoform X36

  26. XM_054354710.1 → XP_054210685.1  ankyrin repeat domain-containing protein 6 isoform X23

  27. XM_054354722.1 → XP_054210697.1  ankyrin repeat domain-containing protein 6 isoform X35

  28. XM_054354700.1 → XP_054210675.1  ankyrin repeat domain-containing protein 6 isoform X13

  29. XM_054354688.1 → XP_054210663.1  ankyrin repeat domain-containing protein 6 isoform X1

  30. XM_054354689.1 → XP_054210664.1  ankyrin repeat domain-containing protein 6 isoform X2

  31. XM_054354694.1 → XP_054210669.1  ankyrin repeat domain-containing protein 6 isoform X7

  32. XM_054354690.1 → XP_054210665.1  ankyrin repeat domain-containing protein 6 isoform X3

  33. XM_054354692.1 → XP_054210667.1  ankyrin repeat domain-containing protein 6 isoform X5

  34. XM_054354695.1 → XP_054210670.1  ankyrin repeat domain-containing protein 6 isoform X8

  35. XM_054354705.1 → XP_054210680.1  ankyrin repeat domain-containing protein 6 isoform X18

  36. XM_054354704.1 → XP_054210679.1  ankyrin repeat domain-containing protein 6 isoform X17

  37. XM_054354706.1 → XP_054210681.1  ankyrin repeat domain-containing protein 6 isoform X19

  38. XM_054354719.1 → XP_054210694.1  ankyrin repeat domain-containing protein 6 isoform X32

  39. XM_054354693.1 → XP_054210668.1  ankyrin repeat domain-containing protein 6 isoform X6

  40. XM_054354714.1 → XP_054210689.1  ankyrin repeat domain-containing protein 6 isoform X27

  41. XM_054354727.1 → XP_054210702.1  ankyrin repeat domain-containing protein 6 isoform X37

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2G4.3 GenPept UniProtKB/Swiss-Prot:Q9Y2G4

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