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ZHX2 zinc fingers and homeoboxes 2 [ Homo sapiens (human) ]

Gene ID: 22882, updated on 2-Nov-2024

Summary

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Official Symbol
ZHX2provided by HGNC
Official Full Name
zinc fingers and homeoboxes 2provided by HGNC
Primary source
HGNC:HGNC:18513
See related
Ensembl:ENSG00000178764 MIM:609185; AllianceGenome:HGNC:18513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAF; AFR1
Summary
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 11.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZHX2 in Genome Data Viewer
Location:
8q24.13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (122780379..122974510)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (123911550..124105660)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (123792618..123986750)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27852 Neighboring gene Sharpr-MPRA regulatory region 2746 Neighboring gene hESC enhancers GRCh37_chr8:123770608-123771162 and GRCh37_chr8:123771163-123771718 Neighboring gene uncharacterized LOC124902012 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:123792337-123792838 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:123792839-123793338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27853 Neighboring gene NANOG hESC enhancer GRCh37_chr8:123795211-123795745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27854 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:123799669-123800426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27857 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:123809400-123810599 Neighboring gene cyclin dependent kinase 5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:123814233-123815192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:123815193-123816150 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:123817802-123819001 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:123848010-123849209 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:123849857-123850688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:123869217-123869717 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:123874507-123875706 Neighboring gene uncharacterized LOC124902011 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:123927788-123928344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:123960147-123960646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19492 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:124000413-124001612 Neighboring gene uncharacterized LOC124902013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27866 Neighboring gene derlin 1 Neighboring gene RNY4 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Proliferation and osteo/odontogenic differentiation of stem cells from apical papilla regulated by Zinc fingers and homeoboxes 2: An in vitro study. Wan F, et al. Biochem Biophys Res Commun, 2016 Jan 15. PMID 26679602
  2. Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma. Nagel S, et al. Leuk Res, 2012 May. PMID 22078940
  3. ZHX2 restricts hepatocellular carcinoma by suppressing stem cell-like traits through KDM2A-mediated H3K36 demethylation. Lin Q, et al. EBioMedicine, 2020 Mar. PMID 32114388, Free PMC Article
  4. ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma. Zhu L, et al. Cell Death Dis, 2020 May 7. PMID 32382017, Free PMC Article
  5. Zinc fingers and homeoboxes 2 inhibition could suppress the proliferation of ovarian cancer cells by apoptosis pathway. Ding R, et al. Clin Transl Oncol, 2023 Jul. PMID 36746874

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor Property of Renal Cell Carcinoma.
    Title: METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor Property of Renal Cell Carcinoma.
  2. Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression.
    Title: Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression.
  3. Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response.
    Title: Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response.
  4. Zinc fingers and homeoboxes 2 inhibition could suppress the proliferation of ovarian cancer cells by apoptosis pathway.
    Title: Zinc fingers and homeoboxes 2 inhibition could suppress the proliferation of ovarian cancer cells by apoptosis pathway.
  5. USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.
    Title: USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.
  6. Upregulation of ZHX2 predicts poor prognosis and is correlated with immune infiltration in gastric cancer.
    Title: Upregulation of ZHX2 predicts poor prognosis and is correlated with immune infiltration in gastric cancer.
  7. Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity.
    Title: Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity.
  8. HNRNPD interacts with ZHX2 regulating the vasculogenic mimicry formation of glioma cells via linc00707/miR-651-3p/SP2 axis.
    Title: HNRNPD interacts with ZHX2 regulating the vasculogenic mimicry formation of glioma cells via linc00707/miR-651-3p/SP2 axis.
  9. The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.
    Title: The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.
  10. Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake.
    Title: Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
EBI GWAS Catalog
Genome-wide association study of antibody response to smallpox vaccine.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0854

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinal bipolar neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc fingers and homeoboxes protein 2
Names
AFP regulator 1
alpha-fetoprotein regulator 1
regulator of AFP
transcription factor ZHX2
zinc finger and homeodomain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046951.1 RefSeqGene

    Range
    5307..198162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001362797.2 → NP_001349726.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316, BC042145, BM148156, HY099683
    Consensus CDS
    CCDS6336.1
    UniProtKB/Swiss-Prot
    Q9Y6X8
    Conserved Domains (2) summary
    smart00389
    Location:537 → 582
    HOX; Homeodomain
    cd00086
    Location:444 → 496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  2. NM_001412796.1 → NP_001399725.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  3. NM_001412797.1 → NP_001399726.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  4. NM_001412798.1 → NP_001399727.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  5. NM_001412799.1 → NP_001399728.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  6. NM_001412800.1 → NP_001399729.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  7. NM_001412801.1 → NP_001399730.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  8. NM_001412802.1 → NP_001399731.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  9. NM_001412803.1 → NP_001399732.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  10. NM_001412804.1 → NP_001399733.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  11. NM_001412805.1 → NP_001399734.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  12. NM_001412806.1 → NP_001399735.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  13. NM_001412807.1 → NP_001399736.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  14. NM_001412808.1 → NP_001399737.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  15. NM_001412809.1 → NP_001399738.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  16. NM_001412810.1 → NP_001399739.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  17. NM_001412811.1 → NP_001399740.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  18. NM_001412812.1 → NP_001399741.1  zinc fingers and homeoboxes protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316
    UniProtKB/Swiss-Prot
    Q9Y6X8

  19. NM_001412813.1 → NP_001399742.1  zinc fingers and homeoboxes protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316

  20. NM_014943.5 → NP_055758.1  zinc fingers and homeoboxes protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055758.1

    Status: REVIEWED

    Source sequence(s)
    AC104316, BC042145, BM148156, HY099683
    Consensus CDS
    CCDS6336.1
    UniProtKB/Swiss-Prot
    Q9Y6X8
    Related
    ENSP00000314709.4, ENST00000314393.6
    Conserved Domains (2) summary
    smart00389
    Location:537 → 582
    HOX; Homeodomain
    cd00086
    Location:444 → 496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RNA

  1. NR_182048.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    122780379..122974510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421590.1 → XP_047277546.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8

  2. XM_011516932.4 → XP_011515234.1  zinc fingers and homeoboxes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011515234.1

    UniProtKB/Swiss-Prot
    Q9Y6X8
    Conserved Domains (2) summary
    smart00389
    Location:537 → 582
    HOX; Homeodomain
    cd00086
    Location:444 → 496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  3. XM_005250836.6 → XP_005250893.1  zinc fingers and homeoboxes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005250893.1

    UniProtKB/Swiss-Prot
    Q9Y6X8
    Conserved Domains (2) summary
    smart00389
    Location:537 → 582
    HOX; Homeodomain
    cd00086
    Location:444 → 496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  4. XM_047421589.1 → XP_047277545.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8

  5. XM_047421588.1 → XP_047277544.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    123911550..124105660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360145.1 → XP_054216120.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8

  2. XM_054360144.1 → XP_054216119.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8

  3. XM_054360142.1 → XP_054216117.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8

  4. XM_054360141.1 → XP_054216116.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8

  5. XM_054360143.1 → XP_054216118.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6X8.1 GenPept UniProtKB/Swiss-Prot:Q9Y6X8

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