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ZBTB1 zinc finger and BTB domain containing 1 [ Homo sapiens (human) ]

Gene ID: 22890, updated on 28-Oct-2024

Summary

Official Symbol
ZBTB1provided by HGNC
Official Full Name
zinc finger and BTB domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20259
See related
Ensembl:ENSG00000126804 MIM:616578; AllianceGenome:HGNC:20259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF909
Summary
Enables K63-linked polyubiquitin modification-dependent protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including mRNA transcription by RNA polymerase II; protein homooligomerization; and translesion synthesis. Located in nuclear body and nuclear membrane. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 14.1), lymph node (RPKM 11.3) and 25 other tissues See more
Orthologs
NEW
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Genomic context

See ZBTB1 in Genome Data Viewer
Location:
14q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64503716..64533693)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58711422..58741460)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64971488..65000411)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:64858021-64858754 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:64858755-64859488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:64859797-64860574 Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene Sharpr-MPRA regulatory region 9441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5833 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5834 Neighboring gene A-kinase anchoring protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8535 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64970928-64971598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5837 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5839 Neighboring gene heat shock protein family A (Hsp70) member 2 Neighboring gene protein phosphatase 1 regulatory subunit 36 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65039864-65040400

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0997

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell mediated immunity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of natural killer cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of pro-T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in translesion synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123329.2NP_001116801.1  zinc finger and BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001116801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AW965994, BC050719, BM975910, BX248777
    Consensus CDS
    CCDS45126.1
    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
    UniProtKB/TrEMBL
    Q5UW39
    Related
    ENSP00000506911.1, ENST00000683701.1
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
  2. NM_014950.3NP_055765.2  zinc finger and BTB domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_055765.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' coding region and 3' UTR, compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB023214, AL049869, BX248777, CN362091
    Consensus CDS
    CCDS32097.1
    UniProtKB/TrEMBL
    Q5UW39
    Related
    ENSP00000351587.3, ENST00000358738.3
    Conserved Domains (2) summary
    sd00017
    Location:536574
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    64503716..64533693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431111.1XP_047287067.1  zinc finger and BTB domain-containing protein 1 isoform X2

  2. XM_047431093.1XP_047287049.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  3. XM_047431095.1XP_047287051.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  4. XM_047431098.1XP_047287054.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  5. XM_047431091.1XP_047287047.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  6. XM_047431106.1XP_047287062.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  7. XM_047431100.1XP_047287056.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  8. XM_047431107.1XP_047287063.1  zinc finger and BTB domain-containing protein 1 isoform X2

  9. XM_047431092.1XP_047287048.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  10. XM_047431088.1XP_047287044.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  11. XM_047431102.1XP_047287058.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
    Related
    ENSP00000451000.1, ENST00000554015.5
  12. XM_047431086.1XP_047287042.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  13. XM_047431096.1XP_047287052.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  14. XM_047431090.1XP_047287046.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  15. XM_047431104.1XP_047287060.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  16. XM_047431097.1XP_047287053.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  17. XM_047431087.1XP_047287043.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  18. XM_047431108.1XP_047287064.1  zinc finger and BTB domain-containing protein 1 isoform X2

  19. XM_047431110.1XP_047287066.1  zinc finger and BTB domain-containing protein 1 isoform X2

  20. XM_047431103.1XP_047287059.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  21. XM_005267410.2XP_005267467.1  zinc finger and BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005267467.1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
    UniProtKB/TrEMBL
    Q5UW39
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
  22. XM_017021095.2XP_016876584.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
    UniProtKB/TrEMBL
    Q5UW39
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
  23. XM_011536566.3XP_011534868.1  zinc finger and BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011534868.1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
    UniProtKB/TrEMBL
    Q5UW39
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
  24. XM_047431094.1XP_047287050.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  25. XM_047431105.1XP_047287061.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  26. XM_047431101.1XP_047287057.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    58711422..58741460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375589.1XP_054231564.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  2. XM_054375602.1XP_054231577.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  3. XM_054375591.1XP_054231566.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  4. XM_054375587.1XP_054231562.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  5. XM_054375595.1XP_054231570.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  6. XM_054375586.1XP_054231561.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  7. XM_054375600.1XP_054231575.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  8. XM_054375593.1XP_054231568.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  9. XM_054375594.1XP_054231569.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  10. XM_054375607.1XP_054231582.1  zinc finger and BTB domain-containing protein 1 isoform X2

  11. XM_054375582.1XP_054231557.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  12. XM_054375584.1XP_054231559.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  13. XM_054375581.1XP_054231556.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  14. XM_054375604.1XP_054231579.1  zinc finger and BTB domain-containing protein 1 isoform X2

  15. XM_054375588.1XP_054231563.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  16. XM_054375592.1XP_054231567.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  17. XM_054375598.1XP_054231573.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  18. XM_054375599.1XP_054231574.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  19. XM_054375605.1XP_054231580.1  zinc finger and BTB domain-containing protein 1 isoform X2

  20. XM_054375603.1XP_054231578.1  zinc finger and BTB domain-containing protein 1 isoform X2

  21. XM_054375606.1XP_054231581.1  zinc finger and BTB domain-containing protein 1 isoform X2

  22. XM_054375583.1XP_054231558.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  23. XM_054375597.1XP_054231572.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  24. XM_054375585.1XP_054231560.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  25. XM_054375590.1XP_054231565.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  26. XM_054375601.1XP_054231576.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1
  27. XM_054375596.1XP_054231571.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6S8, Q86SW8, Q9Y2K1