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Zbtb10 zinc finger and BTB domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 229055, updated on 28-Oct-2024

Summary

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Official Symbol
Zbtb10provided by MGI
Official Full Name
zinc finger and BTB domain containing 10provided by MGI
Primary source
MGI:MGI:2139883
See related
Ensembl:ENSMUSG00000069114 AllianceGenome:MGI:2139883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RINZF; 4832414A18
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and telomeric DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZBTB10 (zinc finger and BTB domain containing 10). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in placenta adult (RPKM 9.7), CNS E11.5 (RPKM 3.6) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb10 in Genome Data Viewer
Location:
3 A1; 3 2.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (9315627..9350393)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (9250567..9285333)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33018 Neighboring gene STARR-seq mESC enhancer starr_06898 Neighboring gene predicted gene, 52635 Neighboring gene STARR-seq mESC enhancer starr_06899 Neighboring gene STARR-positive B cell enhancer mm9_chr3:9249729-9250030 Neighboring gene STARR-seq mESC enhancer starr_06901 Neighboring gene predicted gene, 41997 Neighboring gene STARR-seq mESC enhancer starr_06902 Neighboring gene VISTA enhancer mm551 Neighboring gene RIKEN cDNA C030034L19 gene Neighboring gene STARR-seq mESC enhancer starr_06904 Neighboring gene zinc finger protein 704

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177660.3 → NP_808328.2  zinc finger and BTB domain-containing protein 10

    Status: VALIDATED

    Source sequence(s)
    AC126450, AK048280, AK048365, AK083443, BM899487, BY718125, CB525445, CJ114435, CK341409
    Consensus CDS
    CCDS50861.1
    UniProtKB/TrEMBL
    E9Q8X5
    Related
    ENSMUSP00000119386.2, ENSMUST00000155203.2
    Conserved Domains (6) summary
    smart00225
    Location:358 → 454
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00597
    Location:242 → 309
    ZnF_TTF; zinc finger in transposases and transcription factors
    sd00017
    Location:716 → 736
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:347 → 453
    BTB; BTB/POZ domain
    pfam13465
    Location:729 → 753
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:714 → 738
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    9315627..9350393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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