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Qrfpr pyroglutamylated RFamide peptide receptor [ Mus musculus (house mouse) ]

Gene ID: 229214, updated on 28-Oct-2024

Summary

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Official Symbol
Qrfprprovided by MGI
Official Full Name
pyroglutamylated RFamide peptide receptorprovided by MGI
Primary source
MGI:MGI:2677633
See related
Ensembl:ENSMUSG00000058400 AllianceGenome:MGI:2677633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AQ27; Gpr103; SP9155
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Located in non-motile cilium. Is expressed in ventral pallium. Used to study bone structure disease. Orthologous to human QRFPR (pyroglutamylated RFamide peptide receptor). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in cortex adult (RPKM 1.2), frontal lobe adult (RPKM 0.8) and 8 other tissues See more
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Genomic context

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See Qrfpr in Genome Data Viewer
Location:
3 B; 3 17.41 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (36233575..36276462, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (36179426..36222275, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54173 Neighboring gene STARR-positive B cell enhancer ABC_E10177 Neighboring gene zinc finger protein 267 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 11 Neighboring gene STARR-seq mESC enhancer starr_07420 Neighboring gene STARR-seq mESC enhancer starr_07421 Neighboring gene STARR-seq mESC enhancer starr_07422 Neighboring gene predicted gene, 42208 Neighboring gene predicted gene, 42209 Neighboring gene hemopexin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Anxiolytic effect of the GPR103 receptor agonist peptide P550 (homolog of neuropeptide 26RFa) in mice. Involvement of neurotransmitters. Palotai M, et al. Peptides, 2016 Aug. PMID 27224020
  2. The G-protein-coupled receptor GPR103 regulates bone formation. Baribault H, et al. Mol Cell Biol, 2006 Jan. PMID 16382160, Free PMC Article
  3. The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors. Cook C, et al. PLoS One, 2022. PMID 36251705, Free PMC Article
  4. Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development. Patel SK, et al. Int J Biol Macromol, 2019 Feb 1. PMID 30219516
  5. GPR103b functions in the peripheral regulation of adipogenesis. Mulumba M, et al. Mol Endocrinol, 2010 Aug. PMID 20534693, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
    Title: The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
  2. Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development
    Title: Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development.
  3. we treated mice with the synthetic GPR103 receptor agonist peptide P550 and the anxious behavior was investigated using an elevated plus-maze test.
    Title: Anxiolytic effect of the GPR103 receptor agonist peptide P550 (homolog of neuropeptide 26RFa) in mice. Involvement of neurotransmitters.
  4. Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.
    Title: GPR103b functions in the peripheral regulation of adipogenesis.
  5. Osteopenia in GPR103-/- mice may be mediated directly by the loss of GPR103 expression in bone.
    Title: The G-protein-coupled receptor GPR103 regulates bone formation.
  6. QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome
    Title: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
  7. characterization and tissue distribution of SP9155 (GPR103) ligand [GPR103/SP9155]
    Title: Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyroglutamylated RF-amide peptide receptor
Names
G protein-coupled receptor 103
QRFP receptor
orexigenic neuropeptide QRFP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198192.3 → NP_937835.1  pyroglutamylated RF-amide peptide receptor

    See identical proteins and their annotated locations for NP_937835.1

    Status: VALIDATED

    Source sequence(s)
    AC102844
    Consensus CDS
    CCDS17311.1
    UniProtKB/Swiss-Prot
    P83861
    UniProtKB/TrEMBL
    Q3UQ27, Q4VA00
    Related
    ENSMUSP00000088768.6, ENSMUST00000091227.9
    Conserved Domains (1) summary
    cd15205
    Location:46 → 343
    7tmA_QRFPR; pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    36233575..36276462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83861.1 GenPept UniProtKB/Swiss-Prot:P83861

Gene LinkOut

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