KIN Kin17 DNA and RNA binding protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: KINprovided by HGNC
Official Full Name: Kin17 DNA and RNA binding proteinprovided by HGNC
Primary source: HGNC:HGNC:6327
See related: Ensembl:ENSG00000151657 MIM:601720; AllianceGenome:HGNC:6327
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BTCD; Rts2; KIN17
Summary: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression: Ubiquitous expression in endometrium (RPKM 1.8), thyroid (RPKM 1.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p14

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (7750962..7787993, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (7751725..7788763, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (7792925..7829956, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[1]H, [15]N, and [13]C resonance assignments of the SH3-like tandem domain of human KIN protein.
Title: (1)H, (15)N, and (13)C resonance assignments of the SH3-like tandem domain of human KIN protein.
KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma.
Title: KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma.
KIN17 promotes cell migration and invasion through stimulating the TGF-beta/Smad2 pathway in hepatocellular carcinoma.
Title: KIN17 promotes cell migration and invasion through stimulating the TGF-β/Smad2 pathway in hepatocellular carcinoma.
KIN17 promotes tumor metastasis by activating EMT signaling in luminal-A breast cancer.
Title: KIN17 promotes tumor metastasis by activating EMT signaling in luminal-A breast cancer.
Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein.
Title: Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein.
Kin17 facilitates thyroid cancer cell proliferation, migration, and invasion by activating p38 MAPK signaling pathway.
Title: Kin17 facilitates thyroid cancer cell proliferation, migration, and invasion by activating p38 MAPK signaling pathway.
characterization and molecular phylogeny of human KIN protein
Title: Biophysical characterization and molecular phylogeny of human KIN protein.
Findings demonstrate that kin17 is closely related to the cell proliferation and invasion of cervical cancer.
Title: Elevated Expression of Kin17 in Cervical Cancer and Its Association With Cancer Cell Proliferation and Invasion.
overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype.
Title: KIN enhances stem cell-like properties to promote chemoresistance in colorectal carcinoma.
Trimethylated at Lys-135 by METTL22
Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S277 (e-PCR)
- UniSTS:148000

D7S2067E (e-PCR)
- UniSTS:151120

D22S1584 (e-PCR)
- UniSTS:473695

KIN_9291 (e-PCR)
- UniSTS:468073

D1S1425 (e-PCR)
- UniSTS:149621

WI-17908 (e-PCR)
- UniSTS:20341

G32796 (e-PCR)
- UniSTS:117375

RH118500 (e-PCR)
- UniSTS:137895

GDB:313783 (e-PCR)
- UniSTS:13512

ECD04345 (e-PCR)
- UniSTS:285422

L17791 (e-PCR)
- UniSTS:42740

A009S02 (e-PCR)
- UniSTS:56571

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA/RNA-binding protein KIN17

Names: KIN, antigenic determinant of recA protein homolog; binding to curved DNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012311.4 → NP_036443.1 DNA/RNA-binding protein KIN17

See identical proteins and their annotated locations for NP_036443.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.

Source sequence(s)

AA768850, AJ005273, AK301789, AL158044

Consensus CDS

CCDS7080.1

UniProtKB/Swiss-Prot

B4DX32, O60870

Related

ENSP00000368881.3, ENST00000379562.9

Conserved Domains (4) summary

smart00451
Location:25 → 54

ZnF_U1; U1-like zinc finger

cd13155
Location:339 → 392

KOW_KIN17; KOW_Kin17 is a RNA-binding motif

pfam10357
Location:55 → 177

Kin17_mid; Domain of Kin17 curved DNA-binding protein

pfam18131
Location:276 → 328

KN17_SH3; KN17 SH3-like C-terminal domain

RNA

NR_045609.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses alternate exon structure at its 3' end, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA768850, AK301789, AL158044

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

7750962..7787993 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006717435.5 → XP_006717498.1 DNA/RNA-binding protein KIN17 isoform X2

UniProtKB/TrEMBL

B7Z421

Conserved Domains (2) summary

pfam10357
Location:1 → 71

Kin17_mid; Domain of Kin17 curved DNA-binding protein

cl00354
Location:233 → 267

KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)
XM_006717434.5 → XP_006717497.1 DNA/RNA-binding protein KIN17 isoform X1

See identical proteins and their annotated locations for XP_006717497.1

Conserved Domains (2) summary

pfam10357
Location:55 → 177

Kin17_mid; Domain of Kin17 curved DNA-binding protein

cl00354
Location:339 → 373

KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)

RNA

XR_930485.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

7751725..7788763 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054365236.1 → XP_054221211.1 DNA/RNA-binding protein KIN17 isoform X1
XM_054365237.1 → XP_054221212.1 DNA/RNA-binding protein KIN17 isoform X2

RNA

XR_008488183.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_045610.1: Suppressed sequence

Description

NR_045610.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain intronic sequence at its 3'' end.