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Tmem131l transmembrane 131 like [ Mus musculus (house mouse) ]

Gene ID: 229473, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem131lprovided by MGI
Official Full Name
transmembrane 131 likeprovided by MGI
Primary source
MGI:MGI:2443399
See related
Ensembl:ENSMUSG00000033767 AllianceGenome:MGI:2443399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0922; mKIAA0922; D930015E06Rik
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TMEM131L (transmembrane 131 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 30.1), whole brain E14.5 (RPKM 27.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem131l in Genome Data Viewer
Location:
3 F1; 3 37.42 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (83804955..83947497, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83898205..84040190, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 175 pseudogene Neighboring gene toll-like receptor 2 Neighboring gene STARR-seq mESC enhancer starr_08062 Neighboring gene STARR-seq mESC enhancer starr_08063 Neighboring gene STARR-seq mESC enhancer starr_08065 Neighboring gene STARR-positive B cell enhancer ABC_E518 Neighboring gene STARR-positive B cell enhancer ABC_E4548 Neighboring gene predicted gene, 30352 Neighboring gene predicted gene, 30458

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential gene expression during terminal erythroid differentiation. Koury S, et al. Genomics, 2007 Nov. PMID 17764892, Free PMC Article
  2. Regulatory pathway analysis by high-throughput in situ hybridization. Visel A, et al. PLoS Genet, 2007 Oct. PMID 17953485, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of immature T cell proliferation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transmembrane protein 131-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399526.1 → NP_001386455.1  transmembrane protein 131-like isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102289, AC133160, AC154875

  2. NM_172681.5 → NP_766269.3  transmembrane protein 131-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_766269.3

    Status: VALIDATED

    Source sequence(s)
    AC102289, AC133160, AC154875
    Consensus CDS
    CCDS38463.1
    UniProtKB/Swiss-Prot
    Q3U3D7, Q6P5E2, Q6PHM5, Q6ZQ24, Q8C2B9, Q8K2U7, Q8R3Y2, Q8R580
    Related
    ENSMUSP00000141438.2, ENSMUST00000191758.6
    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    83804955..83947497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163039.1 → XP_036018932.1  transmembrane protein 131-like isoform X7

    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  2. XM_006501326.4 → XP_006501389.1  transmembrane protein 131-like isoform X5

    UniProtKB/TrEMBL
    A0A0B4J1F5
    Related
    ENSMUSP00000049808.9, ENSMUST00000052342.9
    Conserved Domains (2) summary
    pfam06070
    Location:1170 → 1520
    Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  3. XM_036163038.1 → XP_036018931.1  transmembrane protein 131-like isoform X3

    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  4. XM_006501323.3 → XP_006501386.1  transmembrane protein 131-like isoform X1

    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  5. XM_006501327.3 → XP_006501390.1  transmembrane protein 131-like isoform X6

    Related
    ENSMUSP00000141607.2, ENSMUST00000192095.6
    Conserved Domains (2) summary
    pfam06070
    Location:1189 → 1520
    Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  6. XM_006501325.2 → XP_006501388.1  transmembrane protein 131-like isoform X4

    UniProtKB/Swiss-Prot
    Q3U3D7
    Conserved Domains (2) summary
    pfam06070
    Location:1189 → 1521
    Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  7. XM_006501324.3 → XP_006501387.1  transmembrane protein 131-like isoform X2

    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U3D7.1 GenPept UniProtKB/Swiss-Prot:Q3U3D7

Gene LinkOut

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