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Fhdc1 FH2 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 229474, updated on 18-Sep-2024

Summary

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Official Symbol
Fhdc1provided by MGI
Official Full Name
FH2 domain containing 1provided by MGI
Primary source
MGI:MGI:2684972
See related
Ensembl:ENSMUSG00000041842 AllianceGenome:MGI:2684972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm126; 6330505N24Rik
Summary
Enables actin binding activity and microtubule binding activity. Involved in Golgi ribbon formation and cilium assembly. Located in Golgi apparatus and cytoplasmic microtubule. Is expressed in alimentary system; brain; heart; lung; and testis. Orthologous to human FHDC1 (FH2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 8.5), liver E14.5 (RPKM 7.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Fhdc1 in Genome Data Viewer
Location:
3 F1; 3 37.67 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84349503..84387746, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84442191..84480439, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 2 Neighboring gene nuclear encoded tRNA glycine 9 (anticodon GCC) Neighboring gene predicted gene, 40078 Neighboring gene STARR-positive B cell enhancer ABC_E3441 Neighboring gene RIKEN cDNA 4930565D16 gene Neighboring gene STARR-seq mESC enhancer starr_08085 Neighboring gene ADP-ribosylation factor interacting protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:84346416-84346716 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 35410

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Actin- and microtubule-dependent regulation of Golgi morphology by FHDC1. Copeland SJ, et al. Mol Biol Cell, 2016 Jan 15. PMID 26564798, Free PMC Article
  2. INF1 is a novel microtubule-associated formin. Young KG, et al. Mol Biol Cell, 2008 Dec. PMID 18815276, Free PMC Article
  3. Actin-dependent regulation of cilia length by the inverted formin FHDC1. Copeland SJ, et al. Mol Biol Cell, 2018 Jul 1. PMID 29742020, Free PMC Article
  4. Expression of multiple formins in adult tissues and during developmental stages of mouse brain. Dutta P, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26272686
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FHDC1 plays a role in coordinating cytoskeletal dynamics during normal cilia assembly.
    Title: Actin-dependent regulation of cilia length by the inverted formin FHDC1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FH2 domain-containing protein 1
Names
inverted formin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033301.4 → NP_001028473.2  FH2 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001028473.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC102140
    Consensus CDS
    CCDS17438.1
    UniProtKB/Swiss-Prot
    B9EHC4, Q3ULZ2, Q69ZC2, Q8C0A0
    Related
    ENSMUSP00000103317.2, ENSMUST00000107689.7
    Conserved Domains (3) summary
    PHA03247
    Location:823 → 1064
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:524 → 981
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam02181
    Location:94 → 458
    FH2; Formin Homology 2 Domain

  2. NM_001205355.1 → NP_001192284.1  FH2 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001192284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC102140
    Consensus CDS
    CCDS17438.1
    UniProtKB/Swiss-Prot
    B9EHC4, Q3ULZ2, Q69ZC2, Q8C0A0
    Related
    ENSMUSP00000088525.2, ENSMUST00000091002.8
    Conserved Domains (3) summary
    PHA03247
    Location:823 → 1064
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:524 → 981
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam02181
    Location:94 → 458
    FH2; Formin Homology 2 Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    84349503..84387746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501328.5 → XP_006501391.1  FH2 domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006501391.1

    UniProtKB/Swiss-Prot
    B9EHC4, Q3ULZ2, Q69ZC2, Q8C0A0
    Conserved Domains (3) summary
    PHA03247
    Location:823 → 1064
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:524 → 981
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam02181
    Location:94 → 458
    FH2; Formin Homology 2 Domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ULZ2.3 GenPept UniProtKB/Swiss-Prot:Q3ULZ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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