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Cym chymosin [ Mus musculus (house mouse) ]

Gene ID: 229697, updated on 28-Oct-2024

Summary

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Official Symbol
Cymprovided by MGI
Official Full Name
chymosinprovided by MGI
Primary source
MGI:MGI:2684977
See related
Ensembl:ENSMUSG00000046213 AllianceGenome:MGI:2684977
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm131
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in stomach fundus epithelium. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in stomach adult (RPKM 16.9), duodenum adult (RPKM 11.6) and 2 other tissues See more
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Genomic context

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See Cym in Genome Data Viewer
Location:
3 F2.3; 3 46.68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107118611..107129048, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107211295..107221732, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38712 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 2 Neighboring gene STARR-seq mESC enhancer starr_08660 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 10 Neighboring gene RIKEN cDNA A630076J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6103 Neighboring gene prokineticin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:107081789-107082089 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors. Sayols S, et al. Development, 2020 Sep 15. PMID 32878924
  2. Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. Chang I, et al. J Clin Invest, 2013 Jun. PMID 23676500, Free PMC Article
  3. Id2 Determines Intestinal Identity through Repression of the Foregut Transcription Factor Irx5. Mori K, et al. Mol Cell Biol, 2018 May 1. PMID 29463648, Free PMC Article
  4. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
embryonic pepsinogen
NP_001104613.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111143.1 → NP_001104613.1  embryonic pepsinogen precursor

    See identical proteins and their annotated locations for NP_001104613.1

    Status: PROVISIONAL

    Source sequence(s)
    AC132405
    Consensus CDS
    CCDS51041.1
    UniProtKB/TrEMBL
    B7ZWD6
    Related
    ENSMUSP00000029504.9, ENSMUST00000029504.9
    Conserved Domains (3) summary
    pfam00026
    Location:73 → 378
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:19 → 44
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:64 → 377
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107118611..107129048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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