Slc25a24 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a24provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24provided by MGI
Primary source: MGI:MGI:1917160
See related: Ensembl:ENSMUSG00000040322 AllianceGenome:MGI:1917160
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCaMC-1; 2610016M12Rik
Summary: Predicted to enable ADP:phosphate antiporter activity; ATP:phosphate antiporter activity; and calcium ion binding activity. Predicted to be involved in cellular response to calcium ion; cellular response to oxidative stress; and purine ribonucleotide transport. Located in mitochondrion. Is expressed in cartilage; genitourinary system; and trachea. Orthologous to human SLC25A24 (solute carrier family 25 member 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in colon adult (RPKM 19.5), large intestine adult (RPKM 18.1) and 21 other tissues See more
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Genomic context

Location:: 3 F3; 3 48.13 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (109030465..109075725)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (109123149..109168409)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arginine-methylated c-Myc affects mitochondrial mitophagy in mouse acute kidney injury via Slc25a24.
Title: Arginine-methylated c-Myc affects mitochondrial mitophagy in mouse acute kidney injury via Slc25a24.
Genetic analyses in human and mouse models revealed the importance of SLC25A24/Slc25a24 in the regulation of body fat mass and adipogenesis.
Title: SLC25A24 as a novel susceptibility gene for low fat mass in humans and mice.
SCaMC-1 exerts a negative feedback control between cellular Ca(2+) overload and mPT-dependent cell death, suggesting that the carrier might represent a novel target for cancer therapy.
Title: SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH26333 (e-PCR)
- UniSTS:83625

Slc25a24 (e-PCR), detects polymorphism
- UniSTS:527544

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP:phosphate antiporter activity	ISO Inferred from Sequence Orthology more info
enables ADP:phosphate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP:phosphate antiporter activity	ISO Inferred from Sequence Orthology more info
enables ATP:phosphate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables adenine nucleotide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ADP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ADP transport	IEA Inferred from Electronic Annotation more info
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenine nucleotide transport	ISO Inferred from Sequence Orthology more info
involved_in adenine nucleotide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ATP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ATP transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial adenyl nucleotide antiporter SLC25A24

Names: calcium-binding mitochondrial carrier protein SCaMC-1; small calcium-binding mitochondrial carrier protein 1; solute carrier family 25 member 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172685.3 → NP_766273.1 mitochondrial adenyl nucleotide antiporter SLC25A24

See identical proteins and their annotated locations for NP_766273.1

Status: PROVISIONAL

Source sequence(s)

AL671921, AL845310

Consensus CDS

CCDS17772.1

UniProtKB/Swiss-Prot

Q3TCQ2, Q3THY3, Q7TPC2, Q8BMD8

Related

ENSMUSP00000029477.7, ENSMUST00000029477.11

Conserved Domains (4) summary

cd00051
Location:28 → 85

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

PTZ00169
Location:199 → 470

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:194 → 281

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:25 → 84

EF-hand_7; EF-hand domain pair