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Arhgef39 Rho guanine nucleotide exchange factor 39 [ Mus musculus (house mouse) ]

Gene ID: 230098, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgef39provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 39provided by MGI
Primary source
MGI:MGI:3036286
See related
Ensembl:ENSMUSG00000051517 AllianceGenome:MGI:3036286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130306D19Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of cell migration. Predicted to be active in plasma membrane. Is expressed in cerebral cortex ventricular layer. Orthologous to human ARHGEF39 (Rho guanine nucleotide exchange factor 39). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in large intestine adult (RPKM 17.9), colon adult (RPKM 15.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgef39 in Genome Data Viewer
Location:
4 A5; 4 23.04 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43496139..43508747, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43496139..43508747, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E834 Neighboring gene coiled-coil domain containing 107 Neighboring gene RNA component of mitochondrial RNAase P Neighboring gene carbonic anhydrase 9 Neighboring gene STARR-positive B cell enhancer ABC_E9584 Neighboring gene tropomyosin 2, beta Neighboring gene talin 1 Neighboring gene STARR-seq mESC enhancer starr_10056

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
  2. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 39
Names
Rho guanine nucleotide exchange factor (GEF) 39
vav-like protein C9orf100 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013377.3 → NP_001013395.2  rho guanine nucleotide exchange factor 39

    See identical proteins and their annotated locations for NP_001013395.2

    Status: VALIDATED

    Source sequence(s)
    AL732506, BC080700, BY110275, BY210170, CA326178
    Consensus CDS
    CCDS18098.1
    UniProtKB/Swiss-Prot
    A2AIN0, Q3TQV6, Q66JY6
    Related
    ENSMUSP00000055293.7, ENSMUST00000054538.13
    Conserved Domains (4) summary
    smart00233
    Location:228 → 331
    PH; Pleckstrin homology domain
    pfam00169
    Location:230 → 331
    PH; PH domain
    pfam00621
    Location:27 → 196
    RhoGEF; RhoGEF domain
    cl17171
    Location:199 → 255
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43496139..43508747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253417.1 → XP_030109277.1  rho guanine nucleotide exchange factor 39 isoform X1

    Conserved Domains (3) summary
    smart00233
    Location:228 → 331
    PH; Pleckstrin homology domain
    pfam00621
    Location:27 → 195
    RhoGEF; RhoGEF domain
    cl17171
    Location:199 → 255
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66JY6.2 GenPept UniProtKB/Swiss-Prot:Q66JY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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