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Acnat1 acyl-coenzyme A amino acid N-acyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 230161, updated on 2-Nov-2024

Summary

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Official Symbol
Acnat1provided by MGI
Official Full Name
acyl-coenzyme A amino acid N-acyltransferase 1provided by MGI
Primary source
MGI:MGI:2140197
See related
Ensembl:ENSMUSG00000070985 AllianceGenome:MGI:2140197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables N-acyltransferase activity. Involved in fatty acid metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 10.5), kidney adult (RPKM 8.0) and 6 other tissues See more
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Genomic context

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See Acnat1 in Genome Data Viewer
Location:
4 B1; 4 26.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49443532..49481315, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49443532..49481315, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene acyl-coenzyme A amino acid N-acyltransferase 2 Neighboring gene predicted gene 12451 Neighboring gene predicted gene 12452 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_10182 Neighboring gene STARR-seq mESC enhancer starr_10183 Neighboring gene STARR-seq mESC enhancer starr_10184 Neighboring gene predicted gene, 26424 Neighboring gene predicted gene, 33009 Neighboring gene predicted gene, 32894 Neighboring gene bile acid-Coenzyme A: amino acid N-acyltransferase Neighboring gene predicted gene, 52736

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids. Reilly SJ, et al. FASEB J, 2007 Jan. PMID 17116739
  2. Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism. Hunt MC, et al. Prog Lipid Res, 2008 Nov. PMID 18538142
  3. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article
  4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiolester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acyl-coenzyme A amino acid N-acyltransferase 1
NP_001158037.1
XP_006537902.1
XP_006537903.1
XP_006537905.1
XP_006537906.1
XP_011248302.1
XP_011248304.1
XP_011248305.1
XP_011248306.1
XP_011248307.1
XP_030109278.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164565.1 → NP_001158037.1  acyl-coenzyme A amino acid N-acyltransferase 1

    See identical proteins and their annotated locations for NP_001158037.1

    Status: VALIDATED

    Source sequence(s)
    AL772310
    Consensus CDS
    CCDS51174.1
    UniProtKB/Swiss-Prot
    A2AKK4, A2AKK5, Q0QBA1
    Related
    ENSMUSP00000092702.3, ENSMUST00000095086.3
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 411
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:15 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    49443532..49481315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250005.3 → XP_011248307.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_011248307.1

    UniProtKB/Swiss-Prot
    A2AKK4, A2AKK5, Q0QBA1
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 411
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:15 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  2. XM_011250004.3 → XP_011248306.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_011248306.1

    UniProtKB/Swiss-Prot
    A2AKK4, A2AKK5, Q0QBA1
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 411
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:15 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  3. XM_011250002.3 → XP_011248304.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_011248304.1

    UniProtKB/Swiss-Prot
    A2AKK4, A2AKK5, Q0QBA1
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 411
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:15 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  4. XM_006537842.4 → XP_006537905.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_006537905.1

    UniProtKB/Swiss-Prot
    A2AKK4, A2AKK5, Q0QBA1
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 411
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:15 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  5. XM_006537843.4 → XP_006537906.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_006537906.1

    UniProtKB/Swiss-Prot
    A2AKK4, A2AKK5, Q0QBA1
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 411
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:15 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  6. XM_006537840.4 → XP_006537903.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006537903.1

    Conserved Domains (2) summary
    pfam08840
    Location:221 → 425
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:29 → 154
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  7. XM_006537839.4 → XP_006537902.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006537902.1

    Conserved Domains (2) summary
    pfam08840
    Location:221 → 425
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:29 → 154
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  8. XM_011250003.3 → XP_011248305.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_011248305.1

    UniProtKB/Swiss-Prot
    A2AKK4, A2AKK5, Q0QBA1
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 411
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:15 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  9. XM_011250000.3 → XP_011248302.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011248302.1

    Conserved Domains (2) summary
    pfam08840
    Location:221 → 425
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:29 → 154
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

  10. XM_030253418.1 → XP_030109278.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A2AKK4, A2AKK5, Q0QBA1
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 411
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:15 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AKK5.1 GenPept UniProtKB/Swiss-Prot:A2AKK5

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