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Tmem268 transmembrane protein 268 [ Mus musculus (house mouse) ]

Gene ID: 230279, updated on 11-Nov-2024

Summary

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Official Symbol
Tmem268provided by MGI
Official Full Name
transmembrane protein 268provided by MGI
Primary source
MGI:MGI:1913920
See related
Ensembl:ENSMUSG00000045917 AllianceGenome:MGI:1913920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bM230C2.2; 6330416G13Rik
Summary
Predicted to be located in plasma membrane. Orthologous to human TMEM268 (transmembrane protein 268). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E18 (RPKM 6.3), colon adult (RPKM 4.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem268 in Genome Data Viewer
Location:
4 B3; 4 34.02 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63472410..63504594)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63554595..63586357)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10437 Neighboring gene whirlin Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63141720-63141921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63150850-63151053 Neighboring gene STARR-positive B cell enhancer mm9_chr4:63205604-63205905 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 Neighboring gene predicted gene, 38592 Neighboring gene predicted gene, 24448 Neighboring gene STARR-positive B cell enhancer mm9_chr4:63263195-63263495 Neighboring gene testis expressed 53 Neighboring gene testis expressed 48

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling. Duan M, et al. EMBO Rep, 2024 Jun. PMID 38730209, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling.
    Title: Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC31101

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 268
Names
transmembrane protein C9orf91 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356354.1 → NP_001343283.1  transmembrane protein 268

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AI593215, AK030466, AK031016, AK078066, BY067212, CJ046188
    Consensus CDS
    CCDS18261.1
    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Related
    ENSMUSP00000076891.5, ENSMUST00000077709.11
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

  2. NM_001356355.1 → NP_001343284.1  transmembrane protein 268

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AI593215, AK030466, AK031016, AK078066, AL691484, BY067212, CJ046188
    Consensus CDS
    CCDS18261.1
    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

  3. NM_144905.4 → NP_659154.2  transmembrane protein 268

    See identical proteins and their annotated locations for NP_659154.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AI593215, AK031016, AK078066, AL691484, BY171339
    Consensus CDS
    CCDS18261.1
    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Related
    ENSMUSP00000079211.3, ENSMUST00000080336.4
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63472410..63504594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537868.5 → XP_006537931.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_006537931.1

    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

  2. XM_006537867.4 → XP_006537930.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_006537930.1

    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

  3. XM_006537871.4 → XP_006537934.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_006537934.1

    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

  4. XM_006537870.4 → XP_006537933.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_006537933.1

    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

  5. XM_006537869.1 → XP_006537932.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_006537932.1

    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

  6. XM_006537872.4 → XP_006537935.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_006537935.1

    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

  7. XM_006537873.4 → XP_006537936.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_006537936.1

    UniProtKB/Swiss-Prot
    Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
    Conserved Domains (1) summary
    pfam14800
    Location:39 → 328
    DUF4481; Domain of unknown function (DUF4481)

RNA

  1. XR_004941862.1 RNA Sequence

  2. XR_004941863.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R239.2 GenPept UniProtKB/Swiss-Prot:Q8R239

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