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Rhbdl2 rhomboid like 2 [ Mus musculus (house mouse) ]

Gene ID: 230726, updated on 28-Oct-2024

Summary

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Official Symbol
Rhbdl2provided by MGI
Official Full Name
rhomboid like 2provided by MGI
Primary source
MGI:MGI:3608413
See related
Ensembl:ENSMUSG00000043333 AllianceGenome:MGI:3608413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RRP2; 9130416B15
Summary
Enables serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Is expressed in several structures, including adipose tissue; bone; genitourinary system; liver; and spleen. Orthologous to human RHBDL2 (rhomboid like 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in bladder adult (RPKM 4.9), colon adult (RPKM 4.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Rhbdl2 in Genome Data Viewer
Location:
4 D2.2; 4 57.42 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123681642..123723993)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123787875..123830196)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6212 Neighboring gene predicted gene, 57730 Neighboring gene akirin 1 Neighboring gene STARR-positive B cell enhancer ABC_E1654 Neighboring gene STARR-seq mESC enhancer starr_11313 Neighboring gene STARR-seq mESC enhancer starr_11314 Neighboring gene eukaryotic translation initiation factor 2C, 2 pseudogene Neighboring gene RIKEN cDNA 1700121C08 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing. Cheng TL, et al. J Invest Dermatol, 2011 Dec. PMID 21833011
  2. Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Zettl M, et al. Cell, 2011 Apr 1. PMID 21439629, Free PMC Article
  3. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
  4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  5. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
rhomboid-related protein 2
Names
rhomboid, veinlet-like 2
NP_001343374.1
NP_898986.2
XP_006503088.1
XP_036019936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356445.2 → NP_001343374.1  rhomboid-related protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683811
    Conserved Domains (1) summary
    pfam01694
    Location:51 → 203
    Rhomboid; Rhomboid family

  2. NM_183163.3 → NP_898986.2  rhomboid-related protein 2 isoform 1

    See identical proteins and their annotated locations for NP_898986.2

    Status: VALIDATED

    Source sequence(s)
    AL683811
    Consensus CDS
    CCDS38873.1
    UniProtKB/Swiss-Prot
    A2AGA4
    Related
    ENSMUSP00000054546.6, ENSMUST00000053202.12
    Conserved Domains (1) summary
    pfam01694
    Location:115 → 264
    Rhomboid; Rhomboid family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    123681642..123723993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503025.5 → XP_006503088.1  rhomboid-related protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006503088.1

    UniProtKB/Swiss-Prot
    A2AGA4
    Related
    ENSMUSP00000101810.2, ENSMUST00000106204.2
    Conserved Domains (1) summary
    pfam01694
    Location:115 → 264
    Rhomboid; Rhomboid family

  2. XM_036164043.1 → XP_036019936.1  rhomboid-related protein 2 isoform X2

    Conserved Domains (1) summary
    pfam01694
    Location:51 → 203
    Rhomboid; Rhomboid family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AGA4.1 GenPept UniProtKB/Swiss-Prot:A2AGA4

Gene LinkOut

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