Yrdc yrdC domain containing (E.coli) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Yrdcprovided by MGI
Official Full Name: yrdC domain containing (E.coli)provided by MGI
Primary source: MGI:MGI:2387201
See related: Ensembl:ENSMUSG00000028889 AllianceGenome:MGI:2387201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IRIP; ITIP
Summary: Predicted to enable L-threonylcarbamoyladenylate synthase and tRNA binding activity. Predicted to be involved in regulation of translational fidelity and tRNA threonylcarbamoyladenosine modification. Predicted to act upstream of or within negative regulation of transport. Located in membrane. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human YRDC (yrdC N6-threonylcarbamoyltransferase domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 33.7), ovary adult (RPKM 30.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.92 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (124744552..124749035)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (124850759..124855242)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-threonylcarbamoyladenylate synthase	ISO Inferred from Sequence Orthology more info
enables L-threonylcarbamoyladenylate synthase	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of translational fidelity	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA threonylcarbamoyladenosine modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA threonylcarbamoyladenosine modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: threonylcarbamoyl-AMP synthase

Names: Ischemia/reperfusion-inducible protein; mIRIP; yrdC domain-containing protein, mitochondrial

NP_705794.2

EC 2.7.7.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153566.2 → NP_705794.2 threonylcarbamoyl-AMP synthase precursor

See identical proteins and their annotated locations for NP_705794.2

Status: VALIDATED

Source sequence(s)

AI413772, AK153627

Consensus CDS

CCDS18628.2

UniProtKB/Swiss-Prot

B1ARW9, B1ARX2, Q3U5F4, Q7TSY0, Q8CII1

Related

ENSMUSP00000099688.5, ENSMUST00000102628.11

Conserved Domains (1) summary

COG0009
Location:70 → 257

SUA5; tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC [Translation, ribosomal structure and biogenesis]