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Ncmap noncompact myelin associated protein [ Mus musculus (house mouse) ]

Gene ID: 230822, updated on 28-Oct-2024

Summary

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Official Symbol
Ncmapprovided by MGI
Official Full Name
noncompact myelin associated proteinprovided by MGI
Primary source
MGI:MGI:2444888
See related
Ensembl:ENSMUSG00000043924 AllianceGenome:MGI:2444888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mp11; A330049M08Rik
Summary
Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Located in plasma membrane. Is expressed in several structures, including alimentary system; hindlimb mesenchyme; lower urinary tract; otic capsule; and skeleton. Orthologous to human NCMAP (non-compact myelin associated protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in placenta adult (RPKM 8.9), stomach adult (RPKM 7.0) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Ncmap in Genome Data Viewer
Location:
4 D3; 4 67.47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135096887..135125551, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135369576..135398240, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10266 Neighboring gene predicted gene 12984 Neighboring gene serine/arginine repetitive matrix 1 Neighboring gene STARR-positive B cell enhancer ABC_E6233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134982608-134982761 Neighboring gene regulator of calcineurin 3 Neighboring gene microRNA 700 Neighboring gene STARR-positive B cell enhancer ABC_E9603 Neighboring gene STARR-positive B cell enhancer ABC_E1286 Neighboring gene NIPA-like domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:135050361-135050662 Neighboring gene sperm tail PG rich repeat containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11. Ryu EJ, et al. J Neurosci, 2008 Jul 23. PMID 18650334, Free PMC Article
  2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of myelin sheath ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of myelin sheath ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peripheral nervous system myelin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peripheral nervous system myelin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in peripheral nervous system myelin formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Schmidt-Lanterman incisure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Schmidt-Lanterman incisure ISO
Inferred from Sequence Orthology
more info
  
located_in Schmidt-Lanterman incisure ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in paranode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in paranode region of axon ISO
Inferred from Sequence Orthology
more info
  
located_in paranode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
noncompact myelin-associated protein
Names
myelin protein of 11 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168498.1 → NP_001161970.1  noncompact myelin-associated protein isoform 1

    See identical proteins and their annotated locations for NP_001161970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 6 encode the same isoform (1).
    Source sequence(s)
    AK014757, AK039485, BB093741, BY023152
    Consensus CDS
    CCDS18784.1
    UniProtKB/Swiss-Prot
    Q99JS0
    Related
    ENSMUSP00000101483.2, ENSMUST00000105857.8

  2. NM_001168500.1 → NP_001161972.1  noncompact myelin-associated protein isoform 1

    See identical proteins and their annotated locations for NP_001161972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 6 encode the same isoform (1).
    Source sequence(s)
    AL627185
    Consensus CDS
    CCDS18784.1
    UniProtKB/Swiss-Prot
    Q99JS0
    Related
    ENSMUSP00000101485.2, ENSMUST00000105859.8

  3. NM_001243305.1 → NP_001230234.1  noncompact myelin-associated protein isoform 1

    See identical proteins and their annotated locations for NP_001230234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 6 encode the same isoform (1).
    Source sequence(s)
    AL627185
    Consensus CDS
    CCDS18784.1
    UniProtKB/Swiss-Prot
    Q99JS0
    Related
    ENSMUSP00000070780.9, ENSMUST00000064481.15

  4. NM_001243306.1 → NP_001230235.1  noncompact myelin-associated protein isoform 2

    See identical proteins and their annotated locations for NP_001230235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, contains an alternate exon and uses an upstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AL627185
    Consensus CDS
    CCDS57304.1
    UniProtKB/TrEMBL
    A2A992
    Related
    ENSMUSP00000101486.3, ENSMUST00000105860.9

  5. NM_145555.2 → NP_663530.1  noncompact myelin-associated protein isoform 1

    See identical proteins and their annotated locations for NP_663530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3, 4 and 6 encode the same isoform.
    Source sequence(s)
    AK039485, AK167453, BB093741
    Consensus CDS
    CCDS18784.1
    UniProtKB/Swiss-Prot
    Q99JS0

  6. NM_181047.1 → NP_851390.1  noncompact myelin-associated protein isoform 1

    See identical proteins and their annotated locations for NP_851390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 6 encode the same isoform (1).
    Source sequence(s)
    AK014757, AK076488, BB093741, BY023152
    Consensus CDS
    CCDS18784.1
    UniProtKB/Swiss-Prot
    Q99JS0
    Related
    ENSMUSP00000101484.2, ENSMUST00000105858.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135096887..135125551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320160.2 → XP_017175649.1  noncompact myelin-associated protein isoform X1

    UniProtKB/Swiss-Prot
    Q99JS0

  2. XM_030253469.2 → XP_030109329.1  noncompact myelin-associated protein isoform X1

    UniProtKB/Swiss-Prot
    Q99JS0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JS0.1 GenPept UniProtKB/Swiss-Prot:Q99JS0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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