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ARHGAP26 Rho GTPase activating protein 26 [ Homo sapiens (human) ]

Gene ID: 23092, updated on 3-Nov-2024

Summary

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Official Symbol
ARHGAP26provided by HGNC
Official Full Name
Rho GTPase activating protein 26provided by HGNC
Primary source
HGNC:HGNC:17073
See related
Ensembl:ENSG00000145819 MIM:605370; AllianceGenome:HGNC:17073
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRAF; GRAF1; OPHN1L; OPHN1L1
Summary
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in brain (RPKM 7.0), gall bladder (RPKM 4.5) and 24 other tissues See more
Orthologs
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Genomic context

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See ARHGAP26 in Genome Data Viewer
Location:
5q31.3
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (142770377..143229011)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (143301685..143760366)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (142149942..142608576)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene FGF1 promoter C Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:142024170-142025369 Neighboring gene Sharpr-MPRA regulatory region 3450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142039508-142040008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142040009-142040509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047003-142047511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047512-142048019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142049247-142049746 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142052360-142052880 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:142064129-142064998 Neighboring gene fibroblast growth factor 1 Neighboring gene FGF1 promoter B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142150581-142151416 Neighboring gene long intergenic non-protein coding RNA 1844 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142176991-142177492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16477 Neighboring gene ARHGAP26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142242364-142242980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142242981-142243597 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142243598-142244214 Neighboring gene Sharpr-MPRA regulatory region 7053 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142275426-142276332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:142296188-142296688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:142296689-142297189 Neighboring gene uncharacterized LOC107986457 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142362256-142363097 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142361413-142362255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23321 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:142388320-142389519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23324 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142416478-142417238 Neighboring gene uncharacterized LOC124901097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23326 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:142469655-142470246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142472885-142473646 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142473647-142474407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23327 Neighboring gene uncharacterized LOC124901098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23329 Neighboring gene ARHGAP26 intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142586801-142587300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142593978-142594526 Neighboring gene uncharacterized LOC124901099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142594527-142595075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23335 Neighboring gene uncharacterized LOC124901100 Neighboring gene nuclear receptor subfamily 3 group C member 1 Neighboring gene ribosomal protein L7 pseudogene 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Quantification of GRAF gene expression in patients with acute myeloid leukemia using EvaGreen real time quantitative PCR]. Qian Z, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2010 Jun. PMID 20533268
  2. Involvement of Rho GAP GRAF1 in maintenance of epithelial phenotype. Regev M, et al. Cell Adh Migr, 2017 Jul 4. PMID 27588930, Free PMC Article
  3. Hypoxia-induced ARHGAP26 deficiency inhibits the proliferation and migration of human ductus arteriosus smooth muscle cell through activating RhoA-ROCK-PTEN pathway. Li M, et al. J Cell Biochem, 2019 Jun. PMID 30592323
  4. Circular RNA ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cell apoptosis in gastric cancer cells. Wangxia LV, et al. Saudi J Gastroenterol, 2019 Mar-Apr. PMID 30719998, Free PMC Article
  5. High expression of GTPase regulator associated with the focal adhesion kinase (GRAF) is a favorable prognostic factor in acute myeloid leukemia. Aly RM, et al. Blood Cells Mol Dis, 2014 Dec. PMID 25088035

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
    Title: ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
  2. GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
    Title: GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
  3. CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.
    Title: CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.
  4. Missense Variants in <i>GFRA1</i> and <i>NPNT</i> Are Associated with Congenital Anomalies of the Kidney and Urinary Tract.
    Title: Missense Variants in GFRA1 and NPNT Are Associated with Congenital Anomalies of the Kidney and Urinary Tract.
  5. Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease.
    Title: Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease.
  6. The role of GTPase-activating protein ARHGAP26 in human cancers.
    Title: The role of GTPase-activating protein ARHGAP26 in human cancers.
  7. Data indicate that hypoxia-induced Rho GTPase activating protein 26 (ARHGAP26) deficiency inhibits ductus arteriosus smooth muscle cells (DASMCs) proliferation and migration through activating the RhoA-ROCK-PTEN pathway.
    Title: Hypoxia-induced ARHGAP26 deficiency inhibits the proliferation and migration of human ductus arteriosus smooth muscle cell through activating RhoA-ROCK-PTEN pathway.
  8. ARHGAP26 upregulation in SKOV3 cells significantly inhibited SMURF1 upregulation-induced cell migration and invasion. Overall, SMURF1-mediated ubiquitination of ARHGAP26 may promote invasion and migration of ovarian cancer cells via the beta-catenin pathway.
    Title: SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration.
  9. High ARHGAP26 expression is associated with adenomyosis.
    Title: RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis.
  10. This study showed that the circARHGAP26 is overexpressed and its downregulation inhibits cell proliferation and promotes cells apoptosis in GC cells.
    Title: Circular RNA ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cell apoptosis in gastric cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Juvenile myelomonocytic leukemia
MedGen: C0349639 OMIM: 607785 GeneReviews: Not available
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EBI GWAS Catalog

Description
Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42530, KIAA0621

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rho GTPase-activating protein 26
Names
GTPase regulator associated with focal adhesion kinase pp125(FAK)
oligophrenin-1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016711.2 RefSeqGene

    Range
    5008..463642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1127

mRNA and Protein(s)

  1. NM_001135608.3 → NP_001129080.1  rho GTPase-activating protein 26 isoform b

    See identical proteins and their annotated locations for NP_001129080.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC004782, AC008533, AC012630, AI888512, BC068555, BX342449
    Consensus CDS
    CCDS47297.1
    UniProtKB/TrEMBL
    A0A0S2Z536, A0A2X0SSF1
    Related
    ENSP00000495131.1, ENST00000645722.2
    Conserved Domains (4) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:704 → 759
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

  2. NM_001349547.2 → NP_001336476.1  rho GTPase-activating protein 26 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC004782, AC005348, AC008533, AC012630
    Consensus CDS
    CCDS87332.1
    UniProtKB/TrEMBL
    A0A0S2Z508, A0A2R8YGB3
    Related
    ENSP00000495827.1, ENST00000642734.1
    Conserved Domains (4) summary
    cd12064
    Location:631 → 686
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:328 → 527
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:231 → 335
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:15 → 189
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_015071.6 → NP_055886.1  rho GTPase-activating protein 26 isoform a

    See identical proteins and their annotated locations for NP_055886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC004782, AC008533, AC012630, AF141884, AI888512, BC068555, BX342449
    Consensus CDS
    CCDS4277.1
    UniProtKB/Swiss-Prot
    O75117, Q5D035, Q9BYS6, Q9BYS7, Q9UJ00, Q9UNA1
    UniProtKB/TrEMBL
    A0A2X0SSF1
    Related
    ENSP00000274498.4, ENST00000274498.9
    Conserved Domains (5) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:759 → 814
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 364
    PH; PH domain

RNA

  1. NR_146198.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004782, AC005348, AC008533, AC012630

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    142770377..143229011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268402.5 → XP_005268459.1  rho GTPase-activating protein 26 isoform X23

    See identical proteins and their annotated locations for XP_005268459.1

    UniProtKB/TrEMBL
    A0A0S2Z508
    Conserved Domains (5) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:667 → 722
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 364
    PH; PH domain

  2. XM_047416970.1 → XP_047272926.1  rho GTPase-activating protein 26 isoform X5

  3. XM_047416985.1 → XP_047272941.1  rho GTPase-activating protein 26 isoform X20

  4. XM_047416991.1 → XP_047272947.1  rho GTPase-activating protein 26 isoform X30

  5. XM_047416993.1 → XP_047272949.1  rho GTPase-activating protein 26 isoform X32

  6. XM_005268398.6 → XP_005268455.2  rho GTPase-activating protein 26 isoform X3

    UniProtKB/TrEMBL
    A0A2X0SSF1
    Conserved Domains (4) summary
    cd12064
    Location:723 → 778
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:328 → 527
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:231 → 335
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:15 → 189
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. XM_017009248.3 → XP_016864737.2  rho GTPase-activating protein 26 isoform X7

    UniProtKB/TrEMBL
    A0A2X0SSF1
    Conserved Domains (4) summary
    cd12064
    Location:678 → 733
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:328 → 527
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:231 → 335
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:15 → 189
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  8. XM_005268399.6 → XP_005268456.2  rho GTPase-activating protein 26 isoform X10

    UniProtKB/TrEMBL
    A0A2X0SSF1
    Conserved Domains (4) summary
    cd12064
    Location:668 → 723
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:328 → 527
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:231 → 335
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:15 → 189
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. XM_047416976.1 → XP_047272932.1  rho GTPase-activating protein 26 isoform X13

  10. XM_047416981.1 → XP_047272937.1  rho GTPase-activating protein 26 isoform X18

  11. XM_047416969.1 → XP_047272925.1  rho GTPase-activating protein 26 isoform X4

  12. XM_047416966.1 → XP_047272922.1  rho GTPase-activating protein 26 isoform X1

  13. XM_047416967.1 → XP_047272923.1  rho GTPase-activating protein 26 isoform X2

  14. XM_047416971.1 → XP_047272927.1  rho GTPase-activating protein 26 isoform X6

  15. XM_047416972.1 → XP_047272928.1  rho GTPase-activating protein 26 isoform X8

  16. XM_047416973.1 → XP_047272929.1  rho GTPase-activating protein 26 isoform X9

  17. XM_047416979.1 → XP_047272935.1  rho GTPase-activating protein 26 isoform X16

  18. XM_047416978.1 → XP_047272934.1  rho GTPase-activating protein 26 isoform X15

  19. XM_017009250.3 → XP_016864739.2  rho GTPase-activating protein 26 isoform X22

    UniProtKB/TrEMBL
    A0A0S2Z508
    Conserved Domains (3) summary
    cd04374
    Location:328 → 527
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:231 → 335
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:15 → 189
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  20. XM_047416986.1 → XP_047272942.1  rho GTPase-activating protein 26 isoform X21

  21. XM_047416989.1 → XP_047272945.1  rho GTPase-activating protein 26 isoform X29

  22. XM_011537611.4 → XP_011535913.2  rho GTPase-activating protein 26 isoform X28

    Conserved Domains (3) summary
    cd01249
    Location:231 → 335
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:328 → 484
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:15 → 189
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  23. XM_006714774.5 → XP_006714837.2  rho GTPase-activating protein 26 isoform X26

    Conserved Domains (3) summary
    cd01249
    Location:231 → 335
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:328 → 479
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:15 → 189
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  24. XM_011537610.4 → XP_011535912.2  rho GTPase-activating protein 26 isoform X27

    Conserved Domains (3) summary
    cd01249
    Location:231 → 335
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:328 → 479
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:15 → 189
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  25. XM_047416983.1 → XP_047272939.1  rho GTPase-activating protein 26 isoform X20

  26. XM_047416977.1 → XP_047272933.1  rho GTPase-activating protein 26 isoform X14

  27. XM_047416987.1 → XP_047272943.1  rho GTPase-activating protein 26 isoform X24

  28. XM_047416984.1 → XP_047272940.1  rho GTPase-activating protein 26 isoform X20

  29. XM_047416990.1 → XP_047272946.1  rho GTPase-activating protein 26 isoform X20

  30. XM_047416974.1 → XP_047272930.1  rho GTPase-activating protein 26 isoform X11

  31. XM_047416975.1 → XP_047272931.1  rho GTPase-activating protein 26 isoform X12

  32. XM_047416980.1 → XP_047272936.1  rho GTPase-activating protein 26 isoform X17

  33. XM_047416988.1 → XP_047272944.1  rho GTPase-activating protein 26 isoform X25

  34. XM_047416982.1 → XP_047272938.1  rho GTPase-activating protein 26 isoform X19

  35. XM_047416992.1 → XP_047272948.1  rho GTPase-activating protein 26 isoform X31

RNA

  1. XR_007058592.1 RNA Sequence

  2. XR_007058593.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    143301685..143760366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352138.1 → XP_054208113.1  rho GTPase-activating protein 26 isoform X23

  2. XM_054352119.1 → XP_054208094.1  rho GTPase-activating protein 26 isoform X5

  3. XM_054352135.1 → XP_054208110.1  rho GTPase-activating protein 26 isoform X20

  4. XM_054352146.1 → XP_054208121.1  rho GTPase-activating protein 26 isoform X30

  5. XM_054352147.1 → XP_054208122.1  rho GTPase-activating protein 26 isoform X32

  6. XM_054352118.1 → XP_054208093.1  rho GTPase-activating protein 26 isoform X33

  7. XM_054352125.1 → XP_054208100.1  rho GTPase-activating protein 26 isoform X34

  8. XM_054352116.1 → XP_054208091.1  rho GTPase-activating protein 26 isoform X3

  9. XM_054352121.1 → XP_054208096.1  rho GTPase-activating protein 26 isoform X7

  10. XM_054352124.1 → XP_054208099.1  rho GTPase-activating protein 26 isoform X10

  11. XM_054352128.1 → XP_054208103.1  rho GTPase-activating protein 26 isoform X13

  12. XM_054352133.1 → XP_054208108.1  rho GTPase-activating protein 26 isoform X18

  13. XM_054352117.1 → XP_054208092.1  rho GTPase-activating protein 26 isoform X4

  14. XM_054352114.1 → XP_054208089.1  rho GTPase-activating protein 26 isoform X1

  15. XM_054352115.1 → XP_054208090.1  rho GTPase-activating protein 26 isoform X2

  16. XM_054352120.1 → XP_054208095.1  rho GTPase-activating protein 26 isoform X6

  17. XM_054352122.1 → XP_054208097.1  rho GTPase-activating protein 26 isoform X8

  18. XM_054352123.1 → XP_054208098.1  rho GTPase-activating protein 26 isoform X9

  19. XM_054352131.1 → XP_054208106.1  rho GTPase-activating protein 26 isoform X16

  20. XM_054352137.1 → XP_054208112.1  rho GTPase-activating protein 26 isoform X22

  21. XM_054352136.1 → XP_054208111.1  rho GTPase-activating protein 26 isoform X21

  22. XM_054352144.1 → XP_054208119.1  rho GTPase-activating protein 26 isoform X29

  23. XM_054352143.1 → XP_054208118.1  rho GTPase-activating protein 26 isoform X28

  24. XM_054352141.1 → XP_054208116.1  rho GTPase-activating protein 26 isoform X26

  25. XM_054352142.1 → XP_054208117.1  rho GTPase-activating protein 26 isoform X27

  26. XM_054352129.1 → XP_054208104.1  rho GTPase-activating protein 26 isoform X14

  27. XM_054352139.1 → XP_054208114.1  rho GTPase-activating protein 26 isoform X24

  28. XM_054352145.1 → XP_054208120.1  rho GTPase-activating protein 26 isoform X20

  29. XM_054352130.1 → XP_054208105.1  rho GTPase-activating protein 26 isoform X35

  30. XM_054352126.1 → XP_054208101.1  rho GTPase-activating protein 26 isoform X11

  31. XM_054352127.1 → XP_054208102.1  rho GTPase-activating protein 26 isoform X12

  32. XM_054352132.1 → XP_054208107.1  rho GTPase-activating protein 26 isoform X17

  33. XM_054352140.1 → XP_054208115.1  rho GTPase-activating protein 26 isoform X25

  34. XM_054352134.1 → XP_054208109.1  rho GTPase-activating protein 26 isoform X19

  35. XM_054352148.1 → XP_054208123.1  rho GTPase-activating protein 26 isoform X31

RNA

  1. XR_008487101.1 RNA Sequence

  2. XR_008487102.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UNA1.1 GenPept UniProtKB/Swiss-Prot:Q9UNA1

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