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Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 [ Mus musculus (house mouse) ]

Gene ID: 230935, updated on 3-Nov-2024

Summary

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Official Symbol
Dnajc11provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C11provided by MGI
Primary source
MGI:MGI:2443386
See related
Ensembl:ENSMUSG00000039768 AllianceGenome:MGI:2443386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E030019A03Rik
Summary
Involved in cristae formation. Located in mitochondrial inner membrane. Is expressed in submandibular gland primordium. Orthologous to human DNAJC11 (DnaJ heat shock protein family (Hsp40) member C11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 12.4), placenta adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc11 in Genome Data Viewer
Location:
4 E2; 4 82.77 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152018177..152066416)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (151933720..151981959)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene predicted gene, 52710 Neighboring gene RIKEN cDNA 9230110K08 gene Neighboring gene STARR-positive B cell enhancer ABC_E30 Neighboring gene predicted gene, 42357 Neighboring gene THAP domain containing, apoptosis associated protein 3 Neighboring gene PHD finger protein 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice. Violitzi F, et al. J Proteome Res, 2019 Nov 1. PMID 31550165
  2. Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. Katoh M, et al. Int J Oncol, 2003 Oct. PMID 12964007
  3. A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice. Ioakeimidis F, et al. PLoS One, 2014. PMID 25111180, Free PMC Article
  4. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
    Title: Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
  2. a link between DNAJC11 and neuromuscular diseases
    Title: A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice.
  3. E030019A03 is the mouse ortholog of human FLJ10737, consisting of the DnaJ domain, bipartite nuclear localization signal (NLS), FADH domain, and FEMCA domain.
    Title: Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MICOS complex IEA
Inferred from Electronic Annotation
more info
  
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAM complex IEA
Inferred from Electronic Annotation
more info
  
part_of SAM complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 11
Names
DnaJ (Hsp40) homolog, subfamily C, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172704.3 → NP_766292.2  dnaJ homolog subfamily C member 11

    See identical proteins and their annotated locations for NP_766292.2

    Status: VALIDATED

    Source sequence(s)
    AK053156, BY784439, DV663024
    Consensus CDS
    CCDS18981.2
    UniProtKB/Swiss-Prot
    A2A8C9, Q5U458, Q8BP83, Q8C1Z4, Q8C6U5
    Related
    ENSMUSP00000051643.5, ENSMUST00000062904.11
    Conserved Domains (3) summary
    pfam00226
    Location:14 → 79
    DnaJ; DnaJ domain
    pfam06936
    Location:372 → 447
    Selenoprotein_S; Selenoprotein S (SelS)
    pfam11875
    Location:417 → 549
    DUF3395; Domain of unknown function (DUF3395)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152018177..152066416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253511.2 → XP_030109371.1  dnaJ homolog subfamily C member 11 isoform X1

    Conserved Domains (1) summary
    pfam11875
    Location:131 → 270
    DUF3395; Domain of unknown function (DUF3395)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U458.2 GenPept UniProtKB/Swiss-Prot:Q5U458

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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