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CLASP2 cytoplasmic linker associated protein 2 [ Homo sapiens (human) ]

Gene ID: 23122, updated on 2-Nov-2024

Summary

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Official Symbol
CLASP2provided by HGNC
Official Full Name
cytoplasmic linker associated protein 2provided by HGNC
Primary source
HGNC:HGNC:17078
See related
Ensembl:ENSG00000163539 MIM:605853; AllianceGenome:HGNC:17078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; focal adhesion; and microtubule cytoskeleton. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in brain (RPKM 43.5), adrenal (RPKM 10.5) and 22 other tissues See more
Orthologs
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Genomic context

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See CLASP2 in Genome Data Viewer
Location:
3p22.3
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (33496245..33718254, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (33497978..33719132, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (33537737..33759746, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124909363 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:33487995-33488496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:33489631-33490130 Neighboring gene NANOG hESC enhancer GRCh37_chr3:33504525-33505078 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:33508920-33510119 Neighboring gene RNA, 5S ribosomal pseudogene 128 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 10 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:33618786-33619296 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:33619297-33619807 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:33620187-33620768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19650 Neighboring gene MPRA-validated peak4600 silencer Neighboring gene MPRA-validated peak4601 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14192 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:33830741-33831638 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:33840285-33840818 Neighboring gene SDA1 domain containing 1 pseudogene 3 Neighboring gene PDCD6IP divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human CLASP2 specifically regulates microtubule catastrophe and rescue. Lawrence EJ, et al. Mol Biol Cell, 2018 May 15. PMID 29540526, Free PMC Article
  2. HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus. Mitra S, et al. J Virol, 2020 Jul 1. PMID 32376623, Free PMC Article
  3. CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation. Aher A, et al. Curr Biol, 2020 Jun 8. PMID 32359430, Free PMC Article
  4. Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. Wittmann T, et al. J Cell Biol, 2005 Jun 20. PMID 15955847, Free PMC Article
  5. CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments. Girão H, et al. J Cell Biol, 2020 Feb 3. PMID 31757788, Free PMC Article

See all (141) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLASP2 facilitates dynamic actin filament organization along the microtubule lattice.
    Title: CLASP2 facilitates dynamic actin filament organization along the microtubule lattice.
  2. CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner.
    Title: CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner.
  3. Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3beta and CK1delta regulates EB1-dependent MT dynamics in cell migration.
    Title: Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration.
  4. SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.
    Title: SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.
  5. CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation.
    Title: CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation.
  6. HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus.
    Title: HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus.
  7. Significance of CLASP2 expression in prognosis for muscle-invasive bladder cancer patients: A propensity score-based analysis.
    Title: Significance of CLASP2 expression in prognosis for muscle-invasive bladder cancer patients: A propensity score-based analysis.
  8. CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments.
    Title: CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments.
  9. microtubules grown with CLASP2 display greater variability in growth rates.
    Title: Human CLASP2 specifically regulates microtubule catastrophe and rescue.
  10. CLASP2 is involved in the epithelial-mesenchymal transition and progression of bladder urothelial cancer. Simultaneous urine-based detection of CLASP2 and E-cadherin mRNA can efficiently discriminate patients with or without 2-years progression after transurethral resection of the bladder tumor.
    Title: CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dystroglycan binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
 PubMed 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in platelet-derived growth factor receptor-beta signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of axon extension IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle targeting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basal cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cortical microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
colocalizes_with kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in kinetochore microtubule TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with mitotic spindle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CLIP-associating protein 2
Names
CLIP-associating protein CLASP2
multiple asters (Mast)-like homolog 2
protein Orbit homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001207044.3 → NP_001193973.1  CLIP-associating protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001193973.1

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Consensus CDS
    CCDS93234.1
    UniProtKB/Swiss-Prot
    B2RTR1, F5H604, O75122, Q7L8F6, Q8N6R6, Q9BQT3, Q9BQT4, Q9H7A3, Q9NSZ2
    UniProtKB/TrEMBL
    E3W994
    Related
    ENSP00000417518.2, ENST00000480013.6
    Conserved Domains (2) summary
    sd00044
    Location:655 → 682
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94 → 305
    CLASP_N; CLASP N terminal

  2. NM_001365627.1 → NP_001352556.1  CLIP-associating protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  3. NM_001365628.1 → NP_001352557.1  CLIP-associating protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal

  4. NM_001365629.1 → NP_001352558.1  CLIP-associating protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  5. NM_001365630.1 → NP_001352559.1  CLIP-associating protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  6. NM_001365631.1 → NP_001352560.1  CLIP-associating protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Consensus CDS
    CCDS93235.1
    UniProtKB/TrEMBL
    A0A804HJG7, E3W994
    Related
    ENSP00000507498.1, ENST00000682230.1
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  7. NM_001365632.1 → NP_001352561.1  CLIP-associating protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  8. NM_001365633.1 → NP_001352562.1  CLIP-associating protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal

  9. NM_001365634.1 → NP_001352563.1  CLIP-associating protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  10. NM_001375694.1 → NP_001362623.1  CLIP-associating protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (4) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal
    cl41918
    Location:671 → 759
    CoV_N-NTD; N-terminal domain of nucleocapsid (N) protein of coronavirus

  11. NM_001375697.1 → NP_001362626.1  CLIP-associating protein 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  12. NM_001375700.1 → NP_001362629.1  CLIP-associating protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (4) summary
    PHA03307
    Location:570 → 786
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  13. NM_001375701.1 → NP_001362630.1  CLIP-associating protein 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Consensus CDS
    CCDS93237.1
    UniProtKB/TrEMBL
    E3W994, E7EW49
    Related
    ENSP00000419974.2, ENST00000468888.6
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal

  14. NM_001375703.1 → NP_001362632.1  CLIP-associating protein 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal

  15. NM_001375705.1 → NP_001362634.1  CLIP-associating protein 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (4) summary
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal
    cl41918
    Location:657 → 745
    CoV_N-NTD; N-terminal domain of nucleocapsid (N) protein of coronavirus

  16. NM_001375713.1 → NP_001362642.1  CLIP-associating protein 2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    sd00044
    Location:32 → 58
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:69 → 99
    HEAT; HEAT repeat
    pfam12348
    Location:228 → 439
    CLASP_N; CLASP N terminal

  17. NM_001375715.1 → NP_001362644.1  CLIP-associating protein 2 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (2) summary
    sd00044
    Location:1059 → 1081
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94 → 305
    CLASP_N; CLASP N terminal

  18. NM_001375716.1 → NP_001362645.1  CLIP-associating protein 2 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (2) summary
    sd00044
    Location:641 → 668
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:101 → 312
    CLASP_N; CLASP N terminal

  19. NM_001375718.1 → NP_001362647.1  CLIP-associating protein 2 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (2) summary
    sd00044
    Location:640 → 667
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:100 → 311
    CLASP_N; CLASP N terminal

  20. NM_001375720.1 → NP_001362649.1  CLIP-associating protein 2 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Related
    ENSP00000419305.3, ENST00000461133.8
    Conserved Domains (2) summary
    sd00044
    Location:634 → 661
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94 → 305
    CLASP_N; CLASP N terminal

  21. NM_001400405.1 → NP_001387334.1  CLIP-associating protein 2 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  22. NM_001400406.1 → NP_001387335.1  CLIP-associating protein 2 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  23. NM_001400407.1 → NP_001387336.1  CLIP-associating protein 2 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  24. NM_001400408.1 → NP_001387337.1  CLIP-associating protein 2 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  25. NM_001400409.1 → NP_001387338.1  CLIP-associating protein 2 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  26. NM_001400410.1 → NP_001387339.1  CLIP-associating protein 2 isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  27. NM_001400411.1 → NP_001387340.1  CLIP-associating protein 2 isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  28. NM_001400412.1 → NP_001387341.1  CLIP-associating protein 2 isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  29. NM_001400413.1 → NP_001387342.1  CLIP-associating protein 2 isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  30. NM_001400414.1 → NP_001387343.1  CLIP-associating protein 2 isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Consensus CDS
    CCDS93232.1
    UniProtKB/TrEMBL
    A0A0U1RQI6
    Related
    ENSP00000489023.1, ENST00000635664.1

  31. NM_001400415.1 → NP_001387344.1  CLIP-associating protein 2 isoform 32

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  32. NM_001400416.1 → NP_001387345.1  CLIP-associating protein 2 isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  33. NM_001400417.1 → NP_001387346.1  CLIP-associating protein 2 isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  34. NM_001400418.1 → NP_001387347.1  CLIP-associating protein 2 isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  35. NM_001400419.1 → NP_001387348.1  CLIP-associating protein 2 isoform 35

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  36. NM_001400420.1 → NP_001387349.1  CLIP-associating protein 2 isoform 36

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  37. NM_001400421.1 → NP_001387350.1  CLIP-associating protein 2 isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  38. NM_001400422.1 → NP_001387351.1  CLIP-associating protein 2 isoform 38

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  39. NM_001400423.1 → NP_001387352.1  CLIP-associating protein 2 isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  40. NM_001400424.1 → NP_001387353.1  CLIP-associating protein 2 isoform 40

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  41. NM_001400425.1 → NP_001387354.1  CLIP-associating protein 2 isoform 41

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    Consensus CDS
    CCDS93233.1
    UniProtKB/TrEMBL
    J3KR49
    Related
    ENSP00000498272.1, ENST00000650653.1

  42. NM_001400427.1 → NP_001387356.1  CLIP-associating protein 2 isoform 42

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  43. NM_001400428.1 → NP_001387357.1  CLIP-associating protein 2 isoform 43

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  44. NM_001400429.1 → NP_001387358.1  CLIP-associating protein 2 isoform 44

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  45. NM_001400430.1 → NP_001387359.1  CLIP-associating protein 2 isoform 45

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  46. NM_001400431.1 → NP_001387360.1  CLIP-associating protein 2 isoform 46

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  47. NM_001400432.1 → NP_001387361.1  CLIP-associating protein 2 isoform 47

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  48. NM_001400433.1 → NP_001387362.1  CLIP-associating protein 2 isoform 48

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  49. NM_001400434.1 → NP_001387363.1  CLIP-associating protein 2 isoform 49

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  50. NM_001400435.1 → NP_001387364.1  CLIP-associating protein 2 isoform 50

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  51. NM_001400436.1 → NP_001387365.1  CLIP-associating protein 2 isoform 51

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  52. NM_001400437.1 → NP_001387366.1  CLIP-associating protein 2 isoform 52

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515

  53. NM_015097.3 → NP_055912.2  CLIP-associating protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055912.2

    Status: VALIDATED

    Source sequence(s)
    AC093114, AC113170, AC132515
    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    33496245..33718254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447759.1 → XP_047303715.1  CLIP-associating protein 2 isoform X16

  2. XM_017005949.2 → XP_016861438.1  CLIP-associating protein 2 isoform X8

    UniProtKB/TrEMBL
    E3W994

  3. XM_047447757.1 → XP_047303713.1  CLIP-associating protein 2 isoform X14

  4. XM_047447756.1 → XP_047303712.1  CLIP-associating protein 2 isoform X12

  5. XM_017005959.2 → XP_016861448.1  CLIP-associating protein 2 isoform X19

    UniProtKB/TrEMBL
    E3W994, E7ERI8
    Related
    ENSP00000382297.4, ENST00000399362.8

  6. XM_006713052.2 → XP_006713115.1  CLIP-associating protein 2 isoform X17

    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

  7. XM_017005948.2 → XP_016861437.1  CLIP-associating protein 2 isoform X6

    UniProtKB/TrEMBL
    E3W994

  8. XM_006713041.2 → XP_006713104.1  CLIP-associating protein 2 isoform X4

    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (4) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam10265
    Location:686 → 790
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

  9. XM_047447755.1 → XP_047303711.1  CLIP-associating protein 2 isoform X2

  10. XM_047447761.1 → XP_047303717.1  CLIP-associating protein 2 isoform X21

  11. XM_017005960.2 → XP_016861449.1  CLIP-associating protein 2 isoform X20

    UniProtKB/TrEMBL
    E3W994

  12. XM_047447758.1 → XP_047303714.1  CLIP-associating protein 2 isoform X15

  13. XM_047447760.1 → XP_047303716.1  CLIP-associating protein 2 isoform X18

  14. XM_011533515.2 → XP_011531817.1  CLIP-associating protein 2 isoform X7

    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (4) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam10265
    Location:673 → 777
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

  15. XM_017005957.2 → XP_016861446.1  CLIP-associating protein 2 isoform X13

    UniProtKB/TrEMBL
    E3W994

  16. XM_006713053.2 → XP_006713116.1  CLIP-associating protein 2 isoform X22

    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

  17. XM_006713050.2 → XP_006713113.1  CLIP-associating protein 2 isoform X11

    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

  18. XM_006713048.2 → XP_006713111.1  CLIP-associating protein 2 isoform X9

    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (3) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

  19. XM_017005956.2 → XP_016861445.1  CLIP-associating protein 2 isoform X10

    UniProtKB/TrEMBL
    E3W994

  20. XM_006713042.2 → XP_006713105.1  CLIP-associating protein 2 isoform X5

    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (4) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam10265
    Location:687 → 791
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

  21. XM_006713040.2 → XP_006713103.1  CLIP-associating protein 2 isoform X3

    UniProtKB/TrEMBL
    E3W994
    Conserved Domains (4) summary
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam10265
    Location:687 → 791
    DUF2217; Uncharacterized conserved protein (DUF2217)
    pfam12348
    Location:328 → 539
    CLASP_N; CLASP N terminal
    sd00044
    Location:131 → 157
    HEAT; HEAT repeat [structural motif]

  22. XM_047447754.1 → XP_047303710.1  CLIP-associating protein 2 isoform X1

  23. XM_047447764.1 → XP_047303720.1  CLIP-associating protein 2 isoform X28

  24. XM_017005972.3 → XP_016861461.1  CLIP-associating protein 2 isoform X25

    UniProtKB/TrEMBL
    E3W994

  25. XM_047447763.1 → XP_047303719.1  CLIP-associating protein 2 isoform X27

  26. XM_047447762.1 → XP_047303718.1  CLIP-associating protein 2 isoform X26

  27. XM_017005969.3 → XP_016861458.1  CLIP-associating protein 2 isoform X24

    UniProtKB/TrEMBL
    E3W994

  28. XM_017005968.3 → XP_016861457.1  CLIP-associating protein 2 isoform X23

    UniProtKB/TrEMBL
    E3W994

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    33497978..33719132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345779.1 → XP_054201754.1  CLIP-associating protein 2 isoform X16

  2. XM_054345771.1 → XP_054201746.1  CLIP-associating protein 2 isoform X8

  3. XM_054345777.1 → XP_054201752.1  CLIP-associating protein 2 isoform X14

  4. XM_054345775.1 → XP_054201750.1  CLIP-associating protein 2 isoform X12

  5. XM_054345782.1 → XP_054201757.1  CLIP-associating protein 2 isoform X19

    UniProtKB/TrEMBL
    E7ERI8

  6. XM_054345780.1 → XP_054201755.1  CLIP-associating protein 2 isoform X17

  7. XM_054345769.1 → XP_054201744.1  CLIP-associating protein 2 isoform X6

  8. XM_054345767.1 → XP_054201742.1  CLIP-associating protein 2 isoform X4

  9. XM_054345765.1 → XP_054201740.1  CLIP-associating protein 2 isoform X2

  10. XM_054345784.1 → XP_054201759.1  CLIP-associating protein 2 isoform X21

  11. XM_054345783.1 → XP_054201758.1  CLIP-associating protein 2 isoform X20

  12. XM_054345778.1 → XP_054201753.1  CLIP-associating protein 2 isoform X15

  13. XM_054345781.1 → XP_054201756.1  CLIP-associating protein 2 isoform X18

  14. XM_054345770.1 → XP_054201745.1  CLIP-associating protein 2 isoform X7

  15. XM_054345776.1 → XP_054201751.1  CLIP-associating protein 2 isoform X13

  16. XM_054345785.1 → XP_054201760.1  CLIP-associating protein 2 isoform X22

  17. XM_054345774.1 → XP_054201749.1  CLIP-associating protein 2 isoform X11

  18. XM_054345772.1 → XP_054201747.1  CLIP-associating protein 2 isoform X9

  19. XM_054345773.1 → XP_054201748.1  CLIP-associating protein 2 isoform X10

  20. XM_054345768.1 → XP_054201743.1  CLIP-associating protein 2 isoform X5

  21. XM_054345766.1 → XP_054201741.1  CLIP-associating protein 2 isoform X3

  22. XM_054345764.1 → XP_054201739.1  CLIP-associating protein 2 isoform X1

  23. XM_054345791.1 → XP_054201766.1  CLIP-associating protein 2 isoform X28

  24. XM_054345788.1 → XP_054201763.1  CLIP-associating protein 2 isoform X25

  25. XM_054345790.1 → XP_054201765.1  CLIP-associating protein 2 isoform X27

  26. XM_054345789.1 → XP_054201764.1  CLIP-associating protein 2 isoform X26

  27. XM_054345787.1 → XP_054201762.1  CLIP-associating protein 2 isoform X24

  28. XM_054345786.1 → XP_054201761.1  CLIP-associating protein 2 isoform X23

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75122.3 GenPept UniProtKB/Swiss-Prot:O75122

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