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Plac8 placenta-specific 8 [ Mus musculus (house mouse) ]

Gene ID: 231507, updated on 2-Nov-2024

Summary

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Official Symbol
Plac8provided by MGI
Official Full Name
placenta-specific 8provided by MGI
Primary source
MGI:MGI:2445289
See related
Ensembl:ENSMUSG00000029322 AllianceGenome:MGI:2445289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C15; D5Wsu111e
Summary
Enables chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of transcription by RNA polymerase II; and response to cold. Predicted to be located in nucleoplasm. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver lobe; and prostate gland lobe. Orthologous to human PLAC8 (placenta associated 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in duodenum adult (RPKM 141.6), large intestine adult (RPKM 140.7) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Plac8 in Genome Data Viewer
Location:
5 E4; 5 48.49 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100699455..100720119, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100551589..100572253, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2163 Neighboring gene predicted gene, 19620 Neighboring gene COP9 signalosome subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:100998499-100998608 Neighboring gene STARR-positive B cell enhancer ABC_E11295 Neighboring gene STARR-positive B cell enhancer ABC_E11296 Neighboring gene STARR-positive B cell enhancer mm9_chr5:101027025-101027325 Neighboring gene STARR-positive B cell enhancer ABC_E9256 Neighboring gene STARR-positive B cell enhancer ABC_E8823 Neighboring gene coenzyme Q2 4-hydroxybenzoate polyprenyltransferase Neighboring gene STARR-seq mESC enhancer starr_13729 Neighboring gene heparanase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse. Yang X, et al. Virology, 2021 Dec. PMID 34653773
  2. Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway. Rogulski K, et al. Oncogene, 2005 Nov 17. PMID 16170375
  3. CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model. Lee H, et al. Lab Anim Res, 2018 Dec. PMID 30671116, Free PMC Article
  4. Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo. Jimenez-Preitner M, et al. PLoS One, 2012. PMID 23155406, Free PMC Article
  5. Impaired host defense in mice lacking ONZIN. Ledford JG, et al. J Immunol, 2007 Apr 15. PMID 17404296

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse.
    Title: PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse.
  2. Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
    Title: Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
  3. Results establish PLAC8 as a central mediator of tumor progression in PDAC.
    Title: PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways.
  4. Plac8 provides a mechanistic link between primary oncogenic mutations and the induction of autophagy, a central mechanism of metabolic reprogramming, during PDA progression.
    Title: Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.
  5. Plac8 is an upstream regulator of C/EBPbeta required for adipogenesis in vitro. In vivo, Plac8 is dispensable for the differentiation of white adipocytes with preserved fat storage capacity but is required for normal fat cell count regulation
    Title: Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo.
  6. Data indicate that dampened contact hypersensitivity (CHS) responses correlated with a significant reduction in pro-inflammatory IL-6 at the challenge site in ONZIN-deficient animals.
    Title: ONZIN deficiency attenuates contact hypersensitivity responses in mice.
  7. These results demonstrate that there are two independent and redundant T cell mechanisms for clearing C. muridarum genital tract infections: one dependent on iNOS, and the other dependent on Plac8.
    Title: Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract.
  8. These findings demonstrate a functional interdependence between onzin and PLSCR1.
    Title: The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1.
  9. results identify onzin as a novel regulator of several p53-dependent aspects of the c-Myc phenotype via its dramatic effect on Mdm2
    Title: Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway.
  10. ONZIN as a novel class of intracellular protein required for optimal function of the neutrophils after uptake of bacteria.
    Title: Impaired host defense in mice lacking ONZIN.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
placenta-specific gene 8 protein
Names
onzin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370754.1 → NP_001357683.1  placenta-specific gene 8 protein

    Status: VALIDATED

    Source sequence(s)
    AC109196
    Consensus CDS
    CCDS19464.1
    UniProtKB/Swiss-Prot
    Q9JI48
    Related
    ENSMUSP00000108531.2, ENSMUST00000112910.2
    Conserved Domains (1) summary
    TIGR01571
    Location:21 → 105
    A_thal_Cys_rich; uncharacterized Cys-rich domain

  2. NM_139198.3 → NP_631937.1  placenta-specific gene 8 protein

    See identical proteins and their annotated locations for NP_631937.1

    Status: VALIDATED

    Source sequence(s)
    AC109196
    Consensus CDS
    CCDS19464.1
    UniProtKB/Swiss-Prot
    Q9JI48
    Related
    ENSMUSP00000031264.6, ENSMUST00000031264.12
    Conserved Domains (1) summary
    TIGR01571
    Location:21 → 105
    A_thal_Cys_rich; uncharacterized Cys-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100699455..100720119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254403.1 → XP_030110263.1  placenta-specific gene 8 protein isoform X2

  2. XM_017320850.2 → XP_017176339.1  placenta-specific gene 8 protein isoform X1

  3. XM_030254402.2 → XP_030110262.1  placenta-specific gene 8 protein isoform X1

  4. XM_017320849.3 → XP_017176338.1  placenta-specific gene 8 protein isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI48.1 GenPept UniProtKB/Swiss-Prot:Q9JI48

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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