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CIC capicua transcriptional repressor [ Homo sapiens (human) ]

Gene ID: 23152, updated on 3-Nov-2024

Summary

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Official Symbol
CICprovided by HGNC
Official Full Name
capicua transcriptional repressorprovided by HGNC
Primary source
HGNC:HGNC:14214
See related
Ensembl:ENSG00000079432 MIM:612082; AllianceGenome:HGNC:14214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRD45
Summary
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in testis (RPKM 16.0), endometrium (RPKM 12.0) and 25 other tissues See more
Orthologs
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Genomic context

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See CIC in Genome Data Viewer
Location:
19q13.2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42268530..42295796)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45087903..45115169)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42772682..42799948)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glycogen synthase kinase 3 alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42747245-42748039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42748040-42748833 Neighboring gene Sharpr-MPRA regulatory region 11582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10696 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42758837-42759336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42759977-42760508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42761304-42762125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42762126-42762946 Neighboring gene ETS2 repressor factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14711 Neighboring gene ZFP161 motif-containing MPRA enhancer 284/285 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42784339-42784844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42785857-42786361 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:42787942-42788116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42794166-42795066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14713 Neighboring gene platelet activating factor acetylhydrolase 1b catalytic subunit 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42806463-42807117 Neighboring gene proline rich 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42818801-42819301 Neighboring gene transmembrane protein 145

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel CIC variants identified in individuals with neurodevelopmental phenotypes. Sharma S, et al. Hum Mutat, 2022 Jul. PMID 35165976
  2. Downregulation of CIC does not associate with overexpression of ETV1 or MAP kinase pathway activation in gastrointestinal stromal tumors. Schoppmann SF, et al. Cancer Invest, 2014 Aug. PMID 24897389
  3. Capicua in Human Cancer. Kim JW, et al. Trends Cancer, 2021 Jan. PMID 32978089, Free PMC Article
  4. The "grep" command but not FusionMap, FusionFinder or ChimeraScan captures the CIC-DUX4 fusion gene from whole transcriptome sequencing data on a small round cell tumor with t(4;19)(q35;q13). Panagopoulos I, et al. PLoS One, 2014. PMID 24950227, Free PMC Article
  5. Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma. Hashiba T, et al. Cell Mol Gastroenterol Hepatol, 2020. PMID 32169577, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CIC-Rearranged Sarcoma.
    Title: CIC-Rearranged Sarcoma.
  2. Expanding the Molecular Diversity of CIC-Rearranged Sarcomas With Novel and Very Rare Partners.
    Title: Expanding the Molecular Diversity of CIC-Rearranged Sarcomas With Novel and Very Rare Partners.
  3. A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).
    Title: A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).
  4. CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.
    Title: CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.
  5. CIC missense variants contribute to susceptibility for spina bifida.
    Title: CIC missense variants contribute to susceptibility for spina bifida.
  6. The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression.
    Title: The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression.
  7. Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer.
    Title: Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer.
  8. CIC-NUTM1 Sarcomas Affecting the Spine.
    Title: CIC-NUTM1 Sarcomas Affecting the Spine.
  9. CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression.
    Title: CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression.
  10. Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.
    Title: Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.
Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability, autosomal dominant 45
MedGen: C4539848 OMIM: 617600 GeneReviews: Not available
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Copy number response

Description
Copy number response
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2022-11-08)

ClinGen Genome Curation PagePubMed
Triplosensitivity

No evidence available (Last evaluated 2022-11-08)

ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0306

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in memory ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in social behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein capicua homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042060.1 RefSeqGene

    Range
    5001..32260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_999

mRNA and Protein(s)

  1. NM_001304815.2 → NP_001291744.1  protein capicua homolog isoform CIC-L

    See identical proteins and their annotated locations for NP_001291744.1

    Status: REVIEWED

    Source sequence(s)
    AC006486
    Consensus CDS
    CCDS92632.1
    UniProtKB/Swiss-Prot
    A0A7P0T9K5, Q7LGI1, Q96RK0, Q9UEG5, Q9Y6T1
    Conserved Domains (5) summary
    PHA03247
    Location:1765 → 2185
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK14086
    Location:871 → 1046
    dnaA; chromosomal replication initiator protein DnaA
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:252 → 349
    DUF4819; Domain of unknown function (DUF4819)

  2. NM_001379480.1 → NP_001366409.1  protein capicua homolog isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006486
    Conserved Domains (5) summary
    PHA03247
    Location:1765 → 2184
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK14086
    Location:871 → 1046
    dnaA; chromosomal replication initiator protein DnaA
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:252 → 349
    DUF4819; Domain of unknown function (DUF4819)

  3. NM_001379482.1 → NP_001366411.1  protein capicua homolog isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006486
    Conserved Domains (5) summary
    PHA03247
    Location:1765 → 2185
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK14086
    Location:871 → 1046
    dnaA; chromosomal replication initiator protein DnaA
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:252 → 349
    DUF4819; Domain of unknown function (DUF4819)

  4. NM_001379484.1 → NP_001366413.1  protein capicua homolog isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006486
    UniProtKB/TrEMBL
    A7XAK3
    Conserved Domains (3) summary
    PHA03247
    Location:856 → 1276
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:171 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  5. NM_001379485.1 → NP_001366414.1  protein capicua homolog isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC006486
    UniProtKB/TrEMBL
    A7XAK3
    Conserved Domains (3) summary
    PHA03247
    Location:856 → 1276
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:171 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  6. NM_001386298.1 → NP_001373227.1  protein capicua homolog isoform CIC-L

    Status: REVIEWED

    Source sequence(s)
    AC006486
    Consensus CDS
    CCDS92632.1
    UniProtKB/Swiss-Prot
    A0A7P0T9K5, Q7LGI1, Q96RK0, Q9UEG5, Q9Y6T1
    Related
    ENSP00000505728.1, ENST00000681038.1
    Conserved Domains (5) summary
    PHA03247
    Location:1765 → 2185
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK14086
    Location:871 → 1046
    dnaA; chromosomal replication initiator protein DnaA
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:252 → 349
    DUF4819; Domain of unknown function (DUF4819)

  7. NM_015125.5 → NP_055940.3  protein capicua homolog isoform CIC-S

    See identical proteins and their annotated locations for NP_055940.3

    Status: REVIEWED

    Source sequence(s)
    AC006486
    Consensus CDS
    CCDS12601.1
    UniProtKB/TrEMBL
    A7XAK3
    Related
    ENSP00000458663.2, ENST00000575354.6
    Conserved Domains (2) summary
    COG5648
    Location:171 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42268530..42295796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438497.1 → XP_047294453.1  protein capicua homolog isoform X6

  2. XM_047438493.1 → XP_047294449.1  protein capicua homolog isoform X3

  3. XM_047438498.1 → XP_047294454.1  protein capicua homolog isoform X9

  4. XM_047438495.1 → XP_047294451.1  protein capicua homolog isoform X5

  5. XM_047438503.1 → XP_047294459.1  protein capicua homolog isoform X13

  6. XM_011526665.3 → XP_011524967.1  protein capicua homolog isoform X6

    Conserved Domains (3) summary
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam16090
    Location:252 → 349
    DUF4819; Domain of unknown function (DUF4819)

  7. XM_011526666.3 → XP_011524968.1  protein capicua homolog isoform X9

    Conserved Domains (3) summary
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam16090
    Location:252 → 349
    DUF4819; Domain of unknown function (DUF4819)

  8. XM_024451433.2 → XP_024307201.1  protein capicua homolog isoform X8

    Conserved Domains (5) summary
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:252 → 346
    DUF4819; Domain of unknown function (DUF4819)
    cl26464
    Location:1765 → 2184
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:871 → 1046
    dnaA; chromosomal replication initiation protein; Provisional

  9. XM_024451432.2 → XP_024307200.1  protein capicua homolog isoform X5

    Conserved Domains (5) summary
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:252 → 346
    DUF4819; Domain of unknown function (DUF4819)
    cl26464
    Location:1765 → 2184
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:871 → 1046
    dnaA; chromosomal replication initiation protein; Provisional

  10. XM_047438502.1 → XP_047294458.1  protein capicua homolog isoform X13

  11. XM_011526662.3 → XP_011524964.1  protein capicua homolog isoform X2

    Conserved Domains (3) summary
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam16090
    Location:252 → 349
    DUF4819; Domain of unknown function (DUF4819)

  12. XM_047438500.1 → XP_047294456.1  protein capicua homolog isoform X11

  13. XM_047438496.1 → XP_047294452.1  protein capicua homolog isoform X7

  14. XM_047438504.1 → XP_047294460.1  protein capicua homolog isoform X14

  15. XM_011526664.3 → XP_011524966.1  protein capicua homolog isoform X4

    Conserved Domains (3) summary
    COG5648
    Location:1080 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam16090
    Location:252 → 349
    DUF4819; Domain of unknown function (DUF4819)

  16. XM_047438501.1 → XP_047294457.1  protein capicua homolog isoform X12

  17. XM_047438499.1 → XP_047294455.1  protein capicua homolog isoform X10

    UniProtKB/TrEMBL
    I3L2J0
    Related
    ENSP00000459719.1, ENST00000572681.6

  18. XM_011526667.3 → XP_011524969.1  protein capicua homolog isoform X15

    Conserved Domains (4) summary
    PHA03247
    Location:1516 → 1973
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1065 → 1224
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK14086
    Location:871 → 1046
    dnaA; chromosomal replication initiator protein DnaA
    cd01388
    Location:1108 → 1179
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  19. XM_047438505.1 → XP_047294461.1  protein capicua homolog isoform X16

  20. XM_047438506.1 → XP_047294462.1  protein capicua homolog isoform X17

  21. XM_047438507.1 → XP_047294463.1  protein capicua homolog isoform X18

  22. XM_047438492.1 → XP_047294448.1  protein capicua homolog isoform X1

    UniProtKB/Swiss-Prot
    A0A7P0T9K5, Q7LGI1, Q96RK0, Q9UEG5, Q9Y6T1

  23. XM_047438511.1 → XP_047294467.1  protein capicua homolog isoform X25

  24. XM_047438512.1 → XP_047294468.1  protein capicua homolog isoform X26

  25. XM_047438509.1 → XP_047294465.1  protein capicua homolog isoform X20

  26. XM_047438508.1 → XP_047294464.1  protein capicua homolog isoform X19

  27. XM_005258674.3 → XP_005258731.1  protein capicua homolog isoform X22

    UniProtKB/TrEMBL
    A7XAK3
    Conserved Domains (2) summary
    COG5648
    Location:171 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  28. XM_047438510.1 → XP_047294466.1  protein capicua homolog isoform X23

  29. XM_005258673.3 → XP_005258730.1  protein capicua homolog isoform X21

    UniProtKB/TrEMBL
    A0A0A0MQR4, A7XAK3
    Related
    ENSP00000160740.3, ENST00000160740.7
    Conserved Domains (2) summary
    COG5648
    Location:171 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  30. XM_005258675.3 → XP_005258732.1  protein capicua homolog isoform X24

    UniProtKB/TrEMBL
    A7XAK3
    Conserved Domains (2) summary
    COG5648
    Location:171 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  31. XM_047438513.1 → XP_047294469.1  protein capicua homolog isoform X27

    Related
    ENST00000684265.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45087903..45115169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320321.1 → XP_054176296.1  protein capicua homolog isoform X6

  2. XM_054320315.1 → XP_054176290.1  protein capicua homolog isoform X3

  3. XM_054320324.1 → XP_054176299.1  protein capicua homolog isoform X9

  4. XM_054320318.1 → XP_054176293.1  protein capicua homolog isoform X5

  5. XM_054320329.1 → XP_054176304.1  protein capicua homolog isoform X13

  6. XM_054320319.1 → XP_054176294.1  protein capicua homolog isoform X6

  7. XM_054320323.1 → XP_054176298.1  protein capicua homolog isoform X9

  8. XM_054320322.1 → XP_054176297.1  protein capicua homolog isoform X8

  9. XM_054320317.1 → XP_054176292.1  protein capicua homolog isoform X5

  10. XM_054320328.1 → XP_054176303.1  protein capicua homolog isoform X13

  11. XM_054320314.1 → XP_054176289.1  protein capicua homolog isoform X2

  12. XM_054320326.1 → XP_054176301.1  protein capicua homolog isoform X11

  13. XM_054320320.1 → XP_054176295.1  protein capicua homolog isoform X7

  14. XM_054320330.1 → XP_054176305.1  protein capicua homolog isoform X14

  15. XM_054320316.1 → XP_054176291.1  protein capicua homolog isoform X4

  16. XM_054320327.1 → XP_054176302.1  protein capicua homolog isoform X12

  17. XM_054320325.1 → XP_054176300.1  protein capicua homolog isoform X10

    UniProtKB/TrEMBL
    I3L2J0

  18. XM_054320331.1 → XP_054176306.1  protein capicua homolog isoform X15

  19. XM_054320332.1 → XP_054176307.1  protein capicua homolog isoform X16

  20. XM_054320333.1 → XP_054176308.1  protein capicua homolog isoform X17

  21. XM_054320334.1 → XP_054176309.1  protein capicua homolog isoform X18

  22. XM_054320313.1 → XP_054176288.1  protein capicua homolog isoform X1

    UniProtKB/Swiss-Prot
    A0A7P0T9K5, Q7LGI1, Q96RK0, Q9UEG5, Q9Y6T1

  23. XM_054320341.1 → XP_054176316.1  protein capicua homolog isoform X25

  24. XM_054320342.1 → XP_054176317.1  protein capicua homolog isoform X26

  25. XM_054320335.1 → XP_054176310.1  protein capicua homolog isoform X20

  26. XM_054320336.1 → XP_054176311.1  protein capicua homolog isoform X19

  27. XM_054320338.1 → XP_054176313.1  protein capicua homolog isoform X22

  28. XM_054320339.1 → XP_054176314.1  protein capicua homolog isoform X23

  29. XM_054320337.1 → XP_054176312.1  protein capicua homolog isoform X21

    UniProtKB/TrEMBL
    A0A0A0MQR4

  30. XM_054320340.1 → XP_054176315.1  protein capicua homolog isoform X24

  31. XM_054320343.1 → XP_054176318.1  protein capicua homolog isoform X27

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RK0.3 GenPept UniProtKB/Swiss-Prot:Q96RK0

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