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Ficd FIC domain containing [ Mus musculus (house mouse) ]

Gene ID: 231630, updated on 28-Oct-2024

Summary

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Official Symbol
Ficdprovided by MGI
Official Full Name
FIC domain containingprovided by MGI
Primary source
MGI:MGI:1098550
See related
Ensembl:ENSMUSG00000053334 AllianceGenome:MGI:1098550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hype; D5Ertd40e
Summary
Predicted to enable several functions, including AMPylase activity; ATP binding activity; and Hsp70 protein binding activity. Predicted to be involved in several processes, including protein adenylylation; protein deadenylylation; and regulation of IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Is expressed in central nervous system; genitourinary system; gut gland; and stomach. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 5.9), adrenal adult (RPKM 5.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ficd in Genome Data Viewer
Location:
5 F; 5 55.55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113873821..113878670)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113735758..113740607)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chemerin chemokine-like receptor 1 Neighboring gene predicted gene, 52823 Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene STARR-positive B cell enhancer ABC_E2171 Neighboring gene squamous cell carcinoma antigen recognized by T cells 3 Neighboring gene STARR-seq mESC enhancer starr_14052 Neighboring gene STARR-positive B cell enhancer ABC_E9260 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene iron-sulfur cluster assembly enzyme

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FicD regulates adaptation to the unfolded protein response in the murine liver. Casey AK, et al. Biochimie, 2024 Oct. PMID 38740171
  2. FicD sensitizes cellular response to glucose fluctuations in mouse embryonic fibroblasts. Gulen B, et al. Proc Natl Acad Sci U S A, 2024 Sep 17. PMID 39259589, Free PMC Article
  3. Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo. McCaul N, et al. J Biol Chem, 2021 Sep. PMID 34419450, Free PMC Article
  4. Fic-mediated AMPylation tempers the unfolded protein response during physiological stress. Casey AK, et al. Proc Natl Acad Sci U S A, 2022 Aug 9. PMID 35914137, Free PMC Article
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FicD regulates adaptation to the unfolded protein response in the murine liver.
    Title: FicD regulates adaptation to the unfolded protein response in the murine liver.
  2. FicD sensitizes cellular response to glucose fluctuations in mouse embryonic fibroblasts.
    Title: FicD sensitizes cellular response to glucose fluctuations in mouse embryonic fibroblasts.
  3. Fic-mediated AMPylation tempers the unfolded protein response during physiological stress.
    Title: Fic-mediated AMPylation tempers the unfolded protein response during physiological stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC117722

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMPylase activity ISO
Inferred from Sequence Orthology
more info
  
enables AMPylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein adenylylhydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein adenylylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein adenylylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein deadenylylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of IRE1-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein adenylyltransferase FICD
Names
AMPylator FICD
FIC domain-containing protein
adenosine monophosphate-protein transferase FICD
de-AMPylase FICD
huntingtin interacting protein E
huntingtin interactor protein E
NP_001010825.2
XP_006530348.1
XP_006530349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010825.3 → NP_001010825.2  protein adenylyltransferase FICD

    See identical proteins and their annotated locations for NP_001010825.2

    Status: VALIDATED

    Source sequence(s)
    BC106090, BP765693, BY271260
    Consensus CDS
    CCDS51620.1
    UniProtKB/Swiss-Prot
    A4QPF9, Q8BIC9, Q8BIX9, Q8BJ12
    Related
    ENSMUSP00000071719.5, ENSMUST00000065698.7
    Conserved Domains (3) summary
    COG3177
    Location:227 → 411
    COG3177; Fic family protein [Transcription]
    TIGR02917
    Location:89 → 180
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:106 → 134
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113873821..113878670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530285.5 → XP_006530348.1  protein adenylyltransferase FICD isoform X2

    See identical proteins and their annotated locations for XP_006530348.1

    UniProtKB/Swiss-Prot
    A4QPF9, Q8BIC9, Q8BIX9, Q8BJ12
    Conserved Domains (3) summary
    COG3177
    Location:227 → 411
    COG3177; Fic family protein [Transcription]
    TIGR02917
    Location:89 → 180
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:106 → 134
    TPR; TPR repeat [structural motif]

  2. XM_006530286.4 → XP_006530349.1  protein adenylyltransferase FICD isoform X1

    Conserved Domains (3) summary
    COG3177
    Location:226 → 410
    COG3177; Fic family protein [Transcription]
    TIGR02917
    Location:97 → 179
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:105 → 133
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIX9.1 GenPept UniProtKB/Swiss-Prot:Q8BIX9

Gene LinkOut

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