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KANK1 KN motif and ankyrin repeat domains 1 [ Homo sapiens (human) ]

Gene ID: 23189, updated on 27-Nov-2024

Summary

Official Symbol
KANK1provided by HGNC
Official Full Name
KN motif and ankyrin repeat domains 1provided by HGNC
Primary source
HGNC:HGNC:19309
See related
Ensembl:ENSG00000107104 MIM:607704; AllianceGenome:HGNC:19309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KANK; CPSQ2; ANKRD15
Summary
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in esophagus (RPKM 11.7), heart (RPKM 11.6) and 24 other tissues See more
Orthologs
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Genomic context

See KANK1 in Genome Data Viewer
Location:
9p24.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (470295..746103)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (469752..745414)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (470295..746103)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 8 Neighboring gene uncharacterized LOC124902108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:469879-470404 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:477887-478386 Neighboring gene DOCK8 antisense RNA 2 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19725 Neighboring gene ribosomal protein L12 pseudogene 25 Neighboring gene family with sequence similarity 217 member A pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:537214-537426 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:557803-558354 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:574431-575270 Neighboring gene RNA, U6 small nuclear 1327, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:621337-622536 Neighboring gene MPRA-validated peak7200 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:671014-671514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:671515-672015 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:673911-674631 Neighboring gene phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like Neighboring gene eukaryotic translation initiation factor 1 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:737889-739088 Neighboring gene uncharacterized LOC124902109 Neighboring gene Sharpr-MPRA regulatory region 15053 Neighboring gene uncharacterized LOC105375949

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cerebral palsy, spastic quadriplegic, 2
MedGen: C2752061 OMIM: 612900 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2016-04-28)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2016-04-28)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
EBI GWAS Catalog
Genome-wide association study of lung function decline in adults with and without asthma.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ18161, KIAA0172, MGC43128, DKFZp451G231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cortical microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lamellipodium morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ruffle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in podocyte cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
KN motif and ankyrin repeat domain-containing protein 1
Names
ankyrin repeat domain-containing protein 15
kidney ankyrin repeat-containing protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016331.3 RefSeqGene

    Range
    39402..280810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256876.3NP_001243805.1  KN motif and ankyrin repeat domain-containing protein 1 isoform L

    See identical proteins and their annotated locations for NP_001243805.1

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS34976.1
    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Related
    ENSP00000371740.1, ENST00000382303.5
    Conserved Domains (4) summary
    cd00204
    Location:11561287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12341264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001256877.3NP_001243806.1  KN motif and ankyrin repeat domain-containing protein 1 isoform L

    See identical proteins and their annotated locations for NP_001243806.1

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725, AL392089
    Consensus CDS
    CCDS34976.1
    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:11561287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12341264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001354331.2NP_001341260.1  KN motif and ankyrin repeat domain-containing protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS94372.1
    UniProtKB/TrEMBL
    A0A8I5KT40, A8KAC4
    Related
    ENSP00000509034.1, ENST00000691319.1
    Conserved Domains (6) summary
    COG0666
    Location:10531208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG1196
    Location:260484
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG1511
    Location:6961103
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    sd00045
    Location:11541184
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    pfam12796
    Location:11581243
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_001354332.2NP_001341261.1  KN motif and ankyrin repeat domain-containing protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:11381269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12161246
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001354333.2NP_001341262.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Conserved Domains (3) summary
    cd00204
    Location:9981129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10761106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001354334.2NP_001341263.1  KN motif and ankyrin repeat domain-containing protein 1 isoform L

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS34976.1
    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Related
    ENSP00000508451.1, ENST00000689779.1
    Conserved Domains (4) summary
    cd00204
    Location:11561287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12341264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001354335.2NP_001341264.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Related
    ENSP00000509433.1, ENST00000690372.1
    Conserved Domains (3) summary
    cd00204
    Location:9981129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10761106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001354336.2NP_001341265.1  KN motif and ankyrin repeat domain-containing protein 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS94373.1
    UniProtKB/TrEMBL
    A0A8I5KRP2, A0A8I5KUM3
    Conserved Domains (4) summary
    cd00204
    Location:9001031
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:9781008
    ANK; ANK repeat [structural motif]
    cl19580
    Location:538927
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001354337.2NP_001341266.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Related
    ENSP00000510058.1, ENST00000687796.1
    Conserved Domains (3) summary
    cd00204
    Location:9981129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10761106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_001354338.2NP_001341267.1  KN motif and ankyrin repeat domain-containing protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL136979
    UniProtKB/TrEMBL
    Q6PIB3
    Conserved Domains (3) summary
    cd00204
    Location:9801111
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10581088
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001354339.2NP_001341268.1  KN motif and ankyrin repeat domain-containing protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS94374.1
    UniProtKB/TrEMBL
    A0A8I5KUD8, A0A8I5KZ49
    Related
    ENSP00000510316.1, ENST00000692757.1
    Conserved Domains (4) summary
    cd00204
    Location:9181049
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:9961026
    ANK; ANK repeat [structural motif]
    cl19580
    Location:538945
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_001354340.2NP_001341269.1  KN motif and ankyrin repeat domain-containing protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL136979
    UniProtKB/TrEMBL
    Q6PIB3
    Conserved Domains (3) summary
    cd00204
    Location:9801111
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10581088
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  13. NM_001354341.2NP_001341270.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Conserved Domains (3) summary
    cd00204
    Location:9981129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10761106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  14. NM_001354342.2NP_001341271.1  KN motif and ankyrin repeat domain-containing protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS94374.1
    UniProtKB/TrEMBL
    A0A8I5KUD8, A0A8I5KZ49
    Related
    ENSP00000510515.1, ENST00000693143.1
    Conserved Domains (4) summary
    cd00204
    Location:9181049
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:9961026
    ANK; ANK repeat [structural motif]
    cl19580
    Location:538945
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  15. NM_001354343.2NP_001341272.1  KN motif and ankyrin repeat domain-containing protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS94374.1
    UniProtKB/TrEMBL
    A0A8I5KUD8, A0A8I5KZ49
    Conserved Domains (4) summary
    cd00204
    Location:9181049
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:9961026
    ANK; ANK repeat [structural motif]
    cl19580
    Location:538945
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  16. NM_001354344.2NP_001341273.1  KN motif and ankyrin repeat domain-containing protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL136979
    UniProtKB/TrEMBL
    Q6PIB3
    Related
    ENSP00000508606.1, ENST00000685380.1
    Conserved Domains (3) summary
    cd00204
    Location:9801111
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10581088
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain
  17. NM_015158.5NP_055973.2  KN motif and ankyrin repeat domain-containing protein 1 isoform L

    See identical proteins and their annotated locations for NP_055973.2

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS34976.1
    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Related
    ENSP00000371734.2, ENST00000382297.7
    Conserved Domains (4) summary
    cd00204
    Location:11561287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12341264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  18. NM_153186.6NP_694856.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Related
    ENSP00000371730.3, ENST00000382293.7
    Conserved Domains (3) summary
    cd00204
    Location:9981129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10761106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106370
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_148869.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Related
    ENST00000688039.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    470295..746103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423041.1XP_047278997.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  2. XM_047423067.1XP_047279023.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40
  3. XM_047423060.1XP_047279016.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  4. XM_047423073.1XP_047279029.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  5. XM_047423058.1XP_047279014.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  6. XM_047423040.1XP_047278996.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  7. XM_047423066.1XP_047279022.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40
  8. XM_047423059.1XP_047279015.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  9. XM_047423049.1XP_047279005.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  10. XM_047423053.1XP_047279009.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  11. XM_047423050.1XP_047279006.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  12. XM_047423043.1XP_047278999.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  13. XM_047423051.1XP_047279007.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  14. XM_047423047.1XP_047279003.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  15. XM_047423048.1XP_047279004.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  16. XM_047423042.1XP_047278998.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  17. XM_047423044.1XP_047279000.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  18. XM_047423052.1XP_047279008.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  19. XM_047423057.1XP_047279013.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  20. XM_024447463.2XP_024303231.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:11561287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12341264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  21. XM_024447465.2XP_024303233.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:11561287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12341264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  22. XM_047423069.1XP_047279025.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40
  23. XM_047423062.1XP_047279018.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  24. XM_047423056.1XP_047279012.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  25. XM_047423045.1XP_047279001.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  26. XM_047423068.1XP_047279024.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40
    Related
    ENSP00000510088.1, ENST00000689926.1
  27. XM_047423061.1XP_047279017.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  28. XM_047423071.1XP_047279027.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  29. XM_047423055.1XP_047279011.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  30. XM_047423054.1XP_047279010.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    Related
    ENSP00000508833.1, ENST00000685947.1
  31. XM_047423065.1XP_047279021.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  32. XM_024447466.2XP_024303234.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:11561287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12341264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  33. XM_024447467.2XP_024303235.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:11561287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:12341264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    cl25732
    Location:264528
    SMC_N; RecF/RecN/SMC N terminal domain
  34. XM_047423063.1XP_047279019.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  35. XM_047423046.1XP_047279002.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
  36. XM_047423070.1XP_047279026.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40
  37. XM_047423064.1XP_047279020.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  38. XM_047423072.1XP_047279028.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  39. XM_047423074.1XP_047279030.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X5

  40. XM_047423076.1XP_047279032.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5KZ49
  41. XM_047423075.1XP_047279031.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X6

  42. XM_047423077.1XP_047279033.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5KRP2
  43. XM_047423079.1XP_047279035.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X9

  44. XM_047423078.1XP_047279034.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5KRP2
    Related
    ENSP00000509347.1, ENST00000693021.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    469752..745414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362460.1XP_054218435.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  2. XM_054362463.1XP_054218438.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  3. XM_054362468.1XP_054218443.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  4. XM_054362485.1XP_054218460.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  5. XM_054362478.1XP_054218453.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  6. XM_054362476.1XP_054218451.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  7. XM_054362477.1XP_054218452.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  8. XM_054362470.1XP_054218445.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  9. XM_054362472.1XP_054218447.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  10. XM_054362475.1XP_054218450.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  11. XM_054362461.1XP_054218436.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  12. XM_054362488.1XP_054218463.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  13. XM_054362481.1XP_054218456.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  14. XM_054362473.1XP_054218448.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  15. XM_054362464.1XP_054218439.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  16. XM_054362487.1XP_054218462.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  17. XM_054362480.1XP_054218455.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  18. XM_054362462.1XP_054218437.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  19. XM_054362492.1XP_054218467.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  20. XM_054362490.1XP_054218465.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  21. XM_054362483.1XP_054218458.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  22. XM_054362465.1XP_054218440.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  23. XM_054362474.1XP_054218449.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  24. XM_054362471.1XP_054218446.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  25. XM_054362486.1XP_054218461.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  26. XM_054362479.1XP_054218454.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  27. XM_054362494.1XP_054218469.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  28. XM_054362489.1XP_054218464.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  29. XM_054362469.1XP_054218444.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  30. XM_054362482.1XP_054218457.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  31. XM_054362466.1XP_054218441.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  32. XM_054362467.1XP_054218442.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  33. XM_054362491.1XP_054218466.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  34. XM_054362484.1XP_054218459.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  35. XM_054362493.1XP_054218468.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  36. XM_054362500.1XP_054218475.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X9

  37. XM_054362498.1XP_054218473.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X8

  38. XM_054362496.1XP_054218471.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X6

  39. XM_054362497.1XP_054218472.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X7

  40. XM_054362495.1XP_054218470.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X5

  41. XM_054362499.1XP_054218474.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X8