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KANK1 KN motif and ankyrin repeat domains 1 [ Homo sapiens (human) ]

Gene ID: 23189, updated on 2-Nov-2024

Summary

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Official Symbol
KANK1provided by HGNC
Official Full Name
KN motif and ankyrin repeat domains 1provided by HGNC
Primary source
HGNC:HGNC:19309
See related
Ensembl:ENSG00000107104 MIM:607704; AllianceGenome:HGNC:19309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KANK; CPSQ2; ANKRD15
Summary
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in esophagus (RPKM 11.7), heart (RPKM 11.6) and 24 other tissues See more
Orthologs
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Genomic context

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See KANK1 in Genome Data Viewer
Location:
9p24.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (470295..746103)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (469752..745414)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (470295..746103)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 8 Neighboring gene uncharacterized LOC124902108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:469879-470404 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:477887-478386 Neighboring gene DOCK8 antisense RNA 2 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19725 Neighboring gene ribosomal protein L12 pseudogene 25 Neighboring gene family with sequence similarity 217 member A pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:537214-537426 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:557803-558354 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:574431-575270 Neighboring gene RNA, U6 small nuclear 1327, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:621337-622536 Neighboring gene MPRA-validated peak7200 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:671014-671514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:671515-672015 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:673911-674631 Neighboring gene phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like Neighboring gene eukaryotic translation initiation factor 1 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:737889-739088 Neighboring gene uncharacterized LOC124902109 Neighboring gene Sharpr-MPRA regulatory region 15053 Neighboring gene uncharacterized LOC105375949

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulation of the Kank1 gene inhibits human lung cancer progression in vitro and in vivo. Gu Y, et al. Oncol Rep, 2018 Sep. PMID 29956815
  2. Familial KANK1 deletion that does not follow expected imprinting pattern. Vanzo RJ, et al. Eur J Med Genet, 2013 May. PMID 23454270
  3. Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase. Guo X, et al. Int J Oncol, 2014 Mar. PMID 24399197
  4. Kank1 reexpression induced by 5-Aza-2'-deoxycytidine suppresses nasopharyngeal carcinoma cell proliferation and promotes apoptosis. Luo FY, et al. Int J Clin Exp Pathol, 2015. PMID 25973051, Free PMC Article
  5. In vivo and in vitro inhibition of human gastric cancer progress by upregulating Kank1 gene. Chen T, et al. Oncol Rep, 2017 Sep. PMID 28731169

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and Characterization of the Roles of circCASP9 in Gastric Cancer Based on a circRNA-miRNA-mRNA Regulatory Network.
    Title: Identification and Characterization of the Roles of circCASP9 in Gastric Cancer Based on a circRNA-miRNA-mRNA Regulatory Network.
  2. TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.
    Title: TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.
  3. KANK family proteins in cancer.
    Title: KANK family proteins in cancer.
  4. Long non-coding RNA CASC2 enhances cisplatin sensitivity in oral squamous cell cancer cells by the miR-31-5p/KANK1 axis.
    Title: Long non-coding RNA CASC2 enhances cisplatin sensitivity in oral squamous cell cancer cells by the miR-31-5p/KANK1 axis.
  5. KANK1 regulates paclitaxel resistance in lung adenocarcinoma A549 cells.
    Title: KANK1 regulates paclitaxel resistance in lung adenocarcinoma A549 cells.
  6. KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas.
    Title: KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas.
  7. Aberrant Kank1 expression regulates YAP to promote apoptosis and inhibit proliferation in OSCC.
    Title: Aberrant Kank1 expression regulates YAP to promote apoptosis and inhibit proliferation in OSCC.
  8. Small interstitial 9p24.3 deletions principally involving KANK1 are likely benign copy number variants.
    Title: Small interstitial 9p24.3 deletions principally involving KANK1 are likely benign copy number variants.
  9. These results indicate that the talin-KANK1 complex is mechanically strong, enabling it to support the cross-talk between microtubule and actin cytoskeleton at focal adhesions.
    Title: Force-Dependent Regulation of Talin-KANK1 Complex at Focal Adhesions.
  10. KANK1 protein is required for targeting microtubules to focal adhesions.
    Title: A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cerebral palsy, spastic quadriplegic, 2
MedGen: C2752061 OMIM: 612900 GeneReviews: Not available
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Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2016-04-28)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2016-04-28)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
EBI GWAS Catalog
Genome-wide association study of lung function decline in adults with and without asthma.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18161, KIAA0172, MGC43128, DKFZp451G231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lamellipodium morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of ruffle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in podocyte cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 1
Names
ankyrin repeat domain-containing protein 15
kidney ankyrin repeat-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016331.3 RefSeqGene

    Range
    39402..280810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256876.3 → NP_001243805.1  KN motif and ankyrin repeat domain-containing protein 1 isoform L

    See identical proteins and their annotated locations for NP_001243805.1

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS34976.1
    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Related
    ENSP00000371740.1, ENST00000382303.5
    Conserved Domains (4) summary
    cd00204
    Location:1156 → 1287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1234 → 1264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_001256877.3 → NP_001243806.1  KN motif and ankyrin repeat domain-containing protein 1 isoform L

    See identical proteins and their annotated locations for NP_001243806.1

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725, AL392089
    Consensus CDS
    CCDS34976.1
    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:1156 → 1287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1234 → 1264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_001354331.2 → NP_001341260.1  KN motif and ankyrin repeat domain-containing protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS94372.1
    UniProtKB/TrEMBL
    A0A8I5KT40, A8KAC4
    Related
    ENSP00000509034.1, ENST00000691319.1
    Conserved Domains (6) summary
    COG0666
    Location:1053 → 1208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG1196
    Location:260 → 484
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG1511
    Location:696 → 1103
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    sd00045
    Location:1154 → 1184
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    pfam12796
    Location:1158 → 1243
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_001354332.2 → NP_001341261.1  KN motif and ankyrin repeat domain-containing protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:1138 → 1269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1216 → 1246
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001354333.2 → NP_001341262.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Conserved Domains (3) summary
    cd00204
    Location:998 → 1129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1076 → 1106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  6. NM_001354334.2 → NP_001341263.1  KN motif and ankyrin repeat domain-containing protein 1 isoform L

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS34976.1
    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Related
    ENSP00000508451.1, ENST00000689779.1
    Conserved Domains (4) summary
    cd00204
    Location:1156 → 1287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1234 → 1264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  7. NM_001354335.2 → NP_001341264.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Related
    ENSP00000509433.1, ENST00000690372.1
    Conserved Domains (3) summary
    cd00204
    Location:998 → 1129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1076 → 1106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  8. NM_001354336.2 → NP_001341265.1  KN motif and ankyrin repeat domain-containing protein 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS94373.1
    UniProtKB/TrEMBL
    A0A8I5KRP2, A0A8I5KUM3
    Conserved Domains (4) summary
    cd00204
    Location:900 → 1031
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:978 → 1008
    ANK; ANK repeat [structural motif]
    cl19580
    Location:538 → 927
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  9. NM_001354337.2 → NP_001341266.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Related
    ENSP00000510058.1, ENST00000687796.1
    Conserved Domains (3) summary
    cd00204
    Location:998 → 1129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1076 → 1106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  10. NM_001354338.2 → NP_001341267.1  KN motif and ankyrin repeat domain-containing protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL136979
    UniProtKB/TrEMBL
    Q6PIB3
    Conserved Domains (3) summary
    cd00204
    Location:980 → 1111
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1058 → 1088
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  11. NM_001354339.2 → NP_001341268.1  KN motif and ankyrin repeat domain-containing protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS94374.1
    UniProtKB/TrEMBL
    A0A8I5KUD8, A0A8I5KZ49
    Related
    ENSP00000510316.1, ENST00000692757.1
    Conserved Domains (4) summary
    cd00204
    Location:918 → 1049
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:996 → 1026
    ANK; ANK repeat [structural motif]
    cl19580
    Location:538 → 945
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  12. NM_001354340.2 → NP_001341269.1  KN motif and ankyrin repeat domain-containing protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL136979
    UniProtKB/TrEMBL
    Q6PIB3
    Conserved Domains (3) summary
    cd00204
    Location:980 → 1111
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1058 → 1088
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  13. NM_001354341.2 → NP_001341270.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Conserved Domains (3) summary
    cd00204
    Location:998 → 1129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1076 → 1106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  14. NM_001354342.2 → NP_001341271.1  KN motif and ankyrin repeat domain-containing protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS94374.1
    UniProtKB/TrEMBL
    A0A8I5KUD8, A0A8I5KZ49
    Related
    ENSP00000510515.1, ENST00000693143.1
    Conserved Domains (4) summary
    cd00204
    Location:918 → 1049
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:996 → 1026
    ANK; ANK repeat [structural motif]
    cl19580
    Location:538 → 945
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  15. NM_001354343.2 → NP_001341272.1  KN motif and ankyrin repeat domain-containing protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS94374.1
    UniProtKB/TrEMBL
    A0A8I5KUD8, A0A8I5KZ49
    Conserved Domains (4) summary
    cd00204
    Location:918 → 1049
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:996 → 1026
    ANK; ANK repeat [structural motif]
    cl19580
    Location:538 → 945
    YhgE; Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  16. NM_001354344.2 → NP_001341273.1  KN motif and ankyrin repeat domain-containing protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL136979
    UniProtKB/TrEMBL
    Q6PIB3
    Related
    ENSP00000508606.1, ENST00000685380.1
    Conserved Domains (3) summary
    cd00204
    Location:980 → 1111
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1058 → 1088
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

  17. NM_015158.5 → NP_055973.2  KN motif and ankyrin repeat domain-containing protein 1 isoform L

    See identical proteins and their annotated locations for NP_055973.2

    Status: REVIEWED

    Source sequence(s)
    AL136979, AL161725
    Consensus CDS
    CCDS34976.1
    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Related
    ENSP00000371734.2, ENST00000382297.7
    Conserved Domains (4) summary
    cd00204
    Location:1156 → 1287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1234 → 1264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  18. NM_153186.6 → NP_694856.1  KN motif and ankyrin repeat domain-containing protein 1 isoform S

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Consensus CDS
    CCDS6441.1
    UniProtKB/TrEMBL
    Q6PIB3
    Related
    ENSP00000371730.3, ENST00000382293.7
    Conserved Domains (3) summary
    cd00204
    Location:998 → 1129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1076 → 1106
    ANK; ANK repeat [structural motif]
    cl25732
    Location:106 → 370
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_148869.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136979
    Related
    ENST00000688039.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    470295..746103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423041.1 → XP_047278997.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  2. XM_047423067.1 → XP_047279023.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40

  3. XM_047423060.1 → XP_047279016.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  4. XM_047423073.1 → XP_047279029.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  5. XM_047423058.1 → XP_047279014.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  6. XM_047423040.1 → XP_047278996.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  7. XM_047423066.1 → XP_047279022.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40

  8. XM_047423059.1 → XP_047279015.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  9. XM_047423049.1 → XP_047279005.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  10. XM_047423053.1 → XP_047279009.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  11. XM_047423050.1 → XP_047279006.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  12. XM_047423043.1 → XP_047278999.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  13. XM_047423051.1 → XP_047279007.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  14. XM_047423047.1 → XP_047279003.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  15. XM_047423048.1 → XP_047279004.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  16. XM_047423042.1 → XP_047278998.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  17. XM_047423044.1 → XP_047279000.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  18. XM_047423052.1 → XP_047279008.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  19. XM_047423057.1 → XP_047279013.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  20. XM_024447463.2 → XP_024303231.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:1156 → 1287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1234 → 1264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  21. XM_024447465.2 → XP_024303233.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:1156 → 1287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1234 → 1264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  22. XM_047423069.1 → XP_047279025.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40

  23. XM_047423062.1 → XP_047279018.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  24. XM_047423056.1 → XP_047279012.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  25. XM_047423045.1 → XP_047279001.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  26. XM_047423068.1 → XP_047279024.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40
    Related
    ENSP00000510088.1, ENST00000689926.1

  27. XM_047423061.1 → XP_047279017.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  28. XM_047423071.1 → XP_047279027.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  29. XM_047423055.1 → XP_047279011.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  30. XM_047423054.1 → XP_047279010.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    Related
    ENSP00000508833.1, ENST00000685947.1

  31. XM_047423065.1 → XP_047279021.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  32. XM_024447466.2 → XP_024303234.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:1156 → 1287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1234 → 1264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  33. XM_024447467.2 → XP_024303235.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74
    UniProtKB/TrEMBL
    A8KAC4
    Conserved Domains (4) summary
    cd00204
    Location:1156 → 1287
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1234 → 1264
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    cl25732
    Location:264 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  34. XM_047423063.1 → XP_047279019.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  35. XM_047423046.1 → XP_047279002.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A2W8, D3DRH3, Q14678, Q5W0W0, Q8IY65, Q8WX74

  36. XM_047423070.1 → XP_047279026.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KT40

  37. XM_047423064.1 → XP_047279020.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  38. XM_047423072.1 → XP_047279028.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  39. XM_047423074.1 → XP_047279030.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X5

  40. XM_047423076.1 → XP_047279032.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5KZ49

  41. XM_047423075.1 → XP_047279031.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X6

  42. XM_047423077.1 → XP_047279033.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5KRP2

  43. XM_047423079.1 → XP_047279035.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X9

  44. XM_047423078.1 → XP_047279034.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5KRP2
    Related
    ENSP00000509347.1, ENST00000693021.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    469752..745414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362460.1 → XP_054218435.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  2. XM_054362463.1 → XP_054218438.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  3. XM_054362468.1 → XP_054218443.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  4. XM_054362485.1 → XP_054218460.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  5. XM_054362478.1 → XP_054218453.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  6. XM_054362476.1 → XP_054218451.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  7. XM_054362477.1 → XP_054218452.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  8. XM_054362470.1 → XP_054218445.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  9. XM_054362472.1 → XP_054218447.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  10. XM_054362475.1 → XP_054218450.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  11. XM_054362461.1 → XP_054218436.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  12. XM_054362488.1 → XP_054218463.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  13. XM_054362481.1 → XP_054218456.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  14. XM_054362473.1 → XP_054218448.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  15. XM_054362464.1 → XP_054218439.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  16. XM_054362487.1 → XP_054218462.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  17. XM_054362480.1 → XP_054218455.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  18. XM_054362462.1 → XP_054218437.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  19. XM_054362492.1 → XP_054218467.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  20. XM_054362490.1 → XP_054218465.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  21. XM_054362483.1 → XP_054218458.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  22. XM_054362465.1 → XP_054218440.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  23. XM_054362474.1 → XP_054218449.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  24. XM_054362471.1 → XP_054218446.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  25. XM_054362486.1 → XP_054218461.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  26. XM_054362479.1 → XP_054218454.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  27. XM_054362494.1 → XP_054218469.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  28. XM_054362489.1 → XP_054218464.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  29. XM_054362469.1 → XP_054218444.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  30. XM_054362482.1 → XP_054218457.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  31. XM_054362466.1 → XP_054218441.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  32. XM_054362467.1 → XP_054218442.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X1

  33. XM_054362491.1 → XP_054218466.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

  34. XM_054362484.1 → XP_054218459.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

  35. XM_054362493.1 → XP_054218468.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

  36. XM_054362500.1 → XP_054218475.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X9

  37. XM_054362498.1 → XP_054218473.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X8

  38. XM_054362496.1 → XP_054218471.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X6

  39. XM_054362497.1 → XP_054218472.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X7

  40. XM_054362495.1 → XP_054218470.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X5

  41. XM_054362499.1 → XP_054218474.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14678.3 GenPept UniProtKB/Swiss-Prot:Q14678

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