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FAM168A family with sequence similarity 168 member A [ Homo sapiens (human) ]

Gene ID: 23201, updated on 7-Apr-2024

Summary

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Official Symbol
FAM168Aprovided by HGNC
Official Full Name
family with sequence similarity 168 member Aprovided by HGNC
Primary source
HGNC:HGNC:28999
See related
Ensembl:ENSG00000054965 MIM:616316; AllianceGenome:HGNC:28999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCRP1; KIAA0280
Summary
Involved in positive regulation of base-excision repair. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 45.1), gall bladder (RPKM 10.1) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.4
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73400487..73598112, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73329624..73527246, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73111532..73309157, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene uncharacterized LOC124902710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73044313-73045026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73061599-73062100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73073093-73073599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3742 Neighboring gene Sharpr-MPRA regulatory region 2034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73097219-73098168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73098169-73099116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73099117-73100064 Neighboring gene RELT TNF receptor Neighboring gene MPRA-validated peak1349 silencer Neighboring gene MPRA-validated peak1350 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73166211-73166710 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:73205355-73205873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73205874-73206391 Neighboring gene NANOG hESC enhancer GRCh37_chr11:73262685-73263225 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:73264745-73264969 Neighboring gene Sharpr-MPRA regulatory region 14801 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73308491-73309219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3745 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 38 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73336706-73337222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73337223-73337737 Neighboring gene MIA SH3 domain ER export factor 2 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73357191-73358109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5239 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:73371326-73372170 and GRCh37_chr11:73372171-73373013 Neighboring gene pleckstrin homology domain containing B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FAM168A participates in the development of chronic myeloid leukemia via BCR-ABL1/AKT1/NFκB pathway. Liu X, et al. BMC Cancer, 2019 Jul 10. PMID 31291942, Free PMC Article
  2. Purification and biochemical characterization of a novel protein-tongue cancer chemotherapy resistance-associated protein1 (TCRP1). Peng B, et al. Protein Expr Purif, 2012 Apr. PMID 22365988
  3. TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway. Gu Y, et al. Mol Cell Biochem, 2011 Nov. PMID 21603883
  4. Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line. Gu Y, et al. FEBS Lett, 2011 Mar 23. PMID 21334329
  5. TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF‑7 cells. Zhao S, et al. Oncol Rep, 2020 Jun. PMID 32323833, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF7 cells.
    Title: TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF‑7 cells.
  2. FAM168A involved in the regulation of AKT1/NFkappaB signaling pathway and cell cycle in chronic myeloid leukemia.
    Title: FAM168A participates in the development of chronic myeloid leukemia via BCR-ABL1/AKT1/NFκB pathway.
  3. Combined, these findings suggest that c-Myc could transcriptionally regulate TCRP1 in cell lines and clinical samples and identified the c-Myc-TCRP1 axis as a negative biomarker of prognosis in tongue and lung cancers.
    Title: TCRP1 transcriptionally regulated by c-Myc confers cancer chemoresistance in tongue and lung cancer.
  4. Our results highlight that hyper-methylation of miR-493CpG island might play important roles in the development of lung cancer chemo-resistance by targeting TCRP1, which might be used as a potential therapeutic target in preventing the chemo-resistance of lung cancer.
    Title: Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1).
  5. Data show that tongue cancer resistance-associated protein 1 (TCRP1) contributes to cisplatin (DDP) resistance via the increased expression of DNA polymerase beta subunit (Pol beta) in lung cancer cells.
    Title: TCRP1 contributes to cisplatin resistance by preventing Pol β degradation in lung cancer cells.
  6. siRNA-mediated knockdown of TCRP1 and MT1X was found to sensitize cells to cisplatin, leading to increased apoptosis and inhibition of cell proliferation
    Title: Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.
  7. these results provided strong evidence for the linkage between TCRP1 and radiation sensitivity and may provide theoretical base of TCRP1 as a potential molecular mark of estimating the response for irradiation in oral squamous cell carcinoma.
    Title: TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway.
  8. Data suggest that TCRP1 (EF363480) might be a novel molecular target to develop agents to reverse cisplatin-induced chemoresistance.
    Title: Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of base-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein FAM168A
Names
tongue cancer chemotherapy resistance-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286050.2 → NP_001272979.1  protein FAM168A isoform 1

    See identical proteins and their annotated locations for NP_001272979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP000763, BC052341, D87470, DB074440
    Consensus CDS
    CCDS73346.1
    UniProtKB/Swiss-Prot
    A2ICY2, A2ID81, Q86UG2, Q92567
    Related
    ENSP00000064778.4, ENST00000064778.8
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 244
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  2. NM_001286051.2 → NP_001272980.1  protein FAM168A isoform 3

    See identical proteins and their annotated locations for NP_001272980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AP000763, DB074440, EF197985
    Consensus CDS
    CCDS66165.1
    UniProtKB/Swiss-Prot
    Q92567
    Related
    ENSP00000390501.2, ENST00000450446.6
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 129
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  3. NM_015159.3 → NP_055974.1  protein FAM168A isoform 2

    See identical proteins and their annotated locations for NP_055974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AP000763, BC052341
    Consensus CDS
    CCDS41689.1
    UniProtKB/Swiss-Prot
    Q92567
    Related
    ENSP00000348852.4, ENST00000356467.5
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 235
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    73400487..73598112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426650.1 → XP_047282606.1  protein FAM168A isoform X1

  2. XM_017017415.3 → XP_016872904.1  protein FAM168A isoform X2

    Conserved Domains (1) summary
    pfam14944
    Location:1 → 193
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    73329624..73527246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368190.1 → XP_054224165.1  protein FAM168A isoform X1

  2. XM_054368191.1 → XP_054224166.1  protein FAM168A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92567.2 GenPept UniProtKB/Swiss-Prot:Q92567

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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