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Vopp1 vesicular, overexpressed in cancer, prosurvival protein 1 [ Mus musculus (house mouse) ]

Gene ID: 232023, updated on 2-Nov-2024

Summary

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Official Symbol
Vopp1provided by MGI
Official Full Name
vesicular, overexpressed in cancer, prosurvival protein 1provided by MGI
Primary source
MGI:MGI:2141658
See related
Ensembl:ENSMUSG00000037788 AllianceGenome:MGI:2141658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ecop
Summary
Predicted to enable enzyme binding activity. Predicted to be located in cytoplasmic vesicle membrane; late endosome; and lysosome. Predicted to be active in organelle membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and neural retina. Orthologous to human VOPP1 (VOPP1 WW domain binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 31.4), CNS E14 (RPKM 28.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Vopp1 in Genome Data Viewer
Location:
6 B3; 6 27.82 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (57729249..57802110, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (57752264..57827983, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Pigy upstream reading frame Neighboring gene LanC (bacterial lantibiotic synthetase component C)-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E9272 Neighboring gene vomeronasal 1 receptor 21 Neighboring gene predicted gene, 25726

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in organelle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
WW domain binding protein VOPP1
Names
EGFR-coamplified and overexpressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411586.1 → NP_001398515.1  WW domain binding protein VOPP1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC127307

  2. NM_001411587.1 → NP_001398516.1  WW domain binding protein VOPP1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC127307, AC144816

  3. NM_001411588.1 → NP_001398517.1  WW domain binding protein VOPP1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC127307, AC144816

  4. NM_001411589.1 → NP_001398518.1  WW domain binding protein VOPP1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC127307, AC144816

  5. NM_001411590.1 → NP_001398519.1  WW domain binding protein VOPP1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC127307, AC144816

  6. NM_146168.1 → NP_666280.1  WW domain binding protein VOPP1 isoform a precursor

    See identical proteins and their annotated locations for NP_666280.1

    Status: VALIDATED

    Source sequence(s)
    BC024822
    Consensus CDS
    CCDS39497.1
    UniProtKB/Swiss-Prot
    Q3TZ79, Q8C0B7, Q8R1C3
    Related
    ENSMUSP00000109936.3, ENSMUST00000114297.5

RNA

  1. NR_177289.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127307, AC144816

  2. NR_177290.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127307, AC144816

  3. NR_177291.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127307, AC144816

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    57729249..57802110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1C3.1 GenPept UniProtKB/Swiss-Prot:Q8R1C3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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