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Fgd5 FYVE, RhoGEF and PH domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 232237, updated on 29-Oct-2024

Summary

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Official Symbol
Fgd5provided by MGI
Official Full Name
FYVE, RhoGEF and PH domain containing 5provided by MGI
Primary source
MGI:MGI:2443369
See related
Ensembl:ENSMUSG00000034037 AllianceGenome:MGI:2443369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFYVE23; mFLJ00274; C330025N11Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human FGD5 (FYVE, RhoGEF and PH domain containing 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in lung adult (RPKM 11.1), subcutaneous fat pad adult (RPKM 5.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fgd5 in Genome Data Viewer
Location:
6 D1; 6 41.0 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (91955809..92052986)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (91978827..92076005)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930590J08 gene Neighboring gene predicted gene, 53299 Neighboring gene STARR-positive B cell enhancer ABC_E539 Neighboring gene nuclear receptor subfamily 2, group C, member 2 Neighboring gene predicted gene, 46967 Neighboring gene mitochondrial ribosomal protein S25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation. Zhang T, et al. Dev Cell, 2024 Aug 19. PMID 38821057
  2. LncRNA FGD5-AS1 Promotes Abdominal Aortic Aneurysm Growth Through the Activation of MMP3 in Vascular Smooth Muscle Cells. Xu Z, et al. Int Heart J, 2023 May 31. PMID 37197924
  3. HSC-independent definitive hematopoiesis persists into adult life. Kobayashi M, et al. Cell Rep, 2023 Mar 28. PMID 36906851, Free PMC Article
  4. Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice. Cheng C, et al. Circulation, 2012 Jun 26. PMID 22661514
  5. Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. Konturek-Ciesla A, et al. Cell Rep, 2023 Apr 25. PMID 36961818

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
    Title: FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
  2. LncRNA FGD5-AS1 Promotes Abdominal Aortic Aneurysm Growth Through the Activation of MMP3 in Vascular Smooth Muscle Cells.
    Title: LncRNA FGD5-AS1 Promotes Abdominal Aortic Aneurysm Growth Through the Activation of MMP3 in Vascular Smooth Muscle Cells.
  3. Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
    Title: Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
  4. A new endothelial specific gene named FYVE, RhoGEF, and PH domain-containing 5 (FGD5) plays a crucial role in vascular pruning in a murine model.
    Title: Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00274

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FYVE, RhoGEF and PH domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172731.3 → NP_766319.3  FYVE, RhoGEF and PH domain-containing protein 5

    Status: VALIDATED

    Source sequence(s)
    AK086031, AW046885, BB612302, BC060664, CB246280, CN446877, CX568970
    Consensus CDS
    CCDS20371.2
    UniProtKB/TrEMBL
    E9QKY4, Q571N6
    Related
    ENSMUSP00000086748.3, ENSMUST00000089334.9
    Conserved Domains (5) summary
    cd13237
    Location:1418 → 1508
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    pfam00169
    Location:1167 → 1258
    PH; PH domain
    pfam00621
    Location:946 → 1134
    RhoGEF; RhoGEF domain
    cl17171
    Location:1152 → 1274
    PH-like; Pleckstrin homology-like domain
    cl22851
    Location:1288 → 1354
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    91955809..92052986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166057.1 → XP_036021950.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    Q571N6
    Conserved Domains (4) summary
    COG5271
    Location:95 → 407
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl28890
    Location:1289 → 1355
    FYVE_like_SF; FYVE domain like superfamily
    pfam00621
    Location:946 → 1134
    RhoGEF; RhoGEF domain
    cl17171
    Location:1153 → 1275
    PH-like; Pleckstrin homology-like domain

  2. XM_006506000.5 → XP_006506063.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    Q571N6
    Conserved Domains (5) summary
    cd13237
    Location:1419 → 1509
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    TIGR00927
    Location:95 → 339
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl28890
    Location:1289 → 1355
    FYVE_like_SF; FYVE domain like superfamily
    pfam00621
    Location:946 → 1134
    RhoGEF; RhoGEF domain
    cl17171
    Location:1153 → 1275
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UZ0.2 GenPept UniProtKB/Swiss-Prot:Q80UZ0

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