A2ml1 alpha-2-macroglobulin like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: A2ml1provided by MGI
Official Full Name: alpha-2-macroglobulin like 1provided by MGI
Primary source: MGI:MGI:3039594
See related: Ensembl:ENSMUSG00000047228 AllianceGenome:MGI:3039594
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ovos; Ovos2
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Part of protein-containing complex. Is expressed in several structures, including central nervous system; hemolymphoid system gland; smooth muscle tissue; stomach; and uterus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 19.2), liver E18 (RPKM 5.0) and 1 other tissue See more
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Genomic context

Location:: 6 F3; 6 63.05 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128516785..128577014, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128539822..128581606, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media.
Title: The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media.
A complex of novel protease inhibitor, ovostatin homolog, with its cognate proteases in immature mice uterine luminal fluid.
Title: A complex of novel protease inhibitor, ovostatin homolog, with its cognate proteases in immature mice uterine luminal fluid.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-2-macroglobulin-like protein 1

Names: ovostatin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001179.3 → NP_001001179.2 alpha-2-macroglobulin-like protein 1 precursor

See identical proteins and their annotated locations for NP_001001179.2

Status: VALIDATED

Source sequence(s)

AK138836, AK161068, AU044180

Consensus CDS

CCDS39651.1

UniProtKB/Swiss-Prot

E9QMV5, Q3UU35

Related

ENSMUSP00000059426.8, ENSMUST00000060574.9

Conserved Domains (6) summary

cd02897
Location:956 → 1253

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:736 → 826

A2M; Alpha-2-macroglobulin family

pfam01835
Location:121 → 204

A2M_N; MG2 domain

pfam07677
Location:1364 → 1447

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1008 → 1253

A2M_comp; A-macroglobulin complement component

pfam07703
Location:450 → 593

A2M_N_2; Alpha-2-macroglobulin family N-terminal region