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Tspan33 tetraspanin 33 [ Mus musculus (house mouse) ]

Gene ID: 232670, updated on 2-Nov-2024

Summary

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Official Symbol
Tspan33provided by MGI
Official Full Name
tetraspanin 33provided by MGI
Primary source
MGI:MGI:1919012
See related
Ensembl:ENSMUSG00000001763 AllianceGenome:MGI:1919012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pen; 1300010A20Rik
Summary
This gene encodes a member of the tetraspanin family which typically have four transmembrane domains. The encoded protein may be involved in the regulation of erythropoiesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Biased expression in liver E14.5 (RPKM 71.7), liver E14 (RPKM 63.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Tspan33 in Genome Data Viewer
Location:
6 A3.3; 6 12.36 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29694213..29718557)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29694214..29718558)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30896 Neighboring gene predicted gene, 38780 Neighboring gene smoothened, frizzled class receptor Neighboring gene predicted gene 13717 Neighboring gene STARR-positive B cell enhancer ABC_E677 Neighboring gene STARR-seq mESC enhancer starr_15451 Neighboring gene S-adenosylhomocysteine hydrolase-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29783505-29783805 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29787542-29787842 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29788430-29788731 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847059-29847242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847325-29847478

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling. Ruiz-García A, et al. J Immunol, 2016 Oct 15. PMID 27574297
  2. Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. Heikens MJ, et al. Blood, 2007 Apr 15. PMID 17158226
  3. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
  4. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Shah J, et al. Cell Rep, 2018 Nov 20. PMID 30463011
  5. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that TSPAN33 represents a new control element in the development of inflammation by macrophages that could constitute a potential therapeutic target.
    Title: The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling.
  2. Penumbra has a positive function in erythropoiesis and its deletion or mutation may result in anemia.
    Title: Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC30714

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in pore complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pore complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of pore complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of pore complex ISO
Inferred from Sequence Orthology
more info
  
located_in tetraspanin-enriched microdomain IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin-33
Names
penumbra
proerythroblast new membrane

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301407.1 → NP_001288336.1  tetraspanin-33 isoform 2

    See identical proteins and their annotated locations for NP_001288336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC069469, AK004954, BE949216, BF460925, BU054333, CJ068126
    Consensus CDS
    CCDS80506.1
    UniProtKB/Swiss-Prot
    Q8R3S2
    Related
    ENSMUSP00000110905.4, ENSMUST00000115250.4
    Conserved Domains (2) summary
    cd03158
    Location:115 → 235
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:22 → 263
    Tetraspannin; Tetraspanin family

  2. NM_146173.3 → NP_666285.1  tetraspanin-33 isoform 1

    See identical proteins and their annotated locations for NP_666285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC069469, AK004954, BE861472, BE949216, BF460925
    Consensus CDS
    CCDS19964.1
    UniProtKB/Swiss-Prot
    Q3TA03, Q8R3S2
    Related
    ENSMUSP00000045282.8, ENSMUST00000046750.14
    Conserved Domains (2) summary
    cd03158
    Location:116 → 236
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:22 → 264
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29694213..29718557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3S2.1 GenPept UniProtKB/Swiss-Prot:Q8R3S2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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