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Leng8 leukocyte receptor cluster (LRC) member 8 [ Mus musculus (house mouse) ]

Gene ID: 232798, updated on 2-Nov-2024

Summary

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Official Symbol
Leng8provided by MGI
Official Full Name
leukocyte receptor cluster (LRC) member 8provided by MGI
Primary source
MGI:MGI:2142195
See related
Ensembl:ENSMUSG00000035545 AllianceGenome:MGI:2142195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be active in nucleus. Is expressed in central nervous system; intestine; liver; lung; and retina. Orthologous to human LENG8 (leukocyte receptor cluster member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 180.8), thymus adult (RPKM 168.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Leng8 in Genome Data Viewer
Location:
7 A1; 7 2.39 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4140014..4151176)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4137013..4148177)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430041J12 gene Neighboring gene predicted gene, 23741 Neighboring gene STARR-seq mESC enhancer starr_17919 Neighboring gene RIKEN cDNA D030047H15 gene Neighboring gene tweety family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E8149 Neighboring gene STARR-seq mESC enhancer starr_17920 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster (LRC) member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
  2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leukocyte receptor cluster member 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374609.1 → NP_001361538.1  leukocyte receptor cluster member 8 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496
    Consensus CDS
    CCDS90150.1
    UniProtKB/TrEMBL
    D3YWS8
    Conserved Domains (2) summary
    PRK10263
    Location:113 → 362
    PRK10263; DNA translocase FtsK; Provisional
    cl24019
    Location:568 → 780
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  2. NM_001421713.1 → NP_001408642.1  leukocyte receptor cluster member 8 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  3. NM_001421715.1 → NP_001408644.1  leukocyte receptor cluster member 8 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  4. NM_001421716.1 → NP_001408645.1  leukocyte receptor cluster member 8 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  5. NM_001421717.1 → NP_001408646.1  leukocyte receptor cluster member 8 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  6. NM_001421718.1 → NP_001408647.1  leukocyte receptor cluster member 8 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496
    UniProtKB/TrEMBL
    D3YWS8
    Related
    ENSMUSP00000112428.2, ENSMUST00000121270.8

  7. NM_001421719.1 → NP_001408648.1  leukocyte receptor cluster member 8 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496
    UniProtKB/TrEMBL
    D3YWS8

  8. NM_001421720.1 → NP_001408649.1  leukocyte receptor cluster member 8 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  9. NM_001421721.1 → NP_001408650.1  leukocyte receptor cluster member 8 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496
    UniProtKB/Swiss-Prot
    Q3TCN4, Q8C3P0, Q8CBY3, Q8CGB8

  10. NM_001421722.1 → NP_001408651.1  leukocyte receptor cluster member 8 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496
    UniProtKB/Swiss-Prot
    Q3TCN4, Q8C3P0, Q8CBY3, Q8CGB8

  11. NM_001421723.1 → NP_001408652.1  leukocyte receptor cluster member 8 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  12. NM_001421724.1 → NP_001408653.1  leukocyte receptor cluster member 8 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  13. NM_001421725.1 → NP_001408654.1  leukocyte receptor cluster member 8 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  14. NM_001421726.1 → NP_001408655.1  leukocyte receptor cluster member 8 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496
    Related
    ENSMUST00000127723.8

  15. NM_001421727.1 → NP_001408656.1  leukocyte receptor cluster member 8 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  16. NM_001421728.1 → NP_001408657.1  leukocyte receptor cluster member 8 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496
    Related
    ENSMUSP00000113223.2, ENSMUST00000117274.8

  17. NM_001421729.1 → NP_001408658.1  leukocyte receptor cluster member 8 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

  18. NM_172736.4 → NP_766324.1  leukocyte receptor cluster member 8 homolog isoform 2

    See identical proteins and their annotated locations for NP_766324.1

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496
    Consensus CDS
    CCDS20731.1
    UniProtKB/Swiss-Prot
    Q3TCN4, Q8C3P0, Q8CBY3, Q8CGB8
    Related
    ENSMUSP00000046465.7, ENSMUST00000037472.13
    Conserved Domains (3) summary
    PRK10263
    Location:113 → 362
    PRK10263; DNA translocase FtsK; Provisional
    PRK14086
    Location:114 → 234
    dnaA; chromosomal replication initiator protein DnaA
    cl24019
    Location:568 → 749
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RNA

  1. NR_185324.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC101941, AC110496

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4140014..4151176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152936.1 → XP_036008829.1  leukocyte receptor cluster member 8 homolog isoform X4

    Conserved Domains (1) summary
    cl24019
    Location:548 → 762
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  2. XM_036152938.1 → XP_036008831.1  leukocyte receptor cluster member 8 homolog isoform X5

    Conserved Domains (1) summary
    cl24019
    Location:531 → 745
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  3. XM_036152935.1 → XP_036008828.1  leukocyte receptor cluster member 8 homolog isoform X4

    Conserved Domains (1) summary
    cl24019
    Location:548 → 762
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  4. XM_036152934.1 → XP_036008827.1  leukocyte receptor cluster member 8 homolog isoform X2

    Conserved Domains (2) summary
    PRK10263
    Location:113 → 399
    PRK10263; DNA translocase FtsK; Provisional
    cl24019
    Location:585 → 766
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBY3.1 GenPept UniProtKB/Swiss-Prot:Q8CBY3

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