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Kmt5c lysine methyltransferase 5C [ Mus musculus (house mouse) ]

Gene ID: 232811, updated on 2-Nov-2024

Summary

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Official Symbol
Kmt5cprovided by MGI
Official Full Name
lysine methyltransferase 5Cprovided by MGI
Primary source
MGI:MGI:2385262
See related
Ensembl:ENSMUSG00000059851 AllianceGenome:MGI:2385262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Suv420h2; Suv4-20h2
Summary
Enables histone H4K20 methyltransferase activity and histone binding activity. Involved in positive regulation of isotype switching. Located in condensed chromosome, centromeric region. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Orthologous to human KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 51.2), colon adult (RPKM 39.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Kmt5c in Genome Data Viewer
Location:
7 A1; 7 2.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4743091..4750513)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4740092..4747514)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E127 Neighboring gene predicted gene, 24537 Neighboring gene predicted gene, 42369 Neighboring gene STARR-seq mESC enhancer starr_17937 Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene golgi associated RAB2 interactor family member 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin. Hahn M, et al. Genes Dev, 2013 Apr 15. PMID 23599346, Free PMC Article
  2. Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing. Bierhoff H, et al. Mol Cell, 2014 May 22. PMID 24768537
  3. The histone methyltransferase SUV420H2 regulates brown and beige adipocyte thermogenesis. Cui X, et al. JCI Insight, 2024 May 7. PMID 38713533, Free PMC Article
  4. Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. Benetti R, et al. J Cell Biol, 2007 Sep 10. PMID 17846168, Free PMC Article
  5. H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells. Kurup JT, et al. Development, 2020 Dec 4. PMID 33144397, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The histone methyltransferase SUV420H2 regulates brown and beige adipocyte thermogenesis.
    Title: The histone methyltransferase SUV420H2 regulates brown and beige adipocyte thermogenesis.
  2. H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells.
    Title: H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells.
  3. KMT5c modulates adipocyte thermogenesis by regulating Trp53 expression.
    Title: KMT5c modulates adipocyte thermogenesis by regulating Trp53 expression.
  4. expression of Suv4-20h2 leads to sustained levels of H4K20me3, developmental arrest, and defects in S-phase progression.
    Title: SUV4-20 activity in the preimplantation mouse embryo controls timely replication.
  5. Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2.
    Title: lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.
  6. Results uncover a lncRNA-mediated mechanism that guides Suv4-20h2 to specific genomic loci to establish a more compact chromatin structure in growth-arrested cells.
    Title: Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.
  7. Data suggest that Suv4-20h1/Suv4-20h2 activity is required for fidelity of chromosome distribution during meiosis in oocyte; Suv4-20h1/Suv4-20h2 appear to control histone 4 methylation, centromere structure, and oocyte maturation/oogenesis.
    Title: Mouse oocyte meiosis is disturbed by knockdown of Suv4-20h.
  8. Suv4-20h2 is involved in the initial loading or maintenance of cohesion subunits
    Title: Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
  9. Abrogation of Suv4-20h enzymes and loss of heterochromatic mark H4K20me3 at telomeric heterochromatin facilitates telomere reprogramming and provides an increased tumorigenic potential to induced pluripotent stem cells.
    Title: Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells.
  10. SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation
    Title: Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC36471

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosyl-L-methionine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H4K20 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4K20 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K20 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K20 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K20me methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of isotype switching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase KMT5C
Names
[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B
[histone H4]-lysine20 N-methyltransferase KMT5B
histone-lysine N-methyltransferase SUV420H2
lysine-specific methyltransferase 5C
su(var)4-20 homolog 2
suppressor of variegation 4-20 homolog 2
NP_001108490.1
NP_001344973.1
NP_001407571.1
NP_001407572.1
NP_001407573.1
NP_001407574.1
NP_001407575.1
NP_001407576.1
NP_001407577.1
NP_001407578.1
NP_666289.2
XP_006539834.1
XP_006539835.1
XP_036008833.1
XP_036008834.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115018.2 → NP_001108490.1  histone-lysine N-methyltransferase KMT5C isoform 1

    See identical proteins and their annotated locations for NP_001108490.1

    Status: VALIDATED

    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20743.2
    UniProtKB/Swiss-Prot
    Q5RKP6, Q6Q783, Q8R1C5
    Related
    ENSMUSP00000096452.3, ENSMUST00000098853.9
    Conserved Domains (2) summary
    smart00317
    Location:120 → 224
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cl25800
    Location:245 → 366
    GGN; Gametogenetin

  2. NM_001358044.2 → NP_001344973.1  histone-lysine N-methyltransferase KMT5C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20743.2
    UniProtKB/Swiss-Prot
    Q5RKP6, Q6Q783, Q8R1C5
    Related
    ENSMUSP00000104223.4, ENSMUST00000108582.10
    Conserved Domains (2) summary
    smart00317
    Location:120 → 224
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cl25800
    Location:245 → 366
    GGN; Gametogenetin

  3. NM_001420642.1 → NP_001407571.1  histone-lysine N-methyltransferase KMT5C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161197

  4. NM_001420643.1 → NP_001407572.1  histone-lysine N-methyltransferase KMT5C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161197

  5. NM_001420644.1 → NP_001407573.1  histone-lysine N-methyltransferase KMT5C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161197

  6. NM_001420645.1 → NP_001407574.1  histone-lysine N-methyltransferase KMT5C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161197

  7. NM_001420646.1 → NP_001407575.1  histone-lysine N-methyltransferase KMT5C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC161197

  8. NM_001420647.1 → NP_001407576.1  histone-lysine N-methyltransferase KMT5C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC161197

  9. NM_001420648.1 → NP_001407577.1  histone-lysine N-methyltransferase KMT5C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC161197

  10. NM_001420649.1 → NP_001407578.1  histone-lysine N-methyltransferase KMT5C isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC161197

  11. NM_146177.3 → NP_666289.2  histone-lysine N-methyltransferase KMT5C isoform 1

    See identical proteins and their annotated locations for NP_666289.2

    Status: VALIDATED

    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20743.2
    UniProtKB/Swiss-Prot
    Q5RKP6, Q6Q783, Q8R1C5
    Related
    ENSMUSP00000104224.3, ENSMUST00000108583.9
    Conserved Domains (2) summary
    smart00317
    Location:120 → 224
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cl25800
    Location:245 → 366
    GGN; Gametogenetin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4743091..4750513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539772.1 → XP_006539835.1  histone-lysine N-methyltransferase KMT5C isoform X1

    See identical proteins and their annotated locations for XP_006539835.1

    Conserved Domains (2) summary
    PHA02682
    Location:281 → 346
    PHA02682; ORF080 virion core protein; Provisional
    cl40432
    Location:196 → 279
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  2. XM_036152941.1 → XP_036008834.1  histone-lysine N-methyltransferase KMT5C isoform X2

    Conserved Domains (2) summary
    PHA02682
    Location:276 → 397
    PHA02682; ORF080 virion core protein; Provisional
    cd19185
    Location:102 → 274
    SET_KMT5C; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins

  3. XM_006539771.5 → XP_006539834.1  histone-lysine N-methyltransferase KMT5C isoform X1

    See identical proteins and their annotated locations for XP_006539834.1

    Conserved Domains (2) summary
    PHA02682
    Location:281 → 346
    PHA02682; ORF080 virion core protein; Provisional
    cl40432
    Location:196 → 279
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  4. XM_036152940.1 → XP_036008833.1  histone-lysine N-methyltransferase KMT5C isoform X2

    Conserved Domains (2) summary
    PHA02682
    Location:276 → 397
    PHA02682; ORF080 virion core protein; Provisional
    cd19185
    Location:102 → 274
    SET_KMT5C; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Q783.1 GenPept UniProtKB/Swiss-Prot:Q6Q783

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