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DPY19L1 dpy-19 like C-mannosyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 23333, updated on 28-Oct-2024

Summary

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Official Symbol
DPY19L1provided by HGNC
Official Full Name
dpy-19 like C-mannosyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:22205
See related
Ensembl:ENSG00000173852 MIM:613892; AllianceGenome:HGNC:22205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Located in membrane. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis (RPKM 12.8), brain (RPKM 12.6) and 24 other tissues See more
Orthologs
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Genomic context

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See DPY19L1 in Genome Data Viewer
Location:
7p14.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (34928881..35038041, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (35069558..35178714, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (34968493..35077653, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NPSR1 antisense RNA 1 Neighboring gene neuropeptide S receptor 1 Neighboring gene RNA, 7SL, cytoplasmic 132, pseudogene Neighboring gene non-SMC condensin I complex subunit D2 pseudogene 1 Neighboring gene uncharacterized LOC102724723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18092 Neighboring gene microRNA 548n Neighboring gene ReSE screen-validated silencer GRCh37_chr7:35043370-35043968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:35067143-35067843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18094 Neighboring gene uncharacterized LOC105375228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:35096856-35097593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:35097594-35098330 Neighboring gene DPY19L2 pseudogene 1 Neighboring gene S100A11 pseudogene 2 Neighboring gene VISTA enhancer hs466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:35288961-35289528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:35289529-35290094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:35292632-35293208 Neighboring gene T-box transcription factor 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Shcherbakova A, et al. Proc Natl Acad Sci U S A, 2017 Mar 7. PMID 28202721, Free PMC Article
  2. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. Watanabe K, et al. Development, 2011 Nov. PMID 22028030, Free PMC Article
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Dec 31. PMID 10048485
  4. ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells. Bhushan J, et al. mBio, 2020 Oct 6. PMID 33024031, Free PMC Article
  5. Mitochondrial Raf1 Regulates Glutamine Catabolism. Shanderson RL, et al. bioRxiv, 2024 Mar 9. PMID 38496616, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with dpy-19-like 1 (DPY19L1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
protein C-mannosyl-transferase DPY19L1
Names
DPY-19-like protein 1
probable C-mannosyltransferase DPY19L1
protein dpy-19 homolog 1
NP_001353602.1
NP_056098.1
XP_011513548.1
XP_054213675.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366673.1 → NP_001353602.1  protein C-mannosyl-transferase DPY19L1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004711, AC004712, AC005271, AC005401
    Consensus CDS
    CCDS94084.1
    UniProtKB/TrEMBL
    A0A1B0GW05, A0A8I5KPK9
    Related
    ENSP00000490722.1, ENST00000638088.2
    Conserved Domains (1) summary
    pfam10034
    Location:102 → 744
    Dpy19; Q-cell neuroblast polarisation

  2. NM_015283.2 → NP_056098.1  protein C-mannosyl-transferase DPY19L1 isoform 2

    See identical proteins and their annotated locations for NP_056098.1

    Status: VALIDATED

    Source sequence(s)
    BC064476, DQ287932
    Consensus CDS
    CCDS43567.1
    UniProtKB/Swiss-Prot
    O94954, Q2PZI1, Q4G151
    UniProtKB/TrEMBL
    A0A8I5KPK9
    Related
    ENSP00000308695.4, ENST00000310974.8
    Conserved Domains (1) summary
    pfam10034
    Location:29 → 671
    Dpy19; Q-cell neuroblast polarization

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    34928881..35038041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515246.4 → XP_011513548.1  protein C-mannosyl-transferase DPY19L1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KPK9
    Conserved Domains (1) summary
    pfam10034
    Location:102 → 715
    Dpy19; Q-cell neuroblast polarization

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    35069558..35178714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357700.1 → XP_054213675.1  protein C-mannosyl-transferase DPY19L1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2PZI1.1 GenPept UniProtKB/Swiss-Prot:Q2PZI1

Gene LinkOut

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